RS17B_YEAST
ID RS17B_YEAST Reviewed; 136 AA.
AC P14127; D6VT72;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=40S ribosomal protein S17-B {ECO:0000303|PubMed:9559554};
DE AltName: Full=RP51B;
DE AltName: Full=Small ribosomal subunit protein eS17-B {ECO:0000303|PubMed:24524803};
GN Name=RPS17B {ECO:0000303|PubMed:9559554}; Synonyms=RP51B;
GN OrderedLocusNames=YDR447C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6092944; DOI=10.1128/mcb.4.9.1871-1879.1984;
RA Abovich N., Rosbash M.;
RT "Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement
RT and contribute to the ribosomes.";
RL Mol. Cell. Biol. 4:1871-1879(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NOMENCLATURE, AND SUBUNIT.
RX PubMed=9559554;
RX DOI=10.1002/(sici)1097-0061(19980330)14:5<471::aid-yea241>3.0.co;2-u;
RA Planta R.J., Mager W.H.;
RT "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.";
RL Yeast 14:471-477(1998).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=22096102; DOI=10.1126/science.1212642;
RA Ben-Shem A., Garreau de Loubresse N., Melnikov S., Jenner L., Yusupova G.,
RA Yusupov M.;
RT "The structure of the eukaryotic ribosome at 3.0 A resolution.";
RL Science 334:1524-1529(2011).
RN [8]
RP NOMENCLATURE.
RX PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
RA Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
RA Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
RA Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
RA Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
RA Williamson J.R., Wilson D., Yonath A., Yusupov M.;
RT "A new system for naming ribosomal proteins.";
RL Curr. Opin. Struct. Biol. 24:165-169(2014).
CC -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC responsible for the synthesis of proteins in the cell. The small
CC ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC molecules. The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC leave the ribosome through a tunnel in the LSU and interact with
CC protein factors that function in enzymatic processing, targeting, and
CC the membrane insertion of nascent chains at the exit of the ribosomal
CC tunnel. {ECO:0000305|PubMed:22096102}.
CC -!- SUBUNIT: Component of the small ribosomal subunit (SSU). Mature yeast
CC ribosomes consist of a small (40S) and a large (60S) subunit. The 40S
CC small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33
CC different proteins (encoded by 57 genes). The large 60S subunit
CC contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different
CC proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
CC {ECO:0000269|PubMed:22096102, ECO:0000305|PubMed:9559554}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:22096102}.
CC -!- MISCELLANEOUS: Present with 30500 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- MISCELLANEOUS: There are 2 genes for eS17 in yeast. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS17 family.
CC {ECO:0000305}.
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DR EMBL; K02480; AAA34991.1; -; Genomic_DNA.
DR EMBL; U33007; AAB64890.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12282.1; -; Genomic_DNA.
DR PIR; S20161; R4BY7B.
DR RefSeq; NP_010735.3; NM_001180755.3.
DR PDB; 5M1J; EM; 3.30 A; R2=2-126.
DR PDB; 5MC6; EM; 3.80 A; G=1-136.
DR PDB; 5MEI; X-ray; 3.50 A; S=2-126.
DR PDB; 5TBW; X-ray; 3.00 A; S=2-126.
DR PDB; 5TGA; X-ray; 3.30 A; C7/c7=2-126.
DR PDB; 6GQ1; EM; 4.40 A; AH=2-126.
DR PDB; 6GQB; EM; 3.90 A; AH=2-126.
DR PDB; 6GQV; EM; 4.00 A; AH=2-126.
DR PDB; 6SNT; EM; 2.80 A; R=1-136.
DR PDB; 6SV4; EM; 3.30 A; G/Gb/Gc=1-136.
DR PDB; 6T7I; EM; 3.20 A; SR=1-136.
DR PDB; 6T7T; EM; 3.10 A; SR=1-136.
DR PDB; 6T83; EM; 4.00 A; Rb/s=1-136.
DR PDB; 6TB3; EM; 2.80 A; G=2-126.
DR PDB; 6TNU; EM; 3.10 A; G=2-126.
DR PDB; 6WOO; EM; 2.90 A; RR=2-124.
DR PDB; 6XIQ; EM; 4.20 A; AH=1-136.
