RS11_MOUSE
ID RS11_MOUSE Reviewed; 158 AA.
AC P62281; P04643;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=40S ribosomal protein S11;
GN Name=Rps11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Rocha D., Anderson E., Botcherby M., Jordan B.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10580157; DOI=10.1016/s0378-1119(99)00429-1;
RA Higa S., Yoshihama M., Tanaka T., Kenmochi N.;
RT "Gene organization and sequence of the region containing the ribosomal
RT protein genes RPL13A and RPS11 in the human genome and conserved features
RT in the mouse genome.";
RL Gene 240:371-377(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-38; LYS-45 AND LYS-58, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-69, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [7]
RP CITRULLINATION AT ARG-22.
RX PubMed=24463520; DOI=10.1038/nature12942;
RA Christophorou M.A., Castelo-Branco G., Halley-Stott R.P., Oliveira C.S.,
RA Loos R., Radzisheuskaya A., Mowen K.A., Bertone P., Silva J.C.,
RA Zernicka-Goetz M., Nielsen M.L., Gurdon J.B., Kouzarides T.;
RT "Citrullination regulates pluripotency and histone H1 binding to
RT chromatin.";
RL Nature 507:104-108(2014).
CC -!- PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS17 family.
CC {ECO:0000305}.
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DR EMBL; U93864; AAB52256.1; -; mRNA.
DR EMBL; AB028894; BAA88216.1; -; Genomic_DNA.
DR EMBL; BC012641; AAH12641.1; -; mRNA.
DR CCDS; CCDS39947.1; -.
DR RefSeq; NP_038753.1; NM_013725.4.
DR PDB; 7CPU; EM; 2.82 A; SL=1-158.
DR PDB; 7CPV; EM; 3.03 A; SL=1-158.
DR PDB; 7LS1; EM; 3.30 A; w2=1-158.
DR PDB; 7LS2; EM; 3.10 A; w2=1-158.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P62281; -.
DR SMR; P62281; -.
DR BioGRID; 205129; 93.
DR ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR DIP; DIP-59975N; -.
DR IntAct; P62281; 2.
DR MINT; P62281; -.
DR STRING; 10090.ENSMUSP00000003521; -.
DR iPTMnet; P62281; -.
DR PhosphoSitePlus; P62281; -.
DR SwissPalm; P62281; -.
DR EPD; P62281; -.
DR jPOST; P62281; -.
DR PaxDb; P62281; -.
DR PeptideAtlas; P62281; -.
DR PRIDE; P62281; -.
DR ProteomicsDB; 262710; -.
DR Antibodypedia; 32033; 205 antibodies from 26 providers.
DR DNASU; 27207; -.
DR Ensembl; ENSMUST00000003521; ENSMUSP00000003521; ENSMUSG00000003429.
DR GeneID; 27207; -.
DR KEGG; mmu:27207; -.
DR UCSC; uc009gth.2; mouse.
DR CTD; 6205; -.
DR MGI; MGI:1351329; Rps11.
DR VEuPathDB; HostDB:ENSMUSG00000003429; -.
DR eggNOG; KOG1728; Eukaryota.
DR GeneTree; ENSGT00390000002732; -.
DR HOGENOM; CLU_073626_0_2_1; -.
DR InParanoid; P62281; -.
DR OMA; KKYERYE; -.
DR OrthoDB; 1325168at2759; -.
DR PhylomeDB; P62281; -.
DR TreeFam; TF300126; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72649; Translation initiation complex formation.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 27207; 31 hits in 65 CRISPR screens.
DR ChiTaRS; Rps11; mouse.
DR PRO; PR:P62281; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P62281; protein.
DR Bgee; ENSMUSG00000003429; Expressed in epiblast (generic) and 70 other tissues.
DR ExpressionAtlas; P62281; baseline and differential.
DR Genevisible; P62281; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR032440; Ribosomal_S11_N.
DR InterPro; IPR000266; Ribosomal_S17/S11.
DR InterPro; IPR028333; Ribosomal_S17_arc-typ.
DR InterPro; IPR019979; Ribosomal_S17_CS.
DR PANTHER; PTHR10744; PTHR10744; 1.
DR Pfam; PF00366; Ribosomal_S17; 1.
DR Pfam; PF16205; Ribosomal_S17_N; 1.
DR PRINTS; PR00973; RIBOSOMALS17.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR03630; uS17_arch; 1.
DR PROSITE; PS00056; RIBOSOMAL_S17; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Citrullination; Lipoprotein; Methylation;
KW Palmitate; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62280"
FT CHAIN 2..158
FT /note="40S ribosomal protein S11"
FT /id="PRO_0000128511"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P62280"
FT MOD_RES 22
FT /note="Citrulline"
FT /evidence="ECO:0000269|PubMed:24463520"
FT MOD_RES 38
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 45
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 58
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62280"
FT MOD_RES 69
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62280"
FT LIPID 60
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 158 AA; 18431 MW; 9FB75DC1D99614B0 CRC64;
MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA IEGTYIDKKC
PFTGNVSIRG RILSGVVTKM KMQRTIVIRR DYLHYIRKYN RFEKRHKNMS VHLSPCFRDV
QIGDIVTVGE CRPLSKTVRF NVLKVTKAAG TKKQFQKF
