ID   B14_VACCC               Reviewed;         149 AA.
AC   P21089;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Protein B14;
DE   AltName: Full=Protein B15;
GN   ORFNames=B15R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Contributes to virulence by binding to the host IKBKB subunit
CC       of the IKK complex and preventing host NF-kappa-B activation in
CC       response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimers. Interaction with host IKBKB; this interaction
CC       inhibits host NF-kappa-B activation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus B14 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48212.1; -; Genomic_DNA.
DR   PIR; E42527; E42527.
DR   SMR; P21089; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR011212; Poxvirus_B14/B22/C16.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF017324; UCP017324; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Protein B14"
FT                   /id="PRO_0000099364"
SQ   SEQUENCE   149 AA;  17384 MW;  B13DE8D60F671973 CRC64;
     MTANFSTHVF SPQHCGCDRL TSIDDVKQCL TEYIYWSSYA YRNRQCAGQL YSTLLSFRDD
     AELVFIDIRE LVKNMPWDDV KDCTEIIRCY IPDEQKTIRE ISAIIGLCAY AATYWGGEDH
     PTSNSLNALF VMLEMLNYVD YNIIFRRMN