ID   B2L14_RAT               Reviewed;         326 AA.
AC   Q6AYK4;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Apoptosis facilitator Bcl-2-like protein 14;
DE            Short=Bcl2-L-14;
GN   Name=Bcl2l14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Plays a role in apoptosis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by MELK, leading to inhibit its pro-apoptotic
CC       function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; BC079010; AAH79010.1; -; mRNA.
DR   RefSeq; NP_001019509.1; NM_001024338.1.
DR   RefSeq; XP_006237595.1; XM_006237533.2.
DR   RefSeq; XP_006237596.1; XM_006237534.3.
DR   RefSeq; XP_008761638.1; XM_008763416.2.
DR   RefSeq; XP_017448325.1; XM_017592836.1.
DR   AlphaFoldDB; Q6AYK4; -.
DR   STRING; 10116.ENSRNOP00000029468; -.
DR   iPTMnet; Q6AYK4; -.
DR   PhosphoSitePlus; Q6AYK4; -.
DR   PaxDb; Q6AYK4; -.
DR   PRIDE; Q6AYK4; -.
DR   Ensembl; ENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632.
DR   GeneID; 500348; -.
DR   KEGG; rno:500348; -.
DR   UCSC; RGD:1562777; rat.
DR   CTD; 79370; -.
DR   RGD; 1562777; Bcl2l14.
DR   eggNOG; KOG4728; Eukaryota.
DR   GeneTree; ENSGT00940000154318; -.
DR   HOGENOM; CLU_073095_0_0_1; -.
DR   InParanoid; Q6AYK4; -.
DR   OMA; AMCTTSA; -.
DR   OrthoDB; 1288548at2759; -.
DR   PhylomeDB; Q6AYK4; -.
DR   TreeFam; TF336214; -.
DR   PRO; PR:Q6AYK4; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000028632; Expressed in testis and 13 other tissues.
DR   Genevisible; Q6AYK4; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043229; C:intracellular organelle; ISO:RGD.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0006915; P:apoptotic process; ISO:RGD.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
DR   GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR033229; BCL2L14.
DR   PANTHER; PTHR14965:SF1; PTHR14965:SF1; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Apoptosis facilitator Bcl-2-like protein 14"
FT                   /id="PRO_0000143077"
FT   REGION          99..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           211..225
FT                   /note="BH3"
FT   MOTIF           307..314
FT                   /note="BH2"
FT   MOD_RES         44
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   326 AA;  36891 MW;  EE4235D7A1EC27B8 CRC64;
     MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKSTP AVFSPKLSRT RSLSQKALGT
     WSTDSWTQIS LPCRDSLSSE KHISLGKKKS SWRTLFRVTE KEEEPPSSPK EIHAQGPFPV
     ERQGRNQHWS RSLSSVEQCL ESEAVDSKVA CIANRVAEIV YSWPPPDDSQ SQGGGKFKES
     VPKILHFELQ GPQLRPCDSK KDGEDQIINR IVELLKYSGD QLGREIKRDK ALVSIFQEGL
     SYSVFRTITD LFLRDVDTRG ESEIKAQGFK AALAIDAIAK LTAIDNHPMN RMLGFGTKYL
     REYFSPWVQQ NGGWEKILGL SHEEVD