ABAA_GIBZE
ID ABAA_GIBZE Reviewed; 858 AA.
AC I1S4T3; A0A098D398; A0A098D4N6; A0A0E0RNT6; A0A1C3YIE9; A0A1I9EWX2; I1S4T2;
AC S5FRT9;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 3.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Conidiophore development regulator abaA {ECO:0000305};
GN Name=abaA {ECO:0000303|PubMed:24039821};
GN ORFNames=FGRAMPH1_01T02219, FGRRES_15794/FGRRES_11850,
GN FGSG_11851/FGSG_11850;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 76-858, FUNCTION, DISRUPTION PHENOTYPE, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=24039821; DOI=10.1371/journal.pone.0072915;
RA Son H., Kim M.G., Min K., Seo Y.S., Lim J.Y., Choi G.J., Kim J.C.,
RA Chae S.K., Lee Y.W.;
RT "AbaA regulates conidiogenesis in the ascomycete fungus Fusarium
RT graminearum.";
RL PLoS ONE 8:E72915-E72915(2013).
RN [5]
RP INDUCTION.
RX PubMed=25277408; DOI=10.1007/s12275-014-4384-6;
RA Son H., Kim M.G., Chae S.K., Lee Y.W.;
RT "FgFlbD regulates hyphal differentiation required for sexual and asexual
RT reproduction in the ascomycete fungus Fusarium graminearum.";
RL J. Microbiol. 52:930-939(2014).
CC -!- FUNCTION: AbaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation (By similarity). They act
CC individually and together to regulate their own expression and that of
CC numerous other sporulation-specific genes (By similarity). Binds to the
CC sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and
CC minor-groove contacts (By similarity). Plays a pivotal role in
CC conidiation by regulating cell cycle pathways and other conidiation-
CC related genes (PubMed:24039821). {ECO:0000250|UniProtKB:P20945,
CC ECO:0000269|PubMed:24039821}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24039821}.
CC Note=localizes to the nuclei of phialides and terminal cells of mature
CC conidia (PubMed:24039821). {ECO:0000269|PubMed:24039821}.
CC -!- INDUCTION: Expression is positively regulated by flbD
CC (PubMed:25277408). {ECO:0000269|PubMed:25277408}.
CC -!- DISRUPTION PHENOTYPE: Leads to abnormally shaped phialides and
CC abolishes production of conidia (PubMed:24039821).
CC {ECO:0000269|PubMed:24039821}.
CC -!- SIMILARITY: Belongs to the TEC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AGQ43489.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=ESU06130.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ESU06131.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=SCB64136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DS231663; ESU06130.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DS231663; ESU06131.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970332; SCB64136.1; ALT_INIT; Genomic_DNA.
DR EMBL; KC825340; AGQ43489.1; ALT_FRAME; mRNA.
DR RefSeq; XP_011316615.1; XM_011318313.1.
DR RefSeq; XP_011316616.1; XM_011318314.1.
DR AlphaFoldDB; I1S4T3; -.
DR SMR; I1S4T3; -.
DR STRING; 5518.FGSG_11850P0; -.
DR EnsemblFungi; ESU06130; ESU06130; FGSG_11850.
DR EnsemblFungi; ESU06131; ESU06131; FGSG_11851.
DR GeneID; 23558669; -.
DR GeneID; 23558670; -.
DR KEGG; fgr:FGSG_11850; -.
DR KEGG; fgr:FGSG_11851; -.
DR eggNOG; KOG0110; Eukaryota.
DR HOGENOM; CLU_2164355_0_0_1; -.
DR PHI-base; PHI:3828; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 6.10.20.40; -; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR Pfam; PF01285; TEA; 1.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; Nucleus; Reference proteome; Sporulation;
KW Transcription; Transcription regulation.
FT CHAIN 1..858
FT /note="Conidiophore development regulator abaA"
FT /id="PRO_0000435936"
FT DNA_BIND 128..221
FT /note="TEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 514..521
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 219
FT /note="E -> K (in Ref. 4; AGQ43489)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 858 AA; 96444 MW; 70A8340BEA006F4C CRC64;
MSSSLYHPRP VLSSQRYTPS PDYLQDARRT YHDNSRLPLR ETASNAQSHN FNSMVPCYSS
QVGISPSVPA SLPAPMIPSQ SFECLYRVPT PRNQPRFQQR RPRNEVNPLY FWPAFRQYRN
RQAHKDTQKD KGGVWRRPEL EDAFVDSVLL MPHMGRRKFS MGGKLHGRNM LISEYIFTIC
VAILGSKEIF RIDNSNDSIE QMGRKQVSSH MQVVKKFFED LRCFHFLFPA EEKKEPGSTN
SDDYYDEEEQ ESFKSNPVLT ALAEGRVPDV KPNYEYFSQL LALQSLISVR PKTAEVYVSS
SEVKFRDEIA YDAQDAPLDT ESFPHLNKYN NCDDSPSVLG KDVLLHEYTR SLDRTTSACV
KTVTRRWQKD APEIYETLEL PTRDEECLLL EMCATLELHE HARFPSGSEL TGFVEVAITN
PNLQSHRWKC VTRLTRPSEL HSDDKKSSVY TNETGIHRRG CSDSKPDCDC HSRPRQDIHV
PFPAVEWASI LSMAVQYPDV EHQRKKEKRT KGDDRKNLDR AGSKRKRSED DGDAASWARR
DLTGSDLICK VAMYQELWSC APDSNRWVRQ GIVFWRFNTT NQWYKYNPVF KPAGTSWRWL
TVNDPMSRYH QQKALVYPSA SMSLDSIMSP TPSINQHMTA AMNETFSSAW DPSVSLAQVP
NATATNNGLT LFESFSGGLA TPPPTAGLQG SYSGSFDHGM PPSTGVGFIP STCSTAGESH
PGTGHGHSHS AAYYDAQTTL ADLKPVMSTV NPYQSPTTSS GLDLSSSLVY DNAECDTGLQ
GWDMPALDGW STGAGSGSEW GSHHKVEPSS DQTALWTQSQ WAQMAGDRDG SPRPMKRRRG
DGIDSHIPPT MTAAAGGW
