B12A_TETBN
ID B12A_TETBN Reviewed; 68 AA.
AC A0A088SG62;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=U-myrmicitoxin(01)-Tb2a {ECO:0000305};
DE Short=MYRTX(01)-Tb2 {ECO:0000303|PubMed:30214940};
DE Short=U-MYRTX(01)-Tb2a {ECO:0000305};
DE AltName: Full=Ant peptide P17 {ECO:0000312|EMBL:AIO11144.1};
DE AltName: Full=U1-myrmicitoxin-Tb2a {ECO:0000303|PubMed:26805882};
DE Short=U1-MYRTX-Tb2a {ECO:0000303|PubMed:26805882};
DE Flags: Precursor;
OS Tetramorium bicarinatum (Tramp ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Tetramorium.
OX NCBI_TaxID=219812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=23584016; DOI=10.1016/j.toxicon.2013.03.010;
RA Bouzid W., Klopp C., Verdenaud M., Ducancel F., Vetillard A.;
RT "Profiling the venom gland transcriptome of Tetramorium bicarinatum
RT (Hymenoptera: Formicidae): the first transcriptome analysis of an ant
RT species.";
RL Toxicon 70:70-81(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RA Bonnafe E., Allaoua M., Rifflet A., Treilhou M.;
RT "Cloning of total p17 cDNA using a modified RACE PCR strategy.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 53-65, SYNTHESIS OF 53-65, FUNCTION, MASS SPECTROMETRY,
RP AMIDATION AT LEU-65, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=22960382; DOI=10.1016/j.peptides.2012.08.018;
RA Rifflet A., Gavalda S., Tene N., Orivel J., Leprince J., Guilhaudis L.,
RA Genin E., Vetillard A., Treilhou M.;
RT "Identification and characterization of a novel antimicrobial peptide from
RT the venom of the ant Tetramorium bicarinatum.";
RL Peptides 38:363-370(2012).
RN [4]
RP REVIEW, AND NOMENCLATURE.
RX PubMed=26805882; DOI=10.3390/toxins8010030;
RA Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA Dejean A.;
RT "The biochemical toxin arsenal from ant venoms.";
RL Toxins 8:1-28(2016).
RN [5]
RP NOMENCLATURE.
RX PubMed=30214940; DOI=10.1126/sciadv.aau4640;
RA Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R.,
RA Payne R.J., Vetter I., King G.F., Undheim E.A.B.;
RT "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia
RT gulosa, reveals a hyperdiverse hymenopteran toxin gene family.";
RL Sci. Adv. 4:EAAU4640-EAAU4640(2018).
CC -!- FUNCTION: Unknown. Does not show antimicrobial activity when tested on
CC S.aureus and S.xylosus (Ref.2). Does not show hemolytic activity
CC (Ref.2). {ECO:0000269|Ref.2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22960382}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:22960382}.
CC -!- MASS SPECTROMETRY: Mass=1571.49; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:22960382};
CC -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC {ECO:0000305}.
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DR EMBL; JZ168552; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; KM030176; AIO11144.1; -; mRNA.
DR AlphaFoldDB; A0A088SG62; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..52
FT /evidence="ECO:0000305|PubMed:22960382"
FT /id="PRO_0000447050"
FT PEPTIDE 53..65
FT /note="U-myrmicitoxin(01)-Tb2a"
FT /evidence="ECO:0000305"
FT /id="PRO_5001839399"
FT MOD_RES 65
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:22960382"
SQ SEQUENCE 68 AA; 7103 MW; DE1491BAB9E26129 CRC64;
MKLSFLSLAL ATIFVMAIIY APQMEARASS DADADAAASA DADADALAEA SALFKEILEK
IKAKLGKK
