RS15_MOUSE
ID RS15_MOUSE Reviewed; 145 AA.
AC P62843; P11174; Q52KC9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=40S ribosomal protein S15;
DE AltName: Full=RIG protein;
GN Name=Rps15; Synonyms=Rig;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2154983; DOI=10.1016/0006-291x(90)91037-s;
RA Sugawara A., Nata K., Inoue C., Takasawa S., Yamamoto H., Okamoto H.;
RT "Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig
RT cDNAs: the rig-encoded protein is extremely conserved during vertebrate
RT evolution.";
RL Biochem. Biophys. Res. Commun. 166:1501-1507(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Kidney, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS19 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M33330; AAA40055.1; -; mRNA.
DR EMBL; BC010763; AAH10763.1; -; mRNA.
DR EMBL; BC094409; AAH94409.1; -; mRNA.
DR CCDS; CCDS35978.1; -.
DR PIR; A34823; A34823.
DR RefSeq; NP_033117.1; NM_009091.2.
DR PDB; 7CPU; EM; 2.82 A; SP=1-145.
DR PDB; 7CPV; EM; 3.03 A; SP=1-145.
DR PDB; 7LS1; EM; 3.30 A; x2=1-145.
DR PDB; 7LS2; EM; 3.10 A; x2=1-145.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P62843; -.
DR SMR; P62843; -.
DR BioGRID; 203003; 63.
DR ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR IntAct; P62843; 5.
DR MINT; P62843; -.
DR STRING; 10090.ENSMUSP00000069004; -.
DR iPTMnet; P62843; -.
DR PhosphoSitePlus; P62843; -.
DR EPD; P62843; -.
DR jPOST; P62843; -.
DR MaxQB; P62843; -.
DR PaxDb; P62843; -.
DR PeptideAtlas; P62843; -.
DR PRIDE; P62843; -.
DR ProteomicsDB; 299937; -.
DR TopDownProteomics; P62843; -.
DR Antibodypedia; 22700; 220 antibodies from 28 providers.
DR DNASU; 20054; -.
DR Ensembl; ENSMUST00000068408; ENSMUSP00000069004; ENSMUSG00000063457.
DR GeneID; 20054; -.
DR KEGG; mmu:20054; -.
DR UCSC; uc007gcn.2; mouse.
DR CTD; 6209; -.
DR MGI; MGI:98117; Rps15.
DR VEuPathDB; HostDB:ENSMUSG00000063457; -.
DR eggNOG; KOG0898; Eukaryota.
DR GeneTree; ENSGT00390000000475; -.
DR InParanoid; P62843; -.
DR OMA; VIRTHCR; -.
DR OrthoDB; 1390881at2759; -.
DR PhylomeDB; P62843; -.
DR TreeFam; TF318650; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72649; Translation initiation complex formation.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 20054; 27 hits in 52 CRISPR screens.
DR ChiTaRS; Rps15; mouse.
DR PRO; PR:P62843; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P62843; protein.
DR Bgee; ENSMUSG00000063457; Expressed in mammary bud and 243 other tissues.
DR ExpressionAtlas; P62843; baseline and differential.
DR Genevisible; P62843; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0045202; C:synapse; ISO:MGI.
DR GO; GO:0097371; F:MDM2/MDM4 family protein binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; ISO:MGI.
DR GO; GO:0000028; P:ribosomal small subunit assembly; ISO:MGI.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; ISO:MGI.
DR Gene3D; 3.30.860.10; -; 1.
DR HAMAP; MF_00531; Ribosomal_S19; 1.
DR InterPro; IPR020934; Ribosomal_S15/S19_CS.
DR InterPro; IPR002222; Ribosomal_S19.
DR InterPro; IPR023575; Ribosomal_S19_S15_SF.
DR InterPro; IPR005713; Ribosomal_S19A/S15e.
DR PANTHER; PTHR11880; PTHR11880; 1.
DR Pfam; PF00203; Ribosomal_S19; 1.
DR PIRSF; PIRSF002144; Ribosomal_S19; 1.
DR PRINTS; PR00975; RIBOSOMALS19.
DR SUPFAM; SSF54570; SSF54570; 1.
DR TIGRFAMs; TIGR01025; uS19_arch; 1.
DR PROSITE; PS00323; RIBOSOMAL_S19; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Isopeptide bond; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62841"
FT CHAIN 2..145
FT /note="40S ribosomal protein S15"
FT /id="PRO_0000130029"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P62841"
FT CROSSLNK 108
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62841"
SQ SEQUENCE 145 AA; 17040 MW; CA2C682302C7B387 CRC64;
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL
RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS
ITYKPVKHGR PGIGATHSSR FIPLK