ID   B2LA1_BOVIN             Reviewed;         175 AA.
AC   Q3C2I0; Q08DT4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Bcl-2-related protein A1;
GN   Name=BCL2A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=16221993; DOI=10.1095/biolreprod.105.042655;
RA   Ushizawa K., Takahashi T., Kaneyama K., Hosoe M., Hashizume K.;
RT   "Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1,
RT   and its expression in trophoblastic binucleate cells of bovine placenta.";
RL   Biol. Reprod. 74:344-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal spinal cord;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Retards apoptosis induced by IL-3 deprivation. May function
CC       in the response of hemopoietic cells to external signals and in
CC       maintaining endothelial survival during infection (By similarity). Can
CC       inhibit apoptosis induced by serum starvation in the mammary epithelial
CC       cell line HC11 (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q07440}.
CC   -!- SUBUNIT: Interacts directly with BCL2L11/BIM, BAK1, BID, BMF and BBC3.
CC       Interacts directly with PMAIP1 (By similarity). Interacts with BOP (By
CC       similarity). Interacts with ING4 (By similarity). Interacts with UBQLN4
CC       (By similarity). {ECO:0000250|UniProtKB:Q07440,
CC       ECO:0000250|UniProtKB:Q16548}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16548}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; AB195549; BAE46584.1; -; mRNA.
DR   EMBL; BC123574; AAI23575.1; -; mRNA.
DR   RefSeq; NP_001032177.1; NM_001037100.3.
DR   RefSeq; XP_005221925.1; XM_005221868.2.
DR   AlphaFoldDB; Q3C2I0; -.
DR   SMR; Q3C2I0; -.
DR   STRING; 9913.ENSBTAP00000000977; -.
DR   PaxDb; Q3C2I0; -.
DR   PRIDE; Q3C2I0; -.
DR   Ensembl; ENSBTAT00000000977; ENSBTAP00000000977; ENSBTAG00000000735.
DR   GeneID; 282151; -.
DR   KEGG; bta:282151; -.
DR   CTD; 597; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000735; -.
DR   VGNC; VGNC:57345; BCL2A1.
DR   eggNOG; KOG4728; Eukaryota.
DR   GeneTree; ENSGT01050000244872; -.
DR   HOGENOM; CLU_1554763_0_0_1; -.
DR   InParanoid; Q3C2I0; -.
DR   OMA; IMDAFSF; -.
DR   OrthoDB; 1218929at2759; -.
DR   TreeFam; TF315834; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000000735; Expressed in mesenteric lymph node and 87 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR013282; Bcl2A1.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   PANTHER; PTHR11256:SF10; PTHR11256:SF10; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   PRINTS; PR01867; BCL2RLATEDA1.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..175
FT                   /note="Bcl-2-related protein A1"
FT                   /id="PRO_0000244412"
SQ   SEQUENCE   175 AA;  20045 MW;  0CF1AE37FC92FD9B CRC64;
     MTDTEFGYVH GLAEDYLKYV LQIQQPGSKP SKTSRVLQDV ASSVQDEVER TLKQCLDKFD
     VVSVDTARTI FNQVMEKEFE DGIVNWGRIV TIFAFEGILT KKLLGKCIAS DMDMCKDISF
     FVAEFITENT GEWIKQNGGW ENGFVKKFET KSGWLTFLEV TGKICETLCR LKQYY