B2MG_EQUAS
ID B2MG_EQUAS Reviewed; 118 AA.
AC Q861S3;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2M;
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12557059; DOI=10.1007/s00251-002-0514-0;
RA Tallmadge R.L., Lear T.L., Johnson A.K., Guerin G., Millon L.V.,
RA Carpenter S.L., Antczak D.F.;
RT "Characterization of the beta(2)-microglobulin gene of the horse.";
RL Immunogenetics 54:725-733(2003).
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; AY124674; AAM77015.1; -; Genomic_DNA.
DR EMBL; AY124672; AAM77015.1; JOINED; Genomic_DNA.
DR EMBL; AY124673; AAM77015.1; JOINED; Genomic_DNA.
DR EMBL; AY124677; AAM77016.1; -; Genomic_DNA.
DR EMBL; AY124675; AAM77016.1; JOINED; Genomic_DNA.
DR EMBL; AY124676; AAM77016.1; JOINED; Genomic_DNA.
DR EMBL; AY124680; AAM77017.1; -; Genomic_DNA.
DR EMBL; AY124678; AAM77017.1; JOINED; Genomic_DNA.
DR EMBL; AY124679; AAM77017.1; JOINED; Genomic_DNA.
DR EMBL; AY124683; AAM77018.1; -; Genomic_DNA.
DR EMBL; AY124681; AAM77018.1; JOINED; Genomic_DNA.
DR EMBL; AY124682; AAM77018.1; JOINED; Genomic_DNA.
DR EMBL; AY124686; AAM77019.1; -; Genomic_DNA.
DR EMBL; AY124684; AAM77019.1; JOINED; Genomic_DNA.
DR EMBL; AY124685; AAM77019.1; JOINED; Genomic_DNA.
DR RefSeq; XP_014702559.1; XM_014847073.1.
DR RefSeq; XP_014702560.1; XM_014847074.1.
DR AlphaFoldDB; Q861S3; -.
DR SMR; Q861S3; -.
DR GeneID; 106835001; -.
DR KEGG; eai:106835001; -.
DR CTD; 567; -.
DR OMA; FHPPKID; -.
DR OrthoDB; 1556447at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..118
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000041820"
FT DOMAIN 25..111
FT /note="Ig-like C1-type"
FT DISULFID 45..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 118 AA; 13486 MW; 75AF34B0FC204F67 CRC64;
MARVVALVLL GLLSLTGLEA VQRIPKVQVY SRHPAENGKP NFLNCYVSGF HPPEIEIDLL
KNGEKMKVDR SDLSFSKDWS FYLLVHTDFT PNGVDEYSCR VQHSTLKEPL IVKWDRDL
