B2L15_HUMAN
ID B2L15_HUMAN Reviewed; 163 AA.
AC Q5TBC7; A0PJY6; A8K074; I6LA82;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Bcl-2-like protein 15;
DE Short=Bcl2-L-15;
DE AltName: Full=Bcl-2 family kin;
DE Short=Bfk {ECO:0000303|PubMed:15961081};
GN Name=BCL2L15; Synonyms=C1orf178;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=15961081; DOI=10.1016/j.febslet.2005.05.050;
RA Dempsey C.E., Dive C., Fletcher D.J., Barnes F.A., Lobo A., Bingle C.D.,
RA Whyte M.K., Renshaw S.A.;
RT "Expression of pro-apoptotic Bfk isoforms reduces during malignant
RT transformation in the human gastrointestinal tract.";
RL FEBS Lett. 579:3646-3650(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-90.
RC TISSUE=Urinary bladder;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-90.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5TBC7; P50222: MEOX2; NbExp=3; IntAct=EBI-10247136, EBI-748397;
CC Q5TBC7; P26367: PAX6; NbExp=3; IntAct=EBI-10247136, EBI-747278;
CC Q5TBC7; P62487: POLR2G; NbExp=3; IntAct=EBI-10247136, EBI-347928;
CC Q5TBC7; Q04864-2: REL; NbExp=3; IntAct=EBI-10247136, EBI-10829018;
CC Q5TBC7; O00560: SDCBP; NbExp=3; IntAct=EBI-10247136, EBI-727004;
CC Q5TBC7; P15884-3: TCF4; NbExp=3; IntAct=EBI-10247136, EBI-13636688;
CC Q5TBC7; Q15562: TEAD2; NbExp=4; IntAct=EBI-10247136, EBI-6427252;
CC Q5TBC7; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10247136, EBI-11139477;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5TBC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5TBC7-2; Sequence=VSP_047627, VSP_047628;
CC -!- MISCELLANEOUS: [Isoform 2]: Pro-apoptotic when overexpressed.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/BCL2L15ID46259ch1p13.html";
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DR EMBL; AY265864; AAP93858.1; -; mRNA.
DR EMBL; AK289439; BAF82128.1; -; mRNA.
DR EMBL; AL137856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127719; AAI27720.1; -; mRNA.
DR EMBL; BC127720; AAI27721.1; -; mRNA.
DR CCDS; CCDS30809.1; -. [Q5TBC7-1]
DR RefSeq; NP_001010922.1; NM_001010922.2. [Q5TBC7-1]
DR PDB; 7CCL; X-ray; 2.70 A; A/B/C=1-163.
DR PDB; 7CCM; X-ray; 2.45 A; A/B/C=1-163.
DR PDBsum; 7CCL; -.
DR PDBsum; 7CCM; -.
DR AlphaFoldDB; Q5TBC7; -.
DR SMR; Q5TBC7; -.
DR BioGRID; 136727; 17.
DR IntAct; Q5TBC7; 10.
DR STRING; 9606.ENSP00000376992; -.
DR iPTMnet; Q5TBC7; -.
DR PhosphoSitePlus; Q5TBC7; -.
DR BioMuta; BCL2L15; -.
DR DMDM; 74745939; -.
DR jPOST; Q5TBC7; -.
DR MassIVE; Q5TBC7; -.
DR PaxDb; Q5TBC7; -.
DR PeptideAtlas; Q5TBC7; -.
DR PRIDE; Q5TBC7; -.
DR ProteomicsDB; 64897; -. [Q5TBC7-1]
DR Antibodypedia; 33849; 151 antibodies from 24 providers.
DR DNASU; 440603; -.
DR Ensembl; ENST00000393316.8; ENSP00000376992.3; ENSG00000188761.13. [Q5TBC7-1]
DR Ensembl; ENST00000393320.3; ENSP00000376995.3; ENSG00000188761.13. [Q5TBC7-2]
DR GeneID; 440603; -.
DR KEGG; hsa:440603; -.
DR MANE-Select; ENST00000393316.8; ENSP00000376992.3; NM_001010922.3; NP_001010922.1.
DR UCSC; uc001edw.4; human. [Q5TBC7-1]
DR CTD; 440603; -.
DR DisGeNET; 440603; -.
DR GeneCards; BCL2L15; -.
DR HGNC; HGNC:33624; BCL2L15.
DR HPA; ENSG00000188761; Tissue enhanced (intestine, stomach).
DR MIM; 619660; gene.
DR neXtProt; NX_Q5TBC7; -.
DR OpenTargets; ENSG00000188761; -.
DR PharmGKB; PA162377411; -.
DR VEuPathDB; HostDB:ENSG00000188761; -.
DR eggNOG; ENOG502SB5V; Eukaryota.
DR GeneTree; ENSGT00390000018096; -.
DR HOGENOM; CLU_1626530_0_0_1; -.
DR InParanoid; Q5TBC7; -.
DR OMA; SKTWCAQ; -.
DR PhylomeDB; Q5TBC7; -.
DR TreeFam; TF338066; -.
DR PathwayCommons; Q5TBC7; -.
DR SignaLink; Q5TBC7; -.
DR BioGRID-ORCS; 440603; 11 hits in 1072 CRISPR screens.
DR GenomeRNAi; 440603; -.
DR Pharos; Q5TBC7; Tbio.
DR PRO; PR:Q5TBC7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TBC7; protein.
DR Bgee; ENSG00000188761; Expressed in ileal mucosa and 120 other tissues.
DR ExpressionAtlas; Q5TBC7; baseline and differential.
DR Genevisible; Q5TBC7; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR033543; BCL2L15.
DR PANTHER; PTHR36466; PTHR36466; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Apoptosis; Reference proteome.
FT CHAIN 1..163
FT /note="Bcl-2-like protein 15"
FT /id="PRO_0000283003"
FT VAR_SEQ 44..56
FT /note="EPCSFDVAIIAGR -> KSGELKSWSYSRD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15961081"
FT /id="VSP_047627"
FT VAR_SEQ 57..163
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15961081"
FT /id="VSP_047628"
FT VARIANT 90
FT /note="D -> N (in dbSNP:rs1217381)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_031475"
FT HELIX 7..23
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 25..30
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 50..61
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 69..81
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 84..102
FT /evidence="ECO:0007829|PDB:7CCM"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:7CCL"
FT HELIX 108..126
FT /evidence="ECO:0007829|PDB:7CCM"
FT TURN 128..130
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 131..134
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 135..144
FT /evidence="ECO:0007829|PDB:7CCM"
FT HELIX 146..154
FT /evidence="ECO:0007829|PDB:7CCM"
FT TURN 158..160
FT /evidence="ECO:0007829|PDB:7CCM"
SQ SEQUENCE 163 AA; 17725 MW; 97BF05318C796856 CRC64;
MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV AIIAGRLRML
GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC AQDSSLAYER AFLAVSVKLL
EYMAHIAPEV VGQVAIPMTG MINGNQAIRE FIQGQGGWEN LES
