ID   ABAE_APIME              Reviewed;          53 AA.
AC   P15450;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Abaecin;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7961803; DOI=10.1016/s0021-9258(19)61943-5;
RA   Casteels-Josson K., Zhang W., Capaci T., Casteels P., Tempst P.;
RT   "Acute transcriptional response of the honeybee peptide-antibiotics gene
RT   repertoire and required post-translational conversion of the precursor
RT   structures.";
RL   J. Biol. Chem. 269:28569-28575(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-53.
RC   TISSUE=Hemolymph;
RX   PubMed=2298215; DOI=10.1111/j.1432-1033.1990.tb15315.x;
RA   Casteels P., Ampe C., Riviere L., van Damme J., Elicone C., Jacobs F.,
RA   Tempst P.;
RT   "Isolation and characterization of abaecin, a major antibacterial response
RT   peptide in the honeybee (Apis mellifera).";
RL   Eur. J. Biochem. 187:381-386(1990).
CC   -!- FUNCTION: This peptide has bactericidal activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; U15954; AAA67442.1; -; mRNA.
DR   PIR; B55392; B55392.
DR   RefSeq; NP_001011617.1; NM_001011617.1.
DR   AlphaFoldDB; P15450; -.
DR   STRING; 7460.GB47318-PA; -.
DR   TCDB; 1.C.116.1.1; the membrane-permeabilizing peptide, abaecin (abaecin) family.
DR   PaxDb; P15450; -.
DR   EnsemblMetazoa; NM_001011617; NP_001011617; LOC406144.
DR   GeneID; 406144; -.
DR   KEGG; ame:406144; -.
DR   HOGENOM; CLU_3089147_0_0_1; -.
DR   InParanoid; P15450; -.
DR   OMA; WKPFPTF; -.
DR   OrthoDB; 583722at2759; -.
DR   PhylomeDB; P15450; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0042381; P:hemolymph coagulation; IEA:InterPro.
DR   InterPro; IPR012524; Abaecin_antimicrobial_peptide.
DR   Pfam; PF08026; Antimicrobial_5; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:2298215"
FT   CHAIN           20..53
FT                   /note="Abaecin"
FT                   /id="PRO_0000004946"
FT   VARIANT         52
FT                   /note="G -> S"
SQ   SEQUENCE   53 AA;  5903 MW;  0EB1F0CC57797FBC CRC64;
     MKVVIFIFAL LATICAAFAY VPLPNVPQPG RRPFPTFPGQ GPFNPKIKWP QGY