RS15A_MOUSE
ID RS15A_MOUSE Reviewed; 130 AA.
AC P62245; P39027; P39031; Q8C023; Q9BV24;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=40S ribosomal protein S15a;
GN Name=Rps15a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Embryo, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-88, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Structural component of the ribosome. Required for proper
CC erythropoiesis. {ECO:0000250|UniProtKB:P62244}.
CC -!- SUBUNIT: Component of the 40S ribosomal subunit.
CC {ECO:0000250|UniProtKB:P62244}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS8 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH51205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC051205; AAH51205.1; ALT_INIT; mRNA.
DR EMBL; BC054792; AAH54792.1; -; mRNA.
DR EMBL; BC055697; AAH55697.1; -; mRNA.
DR EMBL; BC076563; AAH76563.1; -; mRNA.
DR EMBL; BC081428; AAH81428.1; -; mRNA.
DR EMBL; AK010652; BAB27092.1; -; mRNA.
DR EMBL; AK011514; BAB27669.1; -; mRNA.
DR EMBL; AK012485; BAB28272.1; -; mRNA.
DR EMBL; AK012618; BAB28359.1; -; mRNA.
DR EMBL; AK019235; BAB31617.1; -; mRNA.
DR EMBL; AK028135; BAC25764.1; -; mRNA.
DR EMBL; AK032522; BAC27909.1; -; mRNA.
DR CCDS; CCDS21768.1; -.
DR RefSeq; NP_733769.1; NM_170669.2.
DR PDB; 7CPU; EM; 2.82 A; SW=1-130.
DR PDB; 7CPV; EM; 3.03 A; SW=1-130.
DR PDB; 7LS1; EM; 3.30 A; P3=1-130.
DR PDB; 7LS2; EM; 3.10 A; P3=1-130.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P62245; -.
DR SMR; P62245; -.
DR BioGRID; 234473; 74.
DR ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR IntAct; P62245; 3.
DR STRING; 10090.ENSMUSP00000119975; -.
DR iPTMnet; P62245; -.
DR PhosphoSitePlus; P62245; -.
DR SwissPalm; P62245; -.
DR EPD; P62245; -.
DR jPOST; P62245; -.
DR PaxDb; P62245; -.
DR PeptideAtlas; P62245; -.
DR PRIDE; P62245; -.
DR ProteomicsDB; 262711; -.
DR TopDownProteomics; P62245; -.
DR Antibodypedia; 42904; 99 antibodies from 20 providers.
DR DNASU; 267019; -.
DR Ensembl; ENSMUST00000106588; ENSMUSP00000102198; ENSMUSG00000008683.
DR Ensembl; ENSMUST00000131374; ENSMUSP00000119975; ENSMUSG00000008683.
DR Ensembl; ENSMUST00000172457; ENSMUSP00000127791; ENSMUSG00000008683.
DR GeneID; 267019; -.
DR KEGG; mmu:267019; -.
DR UCSC; uc009jjn.1; mouse.
DR CTD; 6210; -.
DR MGI; MGI:2389091; Rps15a.
DR VEuPathDB; HostDB:ENSMUSG00000008683; -.
DR eggNOG; KOG1754; Eukaryota.
DR GeneTree; ENSGT00950000183198; -.
DR HOGENOM; CLU_098428_1_1_1; -.
DR InParanoid; P62245; -.
DR OMA; LPAKNFG; -.
DR OrthoDB; 1417658at2759; -.
DR PhylomeDB; P62245; -.
DR TreeFam; TF300067; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72649; Translation initiation complex formation.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 267019; 27 hits in 58 CRISPR screens.
DR ChiTaRS; Rps15a; mouse.
DR PRO; PR:P62245; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P62245; protein.
DR Bgee; ENSMUSG00000008683; Expressed in ventricular zone and 160 other tissues.
DR ExpressionAtlas; P62245; baseline and differential.
DR Genevisible; P62245; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0009615; P:response to virus; ISO:MGI.
DR HAMAP; MF_01302_A; Ribosomal_S8_A; 1.
DR InterPro; IPR000630; Ribosomal_S8.
DR InterPro; IPR035987; Ribosomal_S8_sf.
DR PANTHER; PTHR11758; PTHR11758; 1.
DR Pfam; PF00410; Ribosomal_S8; 1.
DR SUPFAM; SSF56047; SSF56047; 1.
DR PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..130
FT /note="40S ribosomal protein S15a"
FT /id="PRO_0000126603"
FT MOD_RES 88
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 14
FT /note="I -> N (in Ref. 1; BAC27909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14840 MW; D4AC1E8864E3A184 CRC64;
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
TGGKILGFFF
