B2L13_HUMAN
ID B2L13_HUMAN Reviewed; 485 AA.
AC Q9BXK5; B3KPE7; Q96B37; Q96IB7; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Bcl-2-like protein 13;
DE Short=Bcl2-L-13;
DE AltName: Full=Bcl-rambo;
DE AltName: Full=Protein Mil1;
GN Name=BCL2L13; Synonyms=MIL1; ORFNames=CD003;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11262395; DOI=10.1074/jbc.m010520200;
RA Kataoka T., Holler N., Micheau O., Martinon F., Tinel A., Hofmann K.,
RA Tschopp J.;
RT "Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique
RT C-terminal extension.";
RL J. Biol. Chem. 276:19548-19554(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11381032; DOI=10.1101/gr.154901;
RA Footz T.K., Brinkman-Mills P., Banting G.S., Maier S.A., Riazi M.A.,
RA Bridgland L.J., Hu S., Birren B., Minoshima S., Shimizu N., Pan H.,
RA Nguyen T., Fang F., Fu Y., Ray L., Wu H., Shaull S., Phan S., Yao Z.,
RA Chen F., Huan A., Hu P., Wang Q., Loh P., Qi S., Roe B.A., McDermid H.E.;
RT "Analysis of the cat eye syndrome critical region in humans and the region
RT of conserved synteny in mice: a search for candidate genes at or near the
RT human chromosome 22 pericentromere.";
RL Genome Res. 11:1053-1070(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pheochromocytoma;
RA Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT "A novel gene expressed in human pheochromocytoma.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-360.
RC TISSUE=Eye, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 77-485 (ISOFORM 2).
RC TISSUE=Glial tumor;
RA Zemskova M.Y., Lilly M., Escher A.P.;
RT "Mil1, a novel human gene encoding mitochondria located protein promoting
RT cell survival.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-485 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; SER-420 AND SER-426,
RP VARIANT [LARGE SCALE ANALYSIS] ARG-46, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420; SER-426 AND SER-429, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420 AND SER-426, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303; SER-420; SER-426 AND
RP SER-444, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-261; SER-326 AND
RP SER-410, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May promote the activation of caspase-3 and apoptosis.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9BXK5; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-747430, EBI-10827839;
CC Q9BXK5; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-747430, EBI-11522760;
CC Q9BXK5; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-747430, EBI-11957045;
CC Q9BXK5; P05090: APOD; NbExp=3; IntAct=EBI-747430, EBI-715495;
CC Q9BXK5; P29972: AQP1; NbExp=3; IntAct=EBI-747430, EBI-745213;
CC Q9BXK5; Q53XK0: BET1; NbExp=3; IntAct=EBI-747430, EBI-10242927;
CC Q9BXK5; Q8WVX3-2: C4orf3; NbExp=5; IntAct=EBI-747430, EBI-12003442;
CC Q9BXK5; P19397: CD53; NbExp=3; IntAct=EBI-747430, EBI-6657396;
CC Q9BXK5; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-747430, EBI-12256978;
CC Q9BXK5; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-747430, EBI-17233035;
CC Q9BXK5; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-747430, EBI-10305240;
CC Q9BXK5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-747430, EBI-711490;
CC Q9BXK5; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-747430, EBI-10976398;
CC Q9BXK5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-747430, EBI-18938272;
