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ABAA_METRA
ID   ABAA_METRA              Reviewed;         885 AA.
AC   E9EMI7;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   04-MAR-2015, sequence version 2.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Conidiophore development regulator abaA {ECO:0000303|PubMed:29958281};
GN   Name=AbaA {ECO:0000303|PubMed:29958281}; ORFNames=MAA_00694;
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075;
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075;
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
RN   [3]
RP   IDENTIFICATION, DISRUPTION PHENOTYPE, FUNCTION, AND INDUCTION.
RX   PubMed=29958281; DOI=10.1371/journal.pgen.1007472;
RA   Zeng G., Zhang P., Zhang Q., Zhao H., Li Z., Zhang X., Wang C., Yin W.B.,
RA   Fang W.;
RT   "Duplication of a Pks gene cluster and subsequent functional
RT   diversification facilitate environmental adaptation in Metarhizium
RT   species.";
RL   PLoS Genet. 14:E1007472-E1007472(2018).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation. They act individually and together
CC       to regulate their own expression and that of numerous other
CC       sporulation-specific genes (PubMed:29958281). BrlA, abaA and wetA act
CC       together to positively regulate the expression of the Pks1 gene cluster
CC       that mediates the biosynthesis of an anthraquinone derivative pigment
CC       that contributes to conidial pigmentation that provides protection from
CC       UV radiation, heat and cold stress (PubMed:29958281).
CC       {ECO:0000269|PubMed:29958281}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression increases significantly during initiation of
CC       conidiation and remains elevated until colourisation is stabilized
CC       (PubMed:29958281). Expression is positively regulated by BrlA
CC       (PubMed:29958281). {ECO:0000269|PubMed:29958281}.
CC   -!- DISRUPTION PHENOTYPE: Produces phialides on which short deformed hypha
CC       are formed. {ECO:0000269|PubMed:29958281}.
CC   -!- SIMILARITY: Belongs to the TEC1 family. {ECO:0000305}.
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DR   EMBL; ADNJ02000007; EFZ03620.2; -; Genomic_DNA.
DR   RefSeq; XP_007816883.2; XM_007818692.2.
DR   AlphaFoldDB; E9EMI7; -.
DR   EnsemblFungi; EFZ03620; EFZ03620; MAA_00694.
DR   GeneID; 19254980; -.
DR   KEGG; maj:MAA_00694; -.
DR   HOGENOM; CLU_009126_0_0_1; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.20.40; -; 1.
DR   InterPro; IPR000818; TEA/ATTS_dom.
DR   InterPro; IPR038096; TEA/ATTS_sf.
DR   Pfam; PF01285; TEA; 1.
DR   SMART; SM00426; TEA; 1.
DR   PROSITE; PS51088; TEA_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; Nucleus; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..885
FT                   /note="Conidiophore development regulator abaA"
FT                   /id="PRO_0000445756"
FT   DNA_BIND        124..217
FT                   /note="TEA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          817..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        502..536
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..877
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  99498 MW;  B9DEE47C6902B4B0 CRC64;
     MSSLFQPRPV LSSQRYSQSP DYVDTRRSIH NGRLPLREST GNAQSHSFNG LVSCYQNQVA
     LAPSMQTTIP APMVPSQSLD CLYRVPTPRQ QARFQRRPKT SVNPLYFWPA FRQYRNRQAH
     KDTQKDKGGV WRRPELEDAF VDSVLLMPHM GRRKFSMGGK LHGRNMLISE YIFVICIALL
     GSKEIFRIDN SNESIEQMGR KQVSSHMQVV KKFFEDLRCF HFLFPSEEKK EPGSTNSDDC
     YDEEEQESFK SNPVLTALAE GRVPDVKPNY EYFSQLLALQ SSICTRPKTC EIFVSSSDIK
     IRDDVAYDVH DTPLDQASFP HLNKYTNCDD SPNVLGKDVL LHEYTRSLDR TTSACAKSVT
     RRWQHDAPAM YETLELPSRD EECLLLEMCA TLELHEHAKF PSGSELTGFV EVAITQPALQ
     NHRWKCITRL TRPAELHSDE GKHGVYTNDS GIHRRGCSDS KAECECHTRP RQDIHVPFPA
     VEWASILSMA VQYPDVEHQR LKEKRRKYAD GDGKKELERA GSKRKRSEDE GDAASWTRRE
     PTGSDLICKV AMYQELWSCA PDSTQWTRQA IIFWRFNTTN QWHKYNPVFK PAGTTWRWLT
     INDPMSRYHQ QKALVYPTAN VSRDALMSPT PTIHQHLTAA MNETFNSWDQ GSSAPHVPHV
     PPLQTPNNSI GLFDSFSNGL ATPPPTATLP PAYPTGNFDS RSGSFDARSA SFDTRSGSFD
     GNLGPNNGVA FLPTTGPPPQ HERQPTALGN NNQPFFDGQQ SFSEVKPINT AVNSYMTAST
     SLELPNQLVY DNSGVDTSNM QGWDMSALDG WSAAASAPGS ATAEWGPNTK VESHAGDHHG
     AMWAPPHWPL SAGAAPSSHE RGASPRPLKR RRETMDVHVP VTAGW
 
 
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