ID   B14_VARV                Reviewed;         149 AA.
AC   P0DSW0; P33877;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Protein B14;
GN   ORFNames=B13R, B14R, B15R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Somalia-1977;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to virulence by binding to the host IKBKB subunit
CC       of the IKK complex and preventing host NF-kappa-B activation in
CC       response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimers. Interaction with host IKBKB; this interaction
CC       inhibits host NF-kappa-B activation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae B14 protein family.
CC       {ECO:0000305}.
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DR   EMBL; L22579; AAA60922.1; -; Genomic_DNA.
DR   EMBL; U18341; AAA69454.1; -; Genomic_DNA.
DR   PIR; E36856; E36856.
DR   PIR; T28612; T28612.
DR   RefSeq; NP_042226.1; NC_001611.1.
DR   SMR; P0DSW0; -.
DR   GeneID; 1486544; -.
DR   KEGG; vg:1486544; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR011212; Poxvirus_B14/B22/C16.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF017324; UCP017324; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus.
FT   CHAIN           1..149
FT                   /note="Protein B14"
FT                   /id="PRO_0000448170"
SQ   SEQUENCE   149 AA;  17369 MW;  A84910243C7ED3D4 CRC64;
     MTANFSTHVF SPQHCGCDRL TSIDDVRQCL TEYIYWSSYA YRNRQCAGQL YSTLLSFRDD
     AESVFIDVRE LVKNMPWDDV KDCVEIIRCY IPDEQKTIRE ISAIIGLCAY AATYWGGEDH
     PTSNSLNALF VMLKMLNYVD YNIIFRRMN