ID   B14_VAR67               Reviewed;         149 AA.
AC   P0DSV9; P33877;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Protein B14;
GN   ORFNames=B13R, B14R, B15R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Contributes to virulence by binding to the host IKBKB subunit
CC       of the IKK complex and preventing host NF-kappa-B activation in
CC       response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimers. Interaction with host IKBKB; this interaction
CC       inhibits host NF-kappa-B activation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae B14 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49123.1; -; Genomic_DNA.
DR   EMBL; X67117; CAA47524.1; -; Genomic_DNA.
DR   PIR; E36856; E36856.
DR   RefSeq; NP_042226.1; NC_001611.1.
DR   SMR; P0DSV9; -.
DR   GeneID; 1486544; -.
DR   KEGG; vg:1486544; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR011212; Poxvirus_B14/B22/C16.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF017324; UCP017324; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Protein B14"
FT                   /id="PRO_0000099366"
SQ   SEQUENCE   149 AA;  17369 MW;  A84910243C7ED3D4 CRC64;
     MTANFSTHVF SPQHCGCDRL TSIDDVRQCL TEYIYWSSYA YRNRQCAGQL YSTLLSFRDD
     AESVFIDVRE LVKNMPWDDV KDCVEIIRCY IPDEQKTIRE ISAIIGLCAY AATYWGGEDH
     PTSNSLNALF VMLKMLNYVD YNIIFRRMN