ID   B2L14_BOVIN             Reviewed;         326 AA.
AC   Q5E9L4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Apoptosis facilitator Bcl-2-like protein 14;
DE            Short=Bcl2-L-14;
GN   Name=BCL2L14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Plays a role in apoptosis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by MELK, leading to inhibit its pro-apoptotic
CC       function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; BT020906; AAX08923.1; -; mRNA.
DR   RefSeq; NP_001015544.1; NM_001015544.1.
DR   AlphaFoldDB; Q5E9L4; -.
DR   STRING; 9913.ENSBTAP00000054020; -.
DR   PRIDE; Q5E9L4; -.
DR   GeneID; 508365; -.
DR   KEGG; bta:508365; -.
DR   CTD; 79370; -.
DR   eggNOG; KOG4728; Eukaryota.
DR   InParanoid; Q5E9L4; -.
DR   OrthoDB; 1288548at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR033229; BCL2L14.
DR   PANTHER; PTHR14965:SF1; PTHR14965:SF1; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Apoptosis facilitator Bcl-2-like protein 14"
FT                   /id="PRO_0000254026"
FT   REGION          100..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           211..225
FT                   /note="BH3"
FT   MOTIF           307..314
FT                   /note="BH2"
FT   COMPBIAS        133..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         44
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYK4"
SQ   SEQUENCE   326 AA;  36839 MW;  467E54BA7A0BEA33 CRC64;
     MCTASPCDLE EIPLDDEDSD SLEFKILEFY VKHHVFQNTS AILSPKHLRT RSLSQKGPER
     WPVSEAWTQG PWPCRHSQSS EKAINLTKKK SSWRTLFGVA EKEEDSQSSP PEICAQAQRS
     GVPQARPRSP KWPRSRSSMD QRLEHKAADP RVVSIANRVA EIVYSWPPPE EVHSQGGGFK
     SKGVLVFQGP QGQSGAESTK KEGEDQIIAR IVELLKYSGE QLERELKKDK VLMTCFQDVL
     SYSVVKTITD QFLRGVDTRG ESEVKAQSFK AALAIDVIAK LTTIDNHPMN RVLGFGTKYL
     KENFSPWIQQ HGGWEKILRM PHEEVD