DR PDB; 6XIR; EM; 3.20 A; AH=1-136.
DR PDB; 7A1G; EM; 3.00 A; H=2-126.
DR PDB; 7B7D; EM; 3.30 A; G=2-126.
DR PDB; 7NRC; EM; 3.90 A; SG=2-126.
DR PDB; 7NRD; EM; 4.36 A; SG=2-126.
DR PDBsum; 5M1J; -.
DR PDBsum; 5MC6; -.
DR PDBsum; 5MEI; -.
DR PDBsum; 5TBW; -.
DR PDBsum; 5TGA; -.
DR PDBsum; 6GQ1; -.
DR PDBsum; 6GQB; -.
DR PDBsum; 6GQV; -.
DR PDBsum; 6SNT; -.
DR PDBsum; 6SV4; -.
DR PDBsum; 6T7I; -.
DR PDBsum; 6T7T; -.
DR PDBsum; 6T83; -.
DR PDBsum; 6TB3; -.
DR PDBsum; 6TNU; -.
DR PDBsum; 6WOO; -.
DR PDBsum; 6XIQ; -.
DR PDBsum; 6XIR; -.
DR PDBsum; 7A1G; -.
DR PDBsum; 7B7D; -.
DR PDBsum; 7NRC; -.
DR PDBsum; 7NRD; -.
DR AlphaFoldDB; P14127; -.
DR SMR; P14127; -.
DR BioGRID; 32502; 176.
DR IntAct; P14127; 64.
DR MINT; P14127; -.
DR STRING; 4932.YDR447C; -.
DR iPTMnet; P14127; -.
DR MaxQB; P14127; -.
DR PaxDb; P14127; -.
DR EnsemblFungi; YDR447C_mRNA; YDR447C; YDR447C.
DR GeneID; 852058; -.
DR KEGG; sce:YDR447C; -.
DR SGD; S000002855; RPS17B.
DR VEuPathDB; FungiDB:YDR447C; -.
DR eggNOG; KOG0187; Eukaryota.
DR GeneTree; ENSGT00390000006548; -.
DR HOGENOM; CLU_112958_0_1_1; -.
DR InParanoid; P14127; -.
DR OMA; CGRVRTK; -.
DR BioCyc; YEAST:G3O-29978-MON; -.
DR Reactome; R-SCE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SCE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SCE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-SCE-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-SCE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-SCE-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-SCE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SCE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SCE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P14127; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P14127; protein.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; NAS:SGD.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:SGD.
DR GO; GO:0002181; P:cytoplasmic translation; NAS:SGD.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IMP:SGD.
DR Gene3D; 1.10.60.20; -; 1.
DR HAMAP; MF_00511; Ribosomal_S17e; 1.
DR InterPro; IPR001210; Ribosomal_S17e.
DR InterPro; IPR018273; Ribosomal_S17e_CS.
DR InterPro; IPR036401; RPS17e-like_sf.
DR PANTHER; PTHR10732; PTHR10732; 1.
DR Pfam; PF00833; Ribosomal_S17e; 1.
DR SUPFAM; SSF116820; SSF116820; 1.
DR PROSITE; PS00712; RIBOSOMAL_S17E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..136
FT /note="40S ribosomal protein S17-B"
FT /id="PRO_0000141547"
FT HELIX 7..20
FT /evidence="ECO:0007829|PDB:7A1G"
FT TURN 21..23
FT /evidence="ECO:0007829|PDB:7A1G"
FT HELIX 28..38
FT /evidence="ECO:0007829|PDB:7A1G"
FT HELIX 44..62
FT /evidence="ECO:0007829|PDB:7A1G"
FT HELIX 72..80
FT /evidence="ECO:0007829|PDB:7A1G"
FT HELIX 104..113
FT /evidence="ECO:0007829|PDB:7A1G"
SQ SEQUENCE 136 AA; 15803 MW; 83EE5382870EA289 CRC64;
MGRVRTKTVK RASKALIERY YPKLTLDFQT NKRLCDEIAT IQSKRLRNKI AGYTTHLMKR
IQKGPVRGIS FKLQEEERER KDQYVPEVSA LDLSRSNGVL NVDNQTSDLV KSLGLKLPLS
VINVSAQRDR RYRKRN
