ID   B1OKC_NIDOK             Reviewed;          22 AA.
AC   C0HL10;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2018, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Brevinin-1OKc {ECO:0000303|PubMed:15629529};
OS   Nidirana okinavana (Kampira Falls frog) (Babina okinavana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Nidirana.
OX   NCBI_TaxID=156870 {ECO:0000303|PubMed:15629529};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT LYS-22.
RC   TISSUE=Skin {ECO:0000303|PubMed:15629529};
RX   PubMed=15629529; DOI=10.1016/j.peptides.2004.08.008;
RA   Conlon J.M., Sonnevend A., Jouenne T., Coquet L., Cosquer D., Vaudry H.,
RA   Iwamuro S.;
RT   "A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown
RT   frog Rana okinavana.";
RL   Peptides 26:185-190(2005).
CC   -!- FUNCTION: Antimicrobial peptide. Active against Gram-negative bacterium
CC       E.coli (MIC=6 uM) and against Gram-positive bacterium S.aureus
CC       (MIC=12.5 uM). {ECO:0000269|PubMed:15629529}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P86027}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:15629529}.
CC   -!- MASS SPECTROMETRY: Mass=2272.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15629529};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000303|PubMed:15629529}.
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DR   AlphaFoldDB; C0HL10; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Brevinin-1OKc"
FT                   /evidence="ECO:0000269|PubMed:15629529"
FT                   /id="PRO_0000443439"
FT   MOD_RES         22
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:15629529"
SQ   SEQUENCE   22 AA;  2274 MW;  3C885E11FCCE5C47 CRC64;
     FFGSIIGALA KGLPSLISLI KK