RS15A_RAT
ID RS15A_RAT Reviewed; 130 AA.
AC P62246; P39027; P39031; Q8C023; Q9BV24;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=40S ribosomal protein S15a;
GN Name=Rps15a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-38.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8185605; DOI=10.1006/bbrc.1994.1620;
RA Chan Y.-L., Olvera J., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein S15a.";
RL Biochem. Biophys. Res. Commun. 200:1498-1504(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Structural component of the ribosome. Required for proper
CC erythropoiesis. {ECO:0000250|UniProtKB:P62244}.
CC -!- SUBUNIT: Component of the 40S ribosomal subunit.
CC {ECO:0000250|UniProtKB:P62244}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS8 family.
CC {ECO:0000305}.
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DR EMBL; X77953; CAA54918.1; -; mRNA.
DR EMBL; BC058452; AAH58452.1; -; mRNA.
DR PIR; JC2234; JC2234.
DR RefSeq; NP_446434.1; NM_053982.1.
DR RefSeq; XP_006230159.1; XM_006230097.2.
DR RefSeq; XP_006230160.1; XM_006230098.2.
DR AlphaFoldDB; P62246; -.
DR SMR; P62246; -.
DR BioGRID; 250650; 2.
DR IntAct; P62246; 3.
DR MINT; P62246; -.
DR STRING; 10116.ENSRNOP00000024678; -.
DR jPOST; P62246; -.
DR PaxDb; P62246; -.
DR PRIDE; P62246; -.
DR Ensembl; ENSRNOT00000092282; ENSRNOP00000075906; ENSRNOG00000018320.
DR GeneID; 117053; -.
DR KEGG; rno:117053; -.
DR UCSC; RGD:619939; rat.
DR CTD; 6210; -.
DR RGD; 619939; Rps15a.
DR VEuPathDB; HostDB:ENSRNOG00000067600; -.
DR eggNOG; KOG1754; Eukaryota.
DR GeneTree; ENSGT00950000183198; -.
DR HOGENOM; CLU_098428_1_1_1; -.
DR InParanoid; P62246; -.
DR OMA; LPAKNFG; -.
DR OrthoDB; 1417658at2759; -.
DR PhylomeDB; P62246; -.
DR TreeFam; TF300067; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62246; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000018320; Expressed in ovary and 19 other tissues.
DR Genevisible; P62246; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0009615; P:response to virus; ISO:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR HAMAP; MF_01302_A; Ribosomal_S8_A; 1.
DR InterPro; IPR000630; Ribosomal_S8.
DR InterPro; IPR035987; Ribosomal_S8_sf.
DR PANTHER; PTHR11758; PTHR11758; 1.
DR Pfam; PF00410; Ribosomal_S8; 1.
DR SUPFAM; SSF56047; SSF56047; 1.
DR PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8185605"
FT CHAIN 2..130
FT /note="40S ribosomal protein S15a"
FT /id="PRO_0000126604"
FT MOD_RES 88
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62245"
SQ SEQUENCE 130 AA; 14840 MW; D4AC1E8864E3A184 CRC64;
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
TGGKILGFFF
