ID   RS15A_DANRE             Reviewed;         130 AA.
AC   Q6Q420;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=40S ribosomal protein S15a {ECO:0000250|UniProtKB:P62244};
GN   Name=rps15a {ECO:0000312|ZFIN:ZDB-GENE-030131-8708};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15138505; DOI=10.1371/journal.pbio.0020139;
RA   Amsterdam A., Sadler K.C., Lai K., Farrington S., Bronson R.T., Lees J.A.,
RA   Hopkins N.;
RT   "Many ribosomal protein genes are cancer genes in zebrafish.";
RL   PLoS Biol. 2:690-698(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27909223; DOI=10.3324/haematol.2016.153932;
RA   Ikeda F., Yoshida K., Toki T., Uechi T., Ishida S., Nakajima Y.,
RA   Sasahara Y., Okuno Y., Kanezaki R., Terui K., Kamio T., Kobayashi A.,
RA   Fujita T., Sato-Otsubo A., Shiraishi Y., Tanaka H., Chiba K., Muramatsu H.,
RA   Kanno H., Ohga S., Ohara A., Kojima S., Kenmochi N., Miyano S., Ogawa S.,
RA   Ito E.;
RT   "Exome sequencing identified RPS15A as a novel causative gene for Diamond-
RT   Blackfan anemia.";
RL   Haematologica 102:E93-E96(2017).
CC   -!- FUNCTION: Structural component of the ribosome (By similarity).
CC       Required for erythropoiesis during embryonic development
CC       (PubMed:27909223). {ECO:0000250|UniProtKB:P62244,
CC       ECO:0000269|PubMed:27909223}.
CC   -!- SUBUNIT: Component of the 40S ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P62244}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino-injected embryos have a thin yolk sac,
CC       bent tail, and show a marked decrease of erythrocyte production.
CC       {ECO:0000269|PubMed:27909223}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS8 family.
CC       {ECO:0000305}.
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DR   EMBL; AY561512; AAS66965.1; -; mRNA.
DR   EMBL; CR450821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC107523; AAI07524.1; -; mRNA.
DR   RefSeq; NP_997927.1; NM_212762.1.
DR   AlphaFoldDB; Q6Q420; -.
DR   SMR; Q6Q420; -.
DR   STRING; 7955.ENSDARP00000108197; -.
DR   PaxDb; Q6Q420; -.
DR   PRIDE; Q6Q420; -.
DR   Ensembl; ENSDART00000128613; ENSDARP00000108197; ENSDARG00000010160.
DR   Ensembl; ENSDART00000172555; ENSDARP00000134460; ENSDARG00000010160.
DR   GeneID; 336764; -.
DR   KEGG; dre:336764; -.
DR   CTD; 6210; -.
DR   ZFIN; ZDB-GENE-030131-8708; rps15a.
DR   eggNOG; KOG1754; Eukaryota.
DR   GeneTree; ENSGT00950000183198; -.
DR   HOGENOM; CLU_098428_1_1_1; -.
DR   InParanoid; Q6Q420; -.
DR   OMA; LPAKNFG; -.
DR   OrthoDB; 1417658at2759; -.
DR   PhylomeDB; Q6Q420; -.
DR   TreeFam; TF300067; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72649; Translation initiation complex formation.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q6Q420; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000010160; Expressed in testis and 28 other tissues.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IMP:ZFIN.
DR   GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR   GO; GO:0030218; P:erythrocyte differentiation; IMP:ZFIN.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_01302_A; Ribosomal_S8_A; 1.
DR   InterPro; IPR000630; Ribosomal_S8.
DR   InterPro; IPR035987; Ribosomal_S8_sf.
DR   PANTHER; PTHR11758; PTHR11758; 1.
DR   Pfam; PF00410; Ribosomal_S8; 1.
DR   SUPFAM; SSF56047; SSF56047; 1.
DR   PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..130
FT                   /note="40S ribosomal protein S15a"
FT                   /id="PRO_0000447680"
SQ   SEQUENCE   130 AA;  14840 MW;  D4E90AD921F3E083 CRC64;
     MVRMNVLADA LKSINNAEKR GKRQVLLRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
     IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
     TGGKILGFFF