ID   B2MG_CYPCA              Reviewed;         116 AA.
AC   Q03422;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=b2m;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8462991; DOI=10.1007/bf00216387;
RA   Dixon B., Stet R.J., van Erp S.H., Pohajdak B.;
RT   "Characterization of beta 2-microglobulin transcripts from two teleost
RT   species.";
RL   Immunogenetics 38:27-34(1993).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; L05536; AAA49203.1; -; mRNA.
DR   PIR; I50493; I50493.
DR   RefSeq; XP_018939097.1; XM_019083552.1.
DR   AlphaFoldDB; Q03422; -.
DR   SMR; Q03422; -.
DR   GeneID; 109066526; -.
DR   KEGG; ccar:109066526; -.
DR   OrthoDB; 1556447at2759; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..116
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018808"
FT   DOMAIN          24..110
FT                   /note="Ig-like C1-type"
FT   DISULFID        44..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   116 AA;  13309 MW;  44132FBA3DF6E0FC CRC64;
     MRAIITFALF CVLYVTVQGK TSSPKVQVYS HFPGEYGKEN TLICHVSGFH PPDITIELLK
     DGEILPNTQQ TDLAFEKGWQ FHLTKSVTFK PERGQNYACS VRHMNNKNIY SWEPNM