B18_VACCW
ID B18_VACCW Reviewed; 351 AA.
AC P25213; Q76ZK5;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 02-JUN-2021, entry version 102.
DE RecName: Full=Soluble interferon alpha/beta receptor B18;
DE Short=B18;
DE Flags: Precursor;
GN OrderedLocusNames=VACWR200; ORFNames=B18R;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA Smith G.L., Chan Y.S., Howard S.T.;
RT "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT right inverted terminal repeat.";
RL J. Gen. Virol. 72:1349-1376(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1826022; DOI=10.1099/0022-1317-72-3-511;
RA Smith G.L., Chan Y.S.;
RT "Two vaccinia virus proteins structurally related to the interleukin-1
RT receptor and the immunoglobulin superfamily.";
RL J. Gen. Virol. 72:511-518(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH MOUSE IFNA1.
RX PubMed=7758109; DOI=10.1016/0092-8674(95)90076-4;
RA Symons J.A., Alcami A., Smith G.L.;
RT "Vaccinia virus encodes a soluble type I interferon receptor of novel
RT structure and broad species specificity.";
RL Cell 81:551-560(1995).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=11070021; DOI=10.1128/jvi.74.23.11230-11239.2000;
RA Alcami A., Symons J.A., Smith G.L.;
RT "The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to
RT the cell surface and protects cells from the antiviral effects of IFN.";
RL J. Virol. 74:11230-11239(2000).
RN [6]
RP FUNCTION.
RX PubMed=19073732; DOI=10.1128/jvi.01617-08;
RA Waibler Z., Anzaghe M., Frenz T., Schwantes A., Pohlmann C., Ludwig H.,
RA Palomo-Otero M., Alcami A., Sutter G., Kalinke U.;
RT "Vaccinia virus-mediated inhibition of type I interferon responses is a
RT multifactorial process involving the soluble type I interferon receptor B18
RT and intracellular components.";
RL J. Virol. 83:1563-1571(2009).
CC -!- FUNCTION: Counteracts the antiviral effects of host IFN-alpha/beta.
CC Acts as a soluble IFN-alpha receptor and thus inhibits the interaction
CC between host IFN-alpha and its receptor. {ECO:0000269|PubMed:19073732}.
CC -!- SUBUNIT: Interacts with mouse Ifna1. {ECO:0000269|PubMed:7758109}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11070021}.
CC Note=Found associated with both uninfected and infected host cell
CC membranes after secretion.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000305}.
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DR EMBL; D11079; BAA01848.1; -; Genomic_DNA.
DR EMBL; D01019; BAA00826.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89479.1; -; Genomic_DNA.
DR PIR; B38472; SAVZWR.
DR RefSeq; YP_233082.1; NC_006998.1.
DR SMR; P25213; -.
DR DNASU; 3707577; -.
DR GeneID; 3707577; -.
DR KEGG; vg:3707577; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11890; PTHR11890; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Early protein; Glycoprotein; Host-virus interaction;
KW Immunoglobulin domain; Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Reference proteome; Repeat; Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..351
FT /note="Soluble interferon alpha/beta receptor B18"
FT /id="PRO_0000015467"
FT DOMAIN 65..147
FT /note="Ig-like C2-type 1"
FT DOMAIN 155..237
FT /note="Ig-like C2-type 2"
FT DOMAIN 246..345
FT /note="Ig-like V-type"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 321
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 73..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 172..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 272..333
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 351 AA; 40732 MW; 73BFD6EA1EF73F91 CRC64;
MTMKMMVHIY FVSLLLLLFH SYAIDIENEI TEFFNKMRDT LPAKDSKWLN PACMFGGTMN
DIAALGEPFS AKCPPIEDSL LSHRYKDYVV KWERLEKNRR RQVSNKRVKH GDLWIANYTS
KFSNRRYLCT VTTKNGDCVQ GIVRSHIRKP PSCIPKTYEL GTHDKYGIDL YCGILYAKHY
NNITWYKDNK EINIDDIKYS QTGKELIIHN PELEDSGRYD CYVHYDDVRI KNDIVVSRCK
ILTVIPSQDH RFKLILDPKI NVTIGEPANI TCTAVSTSLL IDDVLIEWEN PSGWLIGFDF
DVYSVLTSRG GITEATLYFE NVTEEYIGNT YKCRGHNYYF EKTLTTTVVL E
