RS12_RAT
ID RS12_RAT Reviewed; 132 AA.
AC P63324; P09388; P12728;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=40S ribosomal protein S12;
GN Name=Rps12;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-132, AND ACETYLATION AT
RP ALA-2.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=3308890; DOI=10.1016/s0021-9258(18)47944-6;
RA Lin A., Chan Y.-L., Jones R., Wool I.G.;
RT "The primary structure of rat ribosomal protein S12. The relationship of
RT rat S12 to other ribosomal proteins and a correlation of the amino acid
RT sequences of rat and yeast ribosomal proteins.";
RL J. Biol. Chem. 262:14343-14351(1987).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=2207170; DOI=10.1016/0167-4781(90)90143-p;
RA Wool I.G., Chan Y.-L., Paz V., Olvera J.;
RT "The primary structure of rat ribosomal proteins: the amino acid sequences
RT of L27a and L28 and corrections in the sequences of S4 and S12.";
RL Biochim. Biophys. Acta 1050:69-73(1990).
RN [3]
RP PROTEIN SEQUENCE OF 2-33, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Pheochromocytoma;
RA Bienvenut W.V., von Kriegsheim A.F., Kolch W.;
RL Submitted (AUG-2006) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS12 family.
CC {ECO:0000305}.
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DR EMBL; M18547; AAA42077.1; ALT_TERM; mRNA.
DR PIR; S13074; R3RT12.
DR AlphaFoldDB; P63324; -.
DR SMR; P63324; -.
DR IntAct; P63324; 3.
DR STRING; 10116.ENSRNOP00000022184; -.
DR iPTMnet; P63324; -.
DR PhosphoSitePlus; P63324; -.
DR SwissPalm; P63324; -.
DR jPOST; P63324; -.
DR PaxDb; P63324; -.
DR PRIDE; P63324; -.
DR RGD; 62024; Rps12.
DR eggNOG; KOG3406; Eukaryota.
DR InParanoid; P63324; -.
DR PhylomeDB; P63324; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P63324; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR000530; Ribosomal_S12e.
DR PANTHER; PTHR11843; PTHR11843; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00972; RIBSOMALS12E.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01189; RIBOSOMAL_S12E; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:3308890, ECO:0000269|Ref.3"
FT CHAIN 2..132
FT /note="40S ribosomal protein S12"
FT /id="PRO_0000122326"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:3308890, ECO:0000269|Ref.3"
FT MOD_RES 129
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63323"
SQ SEQUENCE 132 AA; 14525 MW; 4C3D1BED455FFA2A CRC64;
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM
YVKLVEALLA EHQINLIKVD DNKKLGEWVG LCKIDREGKP RKVVGCSCVV VKDYGKESQA
KDVIEEYFKC KK
