B1OKA_NIDOK
ID B1OKA_NIDOK Reviewed; 22 AA.
AC C0HL08;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Brevinin-1OKa {ECO:0000303|PubMed:15629529};
OS Nidirana okinavana (Kampira Falls frog) (Babina okinavana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Nidirana.
OX NCBI_TaxID=156870 {ECO:0000303|PubMed:15629529};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT LYS-22.
RC TISSUE=Skin {ECO:0000303|PubMed:15629529};
RX PubMed=15629529; DOI=10.1016/j.peptides.2004.08.008;
RA Conlon J.M., Sonnevend A., Jouenne T., Coquet L., Cosquer D., Vaudry H.,
RA Iwamuro S.;
RT "A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown
RT frog Rana okinavana.";
RL Peptides 26:185-190(2005).
CC -!- FUNCTION: Antimicrobial peptide. Active against Gram-negative bacterium
CC E.coli (MIC=12.5 uM) and against Gram-positive bacterium S.aureus
CC (MIC=12.5 uM). {ECO:0000269|PubMed:15629529}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P86027}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:15629529}.
CC -!- MASS SPECTROMETRY: Mass=2290.4; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:15629529};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000303|PubMed:15629529}.
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DR AlphaFoldDB; C0HL08; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted.
FT PEPTIDE 1..22
FT /note="Brevinin-1OKa"
FT /evidence="ECO:0000269|PubMed:15629529"
FT /id="PRO_0000443437"
FT MOD_RES 22
FT /note="Lysine amide"
FT /evidence="ECO:0000269|PubMed:15629529"
SQ SEQUENCE 22 AA; 2292 MW; 3C8F33D1FCCE5C47 CRC64;
FFGSMIGALA KGLPSLISLI KK