ABAA_METRA
ID ABAA_METRA Reviewed; 885 AA.
AC E9EMI7;
DT 05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 2.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Conidiophore development regulator abaA {ECO:0000303|PubMed:29958281};
GN Name=AbaA {ECO:0000303|PubMed:29958281}; ORFNames=MAA_00694;
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075;
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075;
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
RN [3]
RP IDENTIFICATION, DISRUPTION PHENOTYPE, FUNCTION, AND INDUCTION.
RX PubMed=29958281; DOI=10.1371/journal.pgen.1007472;
RA Zeng G., Zhang P., Zhang Q., Zhao H., Li Z., Zhang X., Wang C., Yin W.B.,
RA Fang W.;
RT "Duplication of a Pks gene cluster and subsequent functional
RT diversification facilitate environmental adaptation in Metarhizium
RT species.";
RL PLoS Genet. 14:E1007472-E1007472(2018).
CC -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation. They act individually and together
CC to regulate their own expression and that of numerous other
CC sporulation-specific genes (PubMed:29958281). BrlA, abaA and wetA act
CC together to positively regulate the expression of the Pks1 gene cluster
CC that mediates the biosynthesis of an anthraquinone derivative pigment
CC that contributes to conidial pigmentation that provides protection from
CC UV radiation, heat and cold stress (PubMed:29958281).
CC {ECO:0000269|PubMed:29958281}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression increases significantly during initiation of
CC conidiation and remains elevated until colourisation is stabilized
CC (PubMed:29958281). Expression is positively regulated by BrlA
CC (PubMed:29958281). {ECO:0000269|PubMed:29958281}.
CC -!- DISRUPTION PHENOTYPE: Produces phialides on which short deformed hypha
CC are formed. {ECO:0000269|PubMed:29958281}.
CC -!- SIMILARITY: Belongs to the TEC1 family. {ECO:0000305}.
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DR EMBL; ADNJ02000007; EFZ03620.2; -; Genomic_DNA.
DR RefSeq; XP_007816883.2; XM_007818692.2.
DR AlphaFoldDB; E9EMI7; -.
DR EnsemblFungi; EFZ03620; EFZ03620; MAA_00694.
DR GeneID; 19254980; -.
DR KEGG; maj:MAA_00694; -.
DR HOGENOM; CLU_009126_0_0_1; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 6.10.20.40; -; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR Pfam; PF01285; TEA; 1.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; Nucleus; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..885
FT /note="Conidiophore development regulator abaA"
FT /id="PRO_0000445756"
FT DNA_BIND 124..217
FT /note="TEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 99498 MW; B9DEE47C6902B4B0 CRC64;
MSSLFQPRPV LSSQRYSQSP DYVDTRRSIH NGRLPLREST GNAQSHSFNG LVSCYQNQVA
LAPSMQTTIP APMVPSQSLD CLYRVPTPRQ QARFQRRPKT SVNPLYFWPA FRQYRNRQAH
KDTQKDKGGV WRRPELEDAF VDSVLLMPHM GRRKFSMGGK LHGRNMLISE YIFVICIALL
GSKEIFRIDN SNESIEQMGR KQVSSHMQVV KKFFEDLRCF HFLFPSEEKK EPGSTNSDDC
YDEEEQESFK SNPVLTALAE GRVPDVKPNY EYFSQLLALQ SSICTRPKTC EIFVSSSDIK
IRDDVAYDVH DTPLDQASFP HLNKYTNCDD SPNVLGKDVL LHEYTRSLDR TTSACAKSVT
RRWQHDAPAM YETLELPSRD EECLLLEMCA TLELHEHAKF PSGSELTGFV EVAITQPALQ
NHRWKCITRL TRPAELHSDE GKHGVYTNDS GIHRRGCSDS KAECECHTRP RQDIHVPFPA
VEWASILSMA VQYPDVEHQR LKEKRRKYAD GDGKKELERA GSKRKRSEDE GDAASWTRRE
PTGSDLICKV AMYQELWSCA PDSTQWTRQA IIFWRFNTTN QWHKYNPVFK PAGTTWRWLT
INDPMSRYHQ QKALVYPTAN VSRDALMSPT PTIHQHLTAA MNETFNSWDQ GSSAPHVPHV
PPLQTPNNSI GLFDSFSNGL ATPPPTATLP PAYPTGNFDS RSGSFDARSA SFDTRSGSFD
GNLGPNNGVA FLPTTGPPPQ HERQPTALGN NNQPFFDGQQ SFSEVKPINT AVNSYMTAST
SLELPNQLVY DNSGVDTSNM QGWDMSALDG WSAAASAPGS ATAEWGPNTK VESHAGDHHG
AMWAPPHWPL SAGAAPSSHE RGASPRPLKR RRETMDVHVP VTAGW