RS15A_DROME
ID RS15A_DROME Reviewed; 130 AA.
AC P48149; A4V4D9; Q9VYE4;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=40S ribosomal protein S15Aa;
GN Name=RpS15Aa; Synonyms=RpS15A; ORFNames=CG2033;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-R;
RX PubMed=8182070; DOI=10.1016/s0021-9258(17)36670-x;
RA Lavoie C., Tam R., Clark M., Lee H., Sonenberg N., Lasko P.;
RT "Suppression of a temperature-sensitive cdc33 mutation of yeast by a
RT multicopy plasmid expressing a Drosophila ribosomal protein.";
RL J. Biol. Chem. 269:14625-14630(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS8 family.
CC {ECO:0000305}.
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DR EMBL; Z21673; CAA79771.1; -; mRNA.
DR EMBL; AE014298; AAF48256.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF48257.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09322.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09323.1; -; Genomic_DNA.
DR EMBL; AY084182; AAL89920.1; -; mRNA.
DR PIR; S33498; S33498.
DR RefSeq; NP_001162738.1; NM_001169267.2.
DR RefSeq; NP_524709.1; NM_079970.6.
DR RefSeq; NP_727690.1; NM_167360.3.
DR RefSeq; NP_727692.1; NM_167362.3.
DR RefSeq; NP_727693.1; NM_167363.3.
DR PDB; 4V6W; EM; 6.00 A; AW=1-130.
DR PDB; 6XU6; EM; 3.50 A; AW=2-130.
DR PDB; 6XU7; EM; 4.90 A; AW=2-130.
DR PDB; 6XU8; EM; 3.00 A; AW=2-130.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; P48149; -.
DR SMR; P48149; -.
DR BioGRID; 68867; 110.
DR DIP; DIP-17180N; -.
DR IntAct; P48149; 7.
DR STRING; 7227.FBpp0073623; -.
DR PaxDb; P48149; -.
DR PRIDE; P48149; -.
DR DNASU; 44150; -.
DR EnsemblMetazoa; FBtr0073792; FBpp0073623; FBgn0010198.
DR EnsemblMetazoa; FBtr0073793; FBpp0073624; FBgn0010198.
DR EnsemblMetazoa; FBtr0073794; FBpp0073625; FBgn0010198.
DR EnsemblMetazoa; FBtr0073795; FBpp0073626; FBgn0010198.
DR EnsemblMetazoa; FBtr0300828; FBpp0290052; FBgn0010198.
DR GeneID; 44150; -.
DR KEGG; dme:Dmel_CG2033; -.
DR CTD; 44150; -.
DR FlyBase; FBgn0010198; RpS15Aa.
DR VEuPathDB; VectorBase:FBgn0010198; -.
DR eggNOG; KOG1754; Eukaryota.
DR GeneTree; ENSGT00950000183198; -.
DR HOGENOM; CLU_098428_1_1_1; -.
DR InParanoid; P48149; -.
DR OMA; LPAKNFG; -.
DR OrthoDB; 1417658at2759; -.
DR PhylomeDB; P48149; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DME-72649; Translation initiation complex formation.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DME-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P48149; -.
DR BioGRID-ORCS; 44150; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 44150; -.
DR PRO; PR:P48149; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0010198; Expressed in ovary and 11 other tissues.
DR ExpressionAtlas; P48149; baseline and differential.
DR Genevisible; P48149; DM.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR InterPro; IPR000630; Ribosomal_S8.
DR InterPro; IPR035987; Ribosomal_S8_sf.
DR PANTHER; PTHR11758; PTHR11758; 1.
DR Pfam; PF00410; Ribosomal_S8; 1.
DR SUPFAM; SSF56047; SSF56047; 1.
DR PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..130
FT /note="40S ribosomal protein S15Aa"
FT /id="PRO_0000126609"
SQ SEQUENCE 130 AA; 14771 MW; 41392F8F505DED09 CRC64;
MVRMNVLADA LKCINNAEKR GKRQVLLRPC SKVIIKFLTV MMKHGYIGEF EIVDDHRSGK
IVVNLTGRLN KCGVISPRFD VPINDIEKWT NNLLPSRQFG YVVLTTSGGI MDHEEARRKH
LGGKILGFFF
