RS15_CAEEL
ID RS15_CAEEL Reviewed; 151 AA.
AC Q9XVP0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=40S ribosomal protein S15;
GN Name=rps-15 {ECO:0000312|EMBL:CAB03065.1}; ORFNames=F36A2.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP PROTEIN SEQUENCE OF 2-13; 25-36; 59-65; 72-83 AND 88-106, ACETYLATION AT
RP ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RA Bienvenut W.V.;
RL Submitted (SEP-2005) to UniProtKB.
RN [3]
RP FUNCTION.
RX PubMed=23879233; DOI=10.1111/acel.12140;
RA Seo K., Choi E., Lee D., Jeong D.E., Jang S.K., Lee S.J.;
RT "Heat shock factor 1 mediates the longevity conferred by inhibition of TOR
RT and insulin/IGF-1 signaling pathways in C. elegans.";
RL Aging Cell 12:1073-1081(2013).
CC -!- FUNCTION: Negatively regulates lifespan. {ECO:0000269|PubMed:23879233}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS19 family.
CC {ECO:0000255}.
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DR EMBL; Z81077; CAB03065.1; -; Genomic_DNA.
DR PIR; T21828; T21828.
DR RefSeq; NP_492384.1; NM_059983.5.
DR AlphaFoldDB; Q9XVP0; -.
DR SMR; Q9XVP0; -.
DR BioGRID; 38126; 106.
DR IntAct; Q9XVP0; 11.
DR STRING; 6239.F36A2.6.1; -.
DR iPTMnet; Q9XVP0; -.
DR EPD; Q9XVP0; -.
DR PaxDb; Q9XVP0; -.
DR PeptideAtlas; Q9XVP0; -.
DR EnsemblMetazoa; F36A2.6.1; F36A2.6.1; WBGene00004484.
DR GeneID; 172693; -.
DR KEGG; cel:CELE_F36A2.6; -.
DR UCSC; F36A2.6.2; c. elegans.
DR CTD; 172693; -.
DR WormBase; F36A2.6; CE09945; WBGene00004484; rps-15.
DR eggNOG; KOG0898; Eukaryota.
DR GeneTree; ENSGT00390000000475; -.
DR HOGENOM; CLU_097347_1_0_1; -.
DR InParanoid; Q9XVP0; -.
DR OMA; VIRTHCR; -.
DR OrthoDB; 1390881at2759; -.
DR PhylomeDB; Q9XVP0; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q9XVP0; -.
DR PRO; PR:Q9XVP0; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00004484; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.860.10; -; 1.
DR HAMAP; MF_00531; Ribosomal_S19; 1.
DR InterPro; IPR020934; Ribosomal_S15/S19_CS.
DR InterPro; IPR002222; Ribosomal_S19.
DR InterPro; IPR023575; Ribosomal_S19_S15_SF.
DR InterPro; IPR005713; Ribosomal_S19A/S15e.
DR PANTHER; PTHR11880; PTHR11880; 1.
DR Pfam; PF00203; Ribosomal_S19; 1.
DR PIRSF; PIRSF002144; Ribosomal_S19; 1.
DR PRINTS; PR00975; RIBOSOMALS19.
DR SUPFAM; SSF54570; SSF54570; 1.
DR TIGRFAMs; TIGR01025; uS19_arch; 1.
DR PROSITE; PS00323; RIBOSOMAL_S19; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 2..151
FT /note="40S ribosomal protein S15"
FT /id="PRO_0000130037"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|Ref.2"
SQ SEQUENCE 151 AA; 17244 MW; 146D97D8669C100C CRC64;
MATQDDAHLA ELKKKRTFRK FMYRGVDLDQ LLDMSREQFT KLLPCRMRRR LDRGLKRKHL
ALIAKVQKAK KAAGVLEKPA TVKTHLRDMI ILPELVGGVI GIYNGKVFNQ TEIKPEMIGF
YLGEFAISYK PVKHGRPGIG ATHSSRFIPL K
