ID   B19_VACCW               Reviewed;         574 AA.
AC   Q01222; Q76ZK6;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 91.
DE   RecName: Full=Ankyrin repeat protein B19;
GN   OrderedLocusNames=VACWR199; ORFNames=B19R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA   Smith G.L., Chan Y.S., Howard S.T.;
RT   "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT   right inverted terminal repeat.";
RL   J. Gen. Virol. 72:1349-1376(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the poxvirinae B18 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D11079; BAA01847.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89478.1; -; Genomic_DNA.
DR   PIR; JQ1811; JQ1811.
DR   RefSeq; YP_233081.1; NC_006998.1.
DR   SMR; Q01222; -.
DR   PRIDE; Q01222; -.
DR   DNASU; 3707576; -.
DR   GeneID; 3707576; -.
DR   KEGG; vg:3707576; -.
DR   PRO; PR:Q01222; -.
DR   Proteomes; UP000000344; Genome.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF13606; Ank_3; 1.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..574
FT                   /note="Ankyrin repeat protein B19"
FT                   /id="PRO_0000067090"
FT   REPEAT          56..87
FT                   /note="ANK 1"
FT   REPEAT          135..164
FT                   /note="ANK 2"
FT   REPEAT          167..213
FT                   /note="ANK 3"
FT   REPEAT          217..249
FT                   /note="ANK 4"
FT   REPEAT          253..285
FT                   /note="ANK 5"
FT   REPEAT          327..356
FT                   /note="ANK 6"
FT   DOMAIN          541..574
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   574 AA;  67987 MW;  A9D85B8D1D52417F CRC64;
     MSRRLIYVLN INRESTHKIQ ENEIYTYFSH CNIDHTSTEL DFVVKNYDLN RRQPVTGYTA
     LHCYLYNNYF TNDVLKILLN HGVDVTMKTS SGRMPVYILL TRCCNISHDV VIDMIDKDKN
     HLLHRDYSNL LLEYIKSRYM LLKEEDIDEN IVSTLLDKGI DPNFKQDGYT ALHYYYLCLA
     HVYKPGECRK PITIKKAKRI ISLFIQHGAN LNALDNCGNT PFHLYLSIEM CNNIHMTKML
     LTFNPNFEIC NNHGLTPILC YITSDYIQHD ILVMLIHHYE TNVGEMPIDE RRIIVFEFIK
     TYSTRPADSI TYLMNRFKNI DIYTRYEGKT LLHVACEYNN THVIDYLIRI NGDINALTDN
     NKHATQLIID NKENSPYTIN CLLYILRYIV DKNVIRSLVD QLPSLPIFDI KSFEKFISYC
     ILLDDTFYNR HVRNRDSKTY RYAFSKYMSF DKYDGIITKC HKETILLKLS TVLDTTLYAV
     LRCHNSKKLR RYLTELKKYN NDKSFKIYSN IMNERYLNVY YKDMYVSKVY DKLFPVFTDK
     NCLLTLLPSE IIYEILYMLT INDLYNISYP PTKV