ID   AZR1_SCHPO              Reviewed;         299 AA.
AC   Q09189; Q9UTJ6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=5-azacytidine resistance protein azr1;
GN   Name=azr1; ORFNames=SPAC1556.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9153756;
RX   DOI=10.1002/(sici)1097-0061(199704)13:5<463::aid-yea89>3.0.co;2-b;
RA   Platt G.M., Price C.;
RT   "Isolation of a Schizosaccharomyces pombe gene which in high copy confers
RT   resistance to the nucleoside analogue 5-azacytidine.";
RL   Yeast 13:463-474(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Confers azacytidine resistance in high copy.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA66973.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X98329; CAA66973.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CU329670; CAB61214.2; -; Genomic_DNA.
DR   PIR; T50082; T50082.
DR   RefSeq; NP_594320.2; NM_001019742.3.
DR   AlphaFoldDB; Q09189; -.
DR   SMR; Q09189; -.
DR   BioGRID; 278086; 5.
DR   STRING; 4896.SPAC1556.03.1; -.
DR   MaxQB; Q09189; -.
DR   PaxDb; Q09189; -.
DR   EnsemblFungi; SPAC1556.03.1; SPAC1556.03.1:pep; SPAC1556.03.
DR   GeneID; 2541589; -.
DR   KEGG; spo:SPAC1556.03; -.
DR   PomBase; SPAC1556.03; azr1.
DR   VEuPathDB; FungiDB:SPAC1556.03; -.
DR   eggNOG; KOG1379; Eukaryota.
DR   HOGENOM; CLU_029404_3_0_1; -.
DR   InParanoid; Q09189; -.
DR   OMA; MQSIYWT; -.
DR   PhylomeDB; Q09189; -.
DR   PRO; PR:Q09189; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; ISS:PomBase.
DR   GO; GO:1904775; P:positive regulation of ubiquinone biosynthetic process; TAS:PomBase.
DR   GO; GO:0023052; P:signaling; NAS:PomBase.
DR   CDD; cd00143; PP2Cc; 1.
DR   Gene3D; 3.60.40.10; -; 2.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   InterPro; IPR039123; PPTC7.
DR   PANTHER; PTHR12320; PTHR12320; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..299
FT                   /note="5-azacytidine resistance protein azr1"
FT                   /id="PRO_0000064784"
FT   DOMAIN          35..293
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
SQ   SEQUENCE   299 AA;  33063 MW;  0B538B3DC3924A60 CRC64;
     MNVTRLYFRV AGTKQFARYV HKYAAYSSTS FQKKKSHFPS PATLDHPDAG EDAFINLRNE
     NYILNAVFDG VGGWANVGID PSIFSWGLVR EIKKVFNNSD EFQPSPLTLL SKAYAALKKS
     NTVEAGSSTA CLTLFNCGNG KLHSLNLGDS GFLILRNGAI HYASPAQVLQ FNMPYQLAIY
     PRNYRSAENI GPKMGQATVH DLKDNDLVIL ATDGIFDNIE EKSILDIAGV VDFSSLSNVQ
     KCLDDLAMRI CRQAVLNSLD TKWESPFAKT AKSFGFKFQG GKVDDTTITC LLIKSKNYE