RS15_HELPY
ID RS15_HELPY Reviewed; 90 AA.
AC P56022; Q9X5H2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=30S ribosomal protein S15 {ECO:0000255|HAMAP-Rule:MF_01343};
GN Name=rpsO {ECO:0000255|HAMAP-Rule:MF_01343}; OrderedLocusNames=HP_1040;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43504;
RX PubMed=10198012; DOI=10.1128/jb.181.8.2477-2484.1999;
RA McGee D.J., May C.A., Garner R.M., Himpsl J.M., Mobley H.L.T.;
RT "Isolation of Helicobacter pylori genes that modulate urease activity.";
RL J. Bacteriol. 181:2477-2484(1999).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it helps nucleate assembly of the platform of the 30S
CC subunit by binding and bridging several RNA helices of the 16S rRNA.
CC {ECO:0000255|HAMAP-Rule:MF_01343}.
CC -!- FUNCTION: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of
CC the 50S subunit in the ribosome. {ECO:0000255|HAMAP-Rule:MF_01343}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Forms a bridge to the 50S
CC subunit in the 70S ribosome, contacting the 23S rRNA.
CC {ECO:0000255|HAMAP-Rule:MF_01343}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS15 family.
CC {ECO:0000255|HAMAP-Rule:MF_01343}.
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DR EMBL; AE000511; AAD08082.1; -; Genomic_DNA.
DR EMBL; AF125197; AAD27688.1; -; Genomic_DNA.
DR PIR; H64649; H64649.
DR RefSeq; NP_207830.1; NC_000915.1.
DR RefSeq; WP_001207122.1; NC_018939.1.
DR AlphaFoldDB; P56022; -.
DR SMR; P56022; -.
DR IntAct; P56022; 2.
DR STRING; 85962.C694_05380; -.
DR PaxDb; P56022; -.
DR EnsemblBacteria; AAD08082; AAD08082; HP_1040.
DR KEGG; hpy:HP_1040; -.
DR PATRIC; fig|85962.47.peg.1119; -.
DR eggNOG; COG0184; Bacteria.
DR OMA; FKTHVKD; -.
DR PhylomeDB; P56022; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00353; Ribosomal_S15p_S13e; 1.
DR HAMAP; MF_01343_B; Ribosomal_S15_B; 1.
DR InterPro; IPR000589; Ribosomal_S15.
DR InterPro; IPR005290; Ribosomal_S15_bac-type.
DR InterPro; IPR009068; S15_NS1_RNA-bd.
DR PANTHER; PTHR23321; PTHR23321; 1.
DR Pfam; PF00312; Ribosomal_S15; 1.
DR SMART; SM01387; Ribosomal_S15; 1.
DR SUPFAM; SSF47060; SSF47060; 1.
DR TIGRFAMs; TIGR00952; S15_bact; 1.
DR PROSITE; PS00362; RIBOSOMAL_S15; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT CHAIN 1..90
FT /note="30S ribosomal protein S15"
FT /id="PRO_0000115450"
FT VARIANT 19
FT /note="E -> Q (in strain: ATCC 43504)"
FT VARIANT 37
FT /note="K -> R (in strain: ATCC 43504)"
FT VARIANT 74
FT /note="N -> D (in strain: ATCC 43504)"
SQ SEQUENCE 90 AA; 10390 MW; 298BE06819002481 CRC64;
MALNLEKKQE IIKAFATKEN DTGSCEVQVA LLNERIKLLT EHLKANPKDH SSRLGLLKLV
AQRRNLLKYI KRTNHARYVV LIEKLGIKDR