CC Q9BXK5; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-747430, EBI-12175685;
CC Q9BXK5; O75084: FZD7; NbExp=3; IntAct=EBI-747430, EBI-746917;
CC Q9BXK5; P60520: GABARAPL2; NbExp=4; IntAct=EBI-747430, EBI-720116;
CC Q9BXK5; Q10471: GALNT2; NbExp=3; IntAct=EBI-747430, EBI-10226985;
CC Q9BXK5; P01350: GAST; NbExp=3; IntAct=EBI-747430, EBI-3436637;
CC Q9BXK5; P30519: HMOX2; NbExp=3; IntAct=EBI-747430, EBI-712096;
CC Q9BXK5; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-747430, EBI-10266796;
CC Q9BXK5; O60333-2: KIF1B; NbExp=3; IntAct=EBI-747430, EBI-10975473;
CC Q9BXK5; O43561-2: LAT; NbExp=3; IntAct=EBI-747430, EBI-8070286;
CC Q9BXK5; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-747430, EBI-12033434;
CC Q9BXK5; P21145: MAL; NbExp=5; IntAct=EBI-747430, EBI-3932027;
CC Q9BXK5; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-747430, EBI-10317425;
CC Q9BXK5; Q9Y342: PLLP; NbExp=3; IntAct=EBI-747430, EBI-3919291;
CC Q9BXK5; P26678: PLN; NbExp=8; IntAct=EBI-747430, EBI-692836;
CC Q9BXK5; P60201: PLP1; NbExp=3; IntAct=EBI-747430, EBI-8653150;
CC Q9BXK5; P60201-2: PLP1; NbExp=6; IntAct=EBI-747430, EBI-12188331;
CC Q9BXK5; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-747430, EBI-10485931;
CC Q9BXK5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-747430, EBI-10262251;
CC Q9BXK5; P78382: SLC35A1; NbExp=3; IntAct=EBI-747430, EBI-12870360;
CC Q9BXK5; Q96KT7: SLC35G5; NbExp=3; IntAct=EBI-747430, EBI-13598465;
CC Q9BXK5; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-747430, EBI-12188413;
CC Q9BXK5; Q08629: SPOCK1; NbExp=3; IntAct=EBI-747430, EBI-2682560;
CC Q9BXK5; Q86Y82: STX12; NbExp=3; IntAct=EBI-747430, EBI-2691717;
CC Q9BXK5; Q9UNK0: STX8; NbExp=3; IntAct=EBI-747430, EBI-727240;
CC Q9BXK5; Q9BZW4: TM6SF2; NbExp=3; IntAct=EBI-747430, EBI-13082040;
CC Q9BXK5; Q5BJH2: TMEM128; NbExp=3; IntAct=EBI-747430, EBI-10243515;
CC Q9BXK5; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-747430, EBI-2339195;
CC Q9BXK5; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-747430, EBI-10315004;
CC Q9BXK5; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-747430, EBI-11956809;
CC Q9BXK5; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-747430, EBI-726044;
CC Q9BXK5; A0PK05: TMEM72; NbExp=3; IntAct=EBI-747430, EBI-12878352;
CC Q9BXK5; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-747430, EBI-12015604;
CC Q9BXK5; Q8N661: TMEM86B; NbExp=6; IntAct=EBI-747430, EBI-2548832;
CC Q9BXK5; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-747430, EBI-12111910;
CC Q9BXK5; Q71RG4: TMUB2; NbExp=3; IntAct=EBI-747430, EBI-2820477;
CC Q9BXK5; P01375: TNF; NbExp=3; IntAct=EBI-747430, EBI-359977;
CC Q9BXK5; Q9H2S6-2: TNMD; NbExp=3; IntAct=EBI-747430, EBI-12003398;
CC Q9BXK5; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-747430, EBI-11988865;
CC Q9BXK5; Q15836: VAMP3; NbExp=3; IntAct=EBI-747430, EBI-722343;
CC Q9BXK5; O75379-2: VAMP4; NbExp=3; IntAct=EBI-747430, EBI-10187996;
CC Q9BXK5; O76024: WFS1; NbExp=3; IntAct=EBI-747430, EBI-720609;
CC Q9BXK5; B2R9H7; NbExp=3; IntAct=EBI-747430, EBI-10175711;
CC Q9BXK5; Q5ZSD5: sidF; Xeno; NbExp=7; IntAct=EBI-747430, EBI-15625247;
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=2;
CC IsoId=Q9BXK5-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9BXK5-2; Sequence=VSP_000526, VSP_000527;
CC Name=3;
CC IsoId=Q9BXK5-4; Sequence=VSP_046931;
CC -!- TISSUE SPECIFICITY: Ubiquitous, with the highest levels of expression
CC in heart, placenta and pancreas.
CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF03602.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAG09680.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF325209; AAK27358.1; -; mRNA.
DR EMBL; AF246665; AAK15150.1; -; mRNA.
DR EMBL; AF183411; AAG09680.1; ALT_FRAME; mRNA.
DR EMBL; CR456521; CAG30407.1; -; mRNA.
DR EMBL; AK056248; BAG51659.1; -; mRNA.
DR EMBL; AC006285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007658; AAH07658.1; -; mRNA.
DR EMBL; BC016037; AAH16037.1; -; mRNA.
DR EMBL; AF146568; AAF03602.1; ALT_INIT; mRNA.
DR EMBL; AL133029; CAB61361.1; -; mRNA.
DR CCDS; CCDS13746.1; -. [Q9BXK5-1]
DR CCDS; CCDS59448.1; -. [Q9BXK5-4]
DR CCDS; CCDS86995.1; -. [Q9BXK5-2]
DR PIR; T42703; T42703.
DR RefSeq; NP_001257658.1; NM_001270729.1. [Q9BXK5-4]
DR RefSeq; NP_001257659.1; NM_001270730.1. [Q9BXK5-4]
DR RefSeq; NP_001257660.1; NM_001270731.1. [Q9BXK5-4]
DR RefSeq; NP_056182.2; NM_015367.3. [Q9BXK5-1]
DR RefSeq; XP_011544423.1; XM_011546121.2. [Q9BXK5-1]
DR RefSeq; XP_016884217.1; XM_017028728.1. [Q9BXK5-4]
DR RefSeq; XP_016884218.1; XM_017028729.1. [Q9BXK5-4]
DR RefSeq; XP_016884219.1; XM_017028730.1. [Q9BXK5-4]
DR RefSeq; XP_016884220.1; XM_017028731.1. [Q9BXK5-4]
DR RefSeq; XP_016884221.1; XM_017028732.1. [Q9BXK5-4]
DR RefSeq; XP_016884222.1; XM_017028733.1.
DR AlphaFoldDB; Q9BXK5; -.
DR BioGRID; 117285; 104.
DR DIP; DIP-60895N; -.
DR IntAct; Q9BXK5; 93.
DR MINT; Q9BXK5; -.
DR STRING; 9606.ENSP00000480836; -.
DR GlyGen; Q9BXK5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BXK5; -.
DR PhosphoSitePlus; Q9BXK5; -.
DR SwissPalm; Q9BXK5; -.
DR BioMuta; BCL2L13; -.
DR DMDM; 23396740; -.
DR EPD; Q9BXK5; -.
DR jPOST; Q9BXK5; -.
DR MassIVE; Q9BXK5; -.
DR MaxQB; Q9BXK5; -.
DR PaxDb; Q9BXK5; -.
DR PeptideAtlas; Q9BXK5; -.
DR PRIDE; Q9BXK5; -.
DR ProteomicsDB; 3529; -.
DR ProteomicsDB; 79446; -. [Q9BXK5-1]
DR ProteomicsDB; 79447; -. [Q9BXK5-2]
DR Antibodypedia; 3673; 275 antibodies from 35 providers.
DR DNASU; 23786; -.
DR Ensembl; ENST00000317582.10; ENSP00000318883.5; ENSG00000099968.18. [Q9BXK5-1]
DR Ensembl; ENST00000399782.5; ENSP00000382682.1; ENSG00000099968.18. [Q9BXK5-2]
DR Ensembl; ENST00000418951.6; ENSP00000410019.3; ENSG00000099968.18. [Q9BXK5-4]
DR Ensembl; ENST00000493680.5; ENSP00000434764.1; ENSG00000099968.18. [Q9BXK5-2]
DR Ensembl; ENST00000543133.5; ENSP00000437667.1; ENSG00000099968.18. [Q9BXK5-4]
DR GeneID; 23786; -.
DR KEGG; hsa:23786; -.
DR MANE-Select; ENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2.
DR UCSC; uc002zmu.4; human. [Q9BXK5-1]
DR CTD; 23786; -.
