B2L14_MOUSE
ID B2L14_MOUSE Reviewed; 328 AA.
AC Q9CPT0; Q3TVA7; Q8R141; Q9D3W3;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Apoptosis facilitator Bcl-2-like protein 14;
DE Short=Bcl2-L-14;
GN Name=Bcl2l14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, Stomach, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in apoptosis.
CC -!- INTERACTION:
CC Q9CPT0; P35545: Fau; NbExp=4; IntAct=EBI-8296066, EBI-309546;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by MELK, leading to inhibit its pro-apoptotic
CC function. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR EMBL; AK008682; BAB25830.1; -; mRNA.
DR EMBL; AK016670; BAB30370.1; -; mRNA.
DR EMBL; AK016997; BAB30545.1; -; mRNA.
DR EMBL; AK018579; BAB31290.1; -; mRNA.
DR EMBL; AK160247; BAE35712.1; -; mRNA.
DR EMBL; BC025541; AAH25541.1; -; mRNA.
DR CCDS; CCDS20636.1; -.
DR RefSeq; NP_080054.1; NM_025778.3.
DR RefSeq; XP_006506547.1; XM_006506484.3.
DR AlphaFoldDB; Q9CPT0; -.
DR BioGRID; 211735; 1.
DR IntAct; Q9CPT0; 1.
DR MINT; Q9CPT0; -.
DR STRING; 10090.ENSMUSP00000107591; -.
DR iPTMnet; Q9CPT0; -.
DR PhosphoSitePlus; Q9CPT0; -.
DR EPD; Q9CPT0; -.
DR MaxQB; Q9CPT0; -.
DR PaxDb; Q9CPT0; -.
DR PeptideAtlas; Q9CPT0; -.
DR PRIDE; Q9CPT0; -.
DR ProteomicsDB; 265186; -.
DR Antibodypedia; 11858; 295 antibodies from 35 providers.
DR Ensembl; ENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200.
DR Ensembl; ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200.
DR Ensembl; ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200.
DR GeneID; 66813; -.
DR KEGG; mmu:66813; -.
DR UCSC; uc009ekh.1; mouse.
DR CTD; 79370; -.
DR MGI; MGI:1914063; Bcl2l14.
DR VEuPathDB; HostDB:ENSMUSG00000030200; -.
DR eggNOG; KOG4728; Eukaryota.
DR GeneTree; ENSGT00940000154318; -.
DR HOGENOM; CLU_073095_0_0_1; -.
DR InParanoid; Q9CPT0; -.
DR OMA; AMCTTSA; -.
DR OrthoDB; 1288548at2759; -.
DR PhylomeDB; Q9CPT0; -.
DR TreeFam; TF336214; -.
DR BioGRID-ORCS; 66813; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9CPT0; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CPT0; protein.
DR Bgee; ENSMUSG00000030200; Expressed in seminiferous tubule of testis and 89 other tissues.
DR ExpressionAtlas; Q9CPT0; baseline and differential.
DR Genevisible; Q9CPT0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043229; C:intracellular organelle; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISO:MGI.
DR GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR033229; BCL2L14.
DR PANTHER; PTHR14965:SF1; PTHR14965:SF1; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..328
FT /note="Apoptosis facilitator Bcl-2-like protein 14"
FT /id="PRO_0000143076"
FT MOTIF 213..227
FT /note="BH3"
FT MOTIF 309..316
FT /note="BH2"
FT MOD_RES 44
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYK4"
FT CONFLICT 105
FT /note="L -> P (in Ref. 2; AAH25541)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="C -> F (in Ref. 1; BAB30545)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="Missing (in Ref. 2; AAH25541)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="R -> Q (in Ref. 2; AAH25541)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 36992 MW; FAC47379F008314C CRC64;
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKNTP AVFSPKLSRT RSLSQKALGT
WSTDSWTQVS LPCRGSPSSE KNISLGKKKS SWRTLFRVAE KEEGLPSSPK EIRAQGPQGP
FPVERQSGFH NQHWPRSLSS VEQRLESEVV DSKVACIANR VAEIVYSWPP PDVIHSQGGS
KLKERVSEIL YFRFEGPCDS KNKDGEDQII SKIVELLKFS GDQLGREIKK DKALMSSFQD
GLSYSTFKTI TDLFLRDVDT RGESEVKARG FKAALAIDAI AKLTAIDNHP MNRMLGFGTK
YLREYFSPWV QQNGGWEKIL GISHEEVD
