RS12_PLAF7
ID RS12_PLAF7 Reviewed; 141 AA.
AC O97249;
DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=40S ribosomal protein S12;
GN Name=RPS12; ORFNames=MAL3P2.28, PFC0295C;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS12 family.
CC {ECO:0000305}.
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DR EMBL; AL844502; CAB39015.1; -; Genomic_DNA.
DR RefSeq; XP_001351146.1; XM_001351110.1.
DR PDB; 3J7A; EM; 3.20 A; R=1-141.
DR PDB; 3JBN; EM; 4.70 A; R=22-135.
DR PDB; 3JBO; EM; 5.80 A; R=22-135.
DR PDB; 3JBP; EM; 6.70 A; R=22-135.
DR PDB; 6OKK; EM; 3.30 A; R=1-141.
DR PDBsum; 3J7A; -.
DR PDBsum; 3JBN; -.
DR PDBsum; 3JBO; -.
DR PDBsum; 3JBP; -.
DR PDBsum; 6OKK; -.
DR AlphaFoldDB; O97249; -.
DR SMR; O97249; -.
DR IntAct; O97249; 1.
DR STRING; 5833.PFC0295c; -.
DR PRIDE; O97249; -.
DR EnsemblProtists; CAB39015; CAB39015; PF3D7_0307100.
DR GeneID; 814388; -.
DR KEGG; pfa:PF3D7_0307100; -.
DR VEuPathDB; PlasmoDB:PF3D7_0307100; -.
DR HOGENOM; CLU_110343_1_0_1; -.
DR InParanoid; O97249; -.
DR OMA; CDEPMYK; -.
DR PhylomeDB; O97249; -.
DR Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-PFA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-PFA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-PFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-PFA-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-PFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000001450; Chromosome 3.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:GeneDB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:GeneDB.
DR GO; GO:0006412; P:translation; ISS:GeneDB.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR000530; Ribosomal_S12e.
DR PANTHER; PTHR11843; PTHR11843; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00972; RIBSOMALS12E.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01189; RIBOSOMAL_S12E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..141
FT /note="40S ribosomal protein S12"
FT /id="PRO_0000122331"
FT HELIX 23..35
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 43..49
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 50..52
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 67..77
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 91..96
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 129..134
FT /evidence="ECO:0007829|PDB:3J7A"
SQ SEQUENCE 141 AA; 15396 MW; C8EDC1608B388659 CRC64;
MSDVESADNN VVVEEKAVFD NVTAIQKVIK NAHVHDGLKI GIREVIKSIE SQEAKVCFLS
DVCSEPAYKK LITTLCAEKN IPLFMVQNDS KDLGHWAGLF KLDNEGNARK IIGASSVAVV
DFGEDSAEKD FLLSQNQTVT A
