RS15_RAT
ID RS15_RAT Reviewed; 145 AA.
AC P62845; P11174;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=40S ribosomal protein S15;
DE AltName: Full=RIG protein;
GN Name=Rps15; Synonyms=Rig;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3019805; DOI=10.2337/diab.35.10.1178;
RA Takasawa S., Yamamoto H., Terazono K., Okamoto H.;
RT "Novel gene activated in rat insulinomas.";
RL Diabetes 35:1178-1180(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1390896; DOI=10.1016/0167-4781(92)90020-z;
RA Takasawa S., Tohgo A., Unno M., Shiga K., Yonekura H., Okamoto H.;
RT "The primary structure of rat rig/ribosomal protein S15 gene.";
RL Biochim. Biophys. Acta 1132:228-230(1992).
RN [3]
RP PROTEIN SEQUENCE OF 2-145, CLEAVAGE OF INITIATOR METHIONINE, AND
RP ACETYLATION AT ALA-2.
RC STRAIN=Wistar; TISSUE=Liver;
RX PubMed=2044758; DOI=10.1016/0014-5793(91)80590-y;
RA Kitagawa M., Takasawa S., Kikuchi N., Itoh T., Teraoka H., Yamamoto H.,
RA Okamoto H.;
RT "Rig encodes ribosomal protein S15. The primary structure of mammalian
RT ribosomal protein S15.";
RL FEBS Lett. 283:210-214(1991).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS19 family.
CC {ECO:0000305}.
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DR EMBL; M19393; AAA42044.1; -; mRNA.
DR EMBL; D11388; BAA01984.1; -; Genomic_DNA.
DR PIR; S28939; R3RT15.
DR RefSeq; NP_058847.1; NM_017151.2.
DR AlphaFoldDB; P62845; -.
DR SMR; P62845; -.
DR BioGRID; 247955; 2.
DR IntAct; P62845; 10.
DR STRING; 10116.ENSRNOP00000035156; -.
DR iPTMnet; P62845; -.
DR PhosphoSitePlus; P62845; -.
DR jPOST; P62845; -.
DR PaxDb; P62845; -.
DR PRIDE; P62845; -.
DR Ensembl; ENSRNOT00000029791; ENSRNOP00000035156; ENSRNOG00000024603.
DR Ensembl; ENSRNOT00000113730; ENSRNOP00000092210; ENSRNOG00000024603.
DR GeneID; 29285; -.
DR KEGG; rno:29285; -.
DR UCSC; RGD:62026; rat.
DR CTD; 6209; -.
DR RGD; 62026; Rps15.
DR eggNOG; KOG0898; Eukaryota.
DR GeneTree; ENSGT00390000000475; -.
DR HOGENOM; CLU_097347_1_0_1; -.
DR InParanoid; P62845; -.
DR OMA; VIRTHCR; -.
DR OrthoDB; 1390881at2759; -.
DR PhylomeDB; P62845; -.
DR TreeFam; TF318650; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62845; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000024603; Expressed in thymus and 20 other tissues.
DR Genevisible; P62845; RN.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0005654; C:nucleoplasm; IDA:RGD.
DR GO; GO:0045202; C:synapse; IDA:SynGO.
DR GO; GO:0097371; F:MDM2/MDM4 family protein binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0003735; F:structural constituent of ribosome; IMP:RGD.
DR GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:RGD.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; ISO:RGD.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IMP:RGD.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:RGD.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; ISO:RGD.
DR GO; GO:0006412; P:translation; TAS:ProtInc.
DR Gene3D; 3.30.860.10; -; 1.
DR HAMAP; MF_00531; Ribosomal_S19; 1.
DR InterPro; IPR020934; Ribosomal_S15/S19_CS.
DR InterPro; IPR002222; Ribosomal_S19.
DR InterPro; IPR023575; Ribosomal_S19_S15_SF.
DR InterPro; IPR005713; Ribosomal_S19A/S15e.
DR PANTHER; PTHR11880; PTHR11880; 1.
DR Pfam; PF00203; Ribosomal_S19; 1.
DR PIRSF; PIRSF002144; Ribosomal_S19; 1.
DR PRINTS; PR00975; RIBOSOMALS19.
DR SUPFAM; SSF54570; SSF54570; 1.
DR TIGRFAMs; TIGR01025; uS19_arch; 1.
DR PROSITE; PS00323; RIBOSOMAL_S19; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Isopeptide bond;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2044758"
FT CHAIN 2..145
FT /note="40S ribosomal protein S15"
FT /id="PRO_0000130032"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:2044758"
FT CROSSLNK 108
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62841"
SQ SEQUENCE 145 AA; 17040 MW; CA2C682302C7B387 CRC64;
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL
RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS
ITYKPVKHGR PGIGATHSSR FIPLK
