RS13_DROME
ID RS13_DROME Reviewed; 151 AA.
AC Q03334; A4V0F6; Q9VLN5;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=40S ribosomal protein S13;
GN Name=RpS13; Synonyms=M(2)32A, Rp17; ORFNames=CG13389;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Head;
RX PubMed=8506150; DOI=10.1093/nar/21.10.2523;
RA McNabb S., Ashburner M.;
RT "Identification of a Drosophila protein similar to rat S13 and
RT archaebacterial S11 ribosomal proteins.";
RL Nucleic Acids Res. 21:2523-2523(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Canton-S; TISSUE=Larva;
RX PubMed=8725235; DOI=10.1093/genetics/143.2.877;
RA Saeboe-Larssen S., Lambertsson A.;
RT "A novel Drosophila Minute locus encodes ribosomal protein S13.";
RL Genetics 143:877-885(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS15 family.
CC {ECO:0000305}.
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DR EMBL; Z19052; CAA79496.1; -; mRNA.
DR EMBL; X91853; CAA62964.1; -; Genomic_DNA.
DR EMBL; X91854; CAA62965.1; -; mRNA.
DR EMBL; AE014134; AAF52649.1; -; Genomic_DNA.
DR EMBL; AE014134; ABC65883.1; -; Genomic_DNA.
DR EMBL; AY058536; AAL13765.1; -; mRNA.
DR PIR; S70391; S33684.
DR RefSeq; NP_001033885.1; NM_001038796.3.
DR RefSeq; NP_001285747.1; NM_001298818.1.
DR RefSeq; NP_476938.1; NM_057590.5.
DR PDB; 4V6W; EM; 6.00 A; AN=1-151.
DR PDB; 6XU6; EM; 3.50 A; AN=2-151.
DR PDB; 6XU7; EM; 4.90 A; AN=2-151.
DR PDB; 6XU8; EM; 3.00 A; AN=2-151.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; Q03334; -.
DR SMR; Q03334; -.
DR BioGRID; 60275; 112.
DR DIP; DIP-17858N; -.
DR IntAct; Q03334; 2.
DR STRING; 7227.FBpp0079328; -.
DR PaxDb; Q03334; -.
DR PRIDE; Q03334; -.
DR DNASU; 34149; -.
DR EnsemblMetazoa; FBtr0079724; FBpp0079328; FBgn0010265.
DR EnsemblMetazoa; FBtr0100541; FBpp0099990; FBgn0010265.
DR EnsemblMetazoa; FBtr0346454; FBpp0312104; FBgn0010265.
DR GeneID; 34149; -.
DR KEGG; dme:Dmel_CG13389; -.
DR CTD; 6207; -.
DR FlyBase; FBgn0010265; RpS13.
DR VEuPathDB; VectorBase:FBgn0010265; -.
DR eggNOG; KOG0400; Eukaryota.
DR HOGENOM; CLU_090139_1_0_1; -.
DR InParanoid; Q03334; -.
DR OMA; EEHPKDM; -.
DR OrthoDB; 1387147at2759; -.
DR PhylomeDB; Q03334; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DME-72649; Translation initiation complex formation.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DME-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q03334; -.
DR BioGRID-ORCS; 34149; 0 hits in 1 CRISPR screen.
DR ChiTaRS; RpS13; fly.
DR GenomeRNAi; 34149; -.
DR PRO; PR:Q03334; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0010265; Expressed in adult Malpighian tubule (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q03334; baseline and differential.
DR Genevisible; Q03334; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:FlyBase.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR CDD; cd00353; Ribosomal_S15p_S13e; 1.
DR HAMAP; MF_01343_A; Ribosomal_S15_A; 1.
DR InterPro; IPR012606; Ribosomal_S13/S15_N.
DR InterPro; IPR000589; Ribosomal_S15.
DR InterPro; IPR023029; Ribosomal_S15P.
DR InterPro; IPR009068; S15_NS1_RNA-bd.
DR PANTHER; PTHR11885; PTHR11885; 1.
DR Pfam; PF08069; Ribosomal_S13_N; 1.
DR Pfam; PF00312; Ribosomal_S15; 1.
DR SMART; SM01386; Ribosomal_S13_N; 1.
DR SMART; SM01387; Ribosomal_S15; 1.
DR SUPFAM; SSF47060; SSF47060; 1.
DR PROSITE; PS00362; RIBOSOMAL_S15; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..151
FT /note="40S ribosomal protein S13"
FT /id="PRO_0000115676"
FT CONFLICT 40..49
FT /note="LGKKGLTPSK -> AGQEGSDSLQ (in Ref. 1; CAA79496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 151 AA; 17178 MW; 498306F4F14B76F8 CRC64;
MGRMHAPGKG ISQSALPYRR TVPSWLKLNA DDVKEQIKKL GKKGLTPSKI GIILRDSHGV
AQVRFVNGNK ILRIMKSVGL KPDIPEDLYH MIKKAVAIRK HLERNRKDKD GKFRLILVES
RIHRLARYYK TKSVLPPNWK YESSTASALV A
