ID   B1JDA_ODOJI             Reviewed;          24 AA.
AC   B3A0M4;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Brevinin-1JDa {ECO:0000303|PubMed:22917879};
OS   Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=431936;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, PROBABLE FUNCTION, SUBCELLULAR LOCATION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:22917879};
RX   PubMed=22917879; DOI=10.1016/j.jprot.2012.08.004;
RA   Liu J., Jiang J., Wu Z., Xie F.;
RT   "Antimicrobial peptides from the skin of the Asian frog, Odorrana
RT   jingdongensis: De novo sequencing and analysis of tandem mass spectrometry
RT   data.";
RL   J. Proteomics 75:5807-5821(2012).
CC   -!- FUNCTION: Has antibacterial activity against E.coli and S.aureus
CC       strains. Has antifungal activity against C.albicans. Has hemolytic
CC       activity against rabbit erythrocytes (Probable).
CC       {ECO:0000269|PubMed:22917879, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22917879}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:22917879}.
CC   -!- MASS SPECTROMETRY: Mass=2558.4376; Mass_error=0.001;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:22917879};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; B3A0M4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012520; Antimicrobial_frog_1.
DR   Pfam; PF08018; Antimicrobial_1; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Disulfide bond; Fungicide; Hemolysis; Secreted.
FT   PEPTIDE         1..24
FT                   /note="Brevinin-1JDa"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT                   /id="PRO_0000420136"
FT   DISULFID        18..24
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          2
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          6
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          13
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          20
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:22917879"
SQ   SEQUENCE   24 AA;  2561 MW;  C2F3F638B9C31CF4 CRC64;
     FLPAVIRVAA NVLPTVFCAI SKKC