ID   ABC1_ENCCU              Reviewed;         596 AA.
AC   Q8SQI5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable ABC transporter ECU01_0200/ECU01_1410;
GN   OrderedLocusNames=ECU01_0200;
GN   and
GN   OrderedLocusNames=ECU01_1410;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11157783; DOI=10.1101/gr.164301;
RA   Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M.,
RA   Weissenbach J., Saurin W., Vivares C.P.;
RT   "Sequence and analysis of chromosome I of the amitochondriate intracellular
RT   parasite Encephalitozoon cuniculi (Microspora).";
RL   Genome Res. 11:198-207(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC       Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC       Heavy Metal importer (TC 3.A.1.210) subfamily. {ECO:0000305}.
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DR   EMBL; AL391737; CAD24890.1; -; Genomic_DNA.
DR   EMBL; AL391737; CAD25014.1; -; Genomic_DNA.
DR   RefSeq; XP_965855.1; XM_960762.1.
DR   RefSeq; XP_965979.1; XM_960886.1.
DR   AlphaFoldDB; Q8SQI5; -.
DR   SMR; Q8SQI5; -.
DR   GeneID; 860194; -.
DR   GeneID; 860320; -.
DR   KEGG; ecu:ECU01_0200; -.
DR   KEGG; ecu:ECU01_1410; -.
DR   VEuPathDB; MicrosporidiaDB:ECU01_0200; -.
DR   VEuPathDB; MicrosporidiaDB:ECU01_1410; -.
DR   HOGENOM; CLU_000604_84_1_1; -.
DR   InParanoid; Q8SQI5; -.
DR   OMA; YASMWAS; -.
DR   OrthoDB; 248727at2759; -.
DR   Proteomes; UP000000819; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..596
FT                   /note="Probable ABC transporter ECU01_0200/ECU01_1410"
FT                   /id="PRO_0000093413"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          39..318
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          361..593
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         370
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         400..411
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   596 AA;  65559 MW;  53FC2622E0F11CD3 CRC64;
     MRRMDRWTVC RRLASMARPV SFLEAALMAV VAACIVLGKW FDVMSIKRRG LIINGLKDIK
     GMGSANVSSI YGDAAAFLVL RTLSSAFTES KAILFSAVTN RVVQASTSRI LDLTMHAAHS
     CEIKPTELNR IVERGNRKIS KVLVKTLTVA TPALFRLALL FREVHAMFGP KYLVPILFTA
     AAYAAYTCVM LRIRARYRKE INNADNSVSR RIHECVSNVD LVRACCSEQF EVSRLAGEME
     TMWALKLSDK GCVGMTNLGQ RALFSVLFVH VAFKGIADMA ALRMTVGDLS VLFSFVLSID
     ASMWTLGGIA RDLGFWLTDC TDLLCLHDGL ERAAEQGPGA GAAAEGMAAC PSSPPGEAAA
     VEFDDVSFAY PRSAAYPRSA HVLSGVSFRI MRGERVGIIG RPGSGKSTIL RLILMLHRHK
     GRIRVNGAEL WSASPRAVRG SIGCILQDGL LFDESILYNV MYGCPRAGFH RVLRECKNAG
     LSDVVRRKGL HSRMKALSGG EMQMVSLARC FLKDAPLMLL DEATSKLDAE TERDVFGLMM
     GMRGKTIVMV LHDLWMTEHL DRVILVDSGT VKEVGTHSEL MGLRGMYWRM KTASRE