DR DisGeNET; 23786; -.
DR GeneCards; BCL2L13; -.
DR HGNC; HGNC:17164; BCL2L13.
DR HPA; ENSG00000099968; Tissue enhanced (skeletal).
DR MIM; 619822; gene.
DR neXtProt; NX_Q9BXK5; -.
DR OpenTargets; ENSG00000099968; -.
DR PharmGKB; PA134912159; -.
DR VEuPathDB; HostDB:ENSG00000099968; -.
DR eggNOG; ENOG502R6AP; Eukaryota.
DR GeneTree; ENSGT00390000015552; -.
DR HOGENOM; CLU_032647_2_0_1; -.
DR InParanoid; Q9BXK5; -.
DR OMA; HDQISPP; -.
DR PhylomeDB; Q9BXK5; -.
DR TreeFam; TF330744; -.
DR PathwayCommons; Q9BXK5; -.
DR SignaLink; Q9BXK5; -.
DR BioGRID-ORCS; 23786; 17 hits in 1091 CRISPR screens.
DR ChiTaRS; BCL2L13; human.
DR GeneWiki; BCL2L13; -.
DR GenomeRNAi; 23786; -.
DR Pharos; Q9BXK5; Tbio.
DR PRO; PR:Q9BXK5; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BXK5; protein.
DR Bgee; ENSG00000099968; Expressed in secondary oocyte and 205 other tissues.
DR ExpressionAtlas; Q9BXK5; baseline and differential.
DR Genevisible; Q9BXK5; HS.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; NAS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; NAS:UniProtKB.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; NAS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR042398; BCL2L13.
DR PANTHER; PTHR15758; PTHR15758; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Membrane; Mitochondrion; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..485
FT /note="Bcl-2-like protein 13"
FT /id="PRO_0000143073"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 246..256
FT /note="A"
FT REPEAT 261..271
FT /note="A; approximate"
FT REPEAT 425..441
FT /note="B"
FT REPEAT 443..459
FT /note="B; approximate"
FT REGION 218..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 14..30
FT /note="BH4"
FT MOTIF 100..116
FT /note="BH3"
FT MOTIF 147..157
FT /note="BH1"
FT MOTIF 193..206
FT /note="BH2"
FT COMPBIAS 224..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 303
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 371
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P59017"
FT MOD_RES 375
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P59017"
FT MOD_RES 410
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 426
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 429
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 444
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..162
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046931"
FT VAR_SEQ 201
FT /note="G -> V (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:11381032,
FT ECO:0000303|PubMed:15461802, ECO:0000303|Ref.3"
FT /id="VSP_000526"
FT VAR_SEQ 202..485
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:11381032,
FT ECO:0000303|PubMed:15461802, ECO:0000303|Ref.3"
FT /id="VSP_000527"
FT VARIANT 46
FT /note="I -> R (in dbSNP:rs2587070)"
FT /evidence="ECO:0007744|PubMed:18669648"
FT /id="VAR_059141"
FT VARIANT 46
FT /note="I -> T (in dbSNP:rs2587070)"
FT /id="VAR_059142"
FT VARIANT 55
FT /note="I -> V (in dbSNP:rs16981016)"
FT /id="VAR_024377"
FT VARIANT 360
FT /note="P -> S (in dbSNP:rs9306198)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024378"
FT CONFLICT 170
FT /note="R -> L (in Ref. 8; AAF03602)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="E -> Q (in Ref. 9; CAB61361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 52723 MW; D9404665111B6CE0 CRC64;
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS LDQEILLKVK
TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM EDCLAHLGEK VSQELKEPLH
KALQMLLSQP VTYQAFRECT LETTVHASGW NKILVPLVLL RQMLLELTRR GQEPLSALLQ
FGVTYLEDYS AEYIIQQGGW GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES
PTVTTSWQSE SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN
NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT ATSLLGTREP
DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP ALEPTETLLS EKEINAREES
LVEELSPASE KKPVPPSEGK SRLSPAGEMK PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL
ALRKK
