ID   B2MG_EQUQB              Reviewed;         118 AA.
AC   Q863B1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=B2M;
OS   Equus quagga burchellii (Plains zebra) (Equus burchelli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus; Equus quagga.
OX   NCBI_TaxID=89252;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12557059; DOI=10.1007/s00251-002-0514-0;
RA   Tallmadge R.L., Lear T.L., Johnson A.K., Guerin G., Millon L.V.,
RA   Carpenter S.L., Antczak D.F.;
RT   "Characterization of the beta(2)-microglobulin gene of the horse.";
RL   Immunogenetics 54:725-733(2003).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; AY124692; AAM77021.1; -; Genomic_DNA.
DR   EMBL; AY124690; AAM77021.1; JOINED; Genomic_DNA.
DR   EMBL; AY124691; AAM77021.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q863B1; -.
DR   SMR; Q863B1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05770; IgC_beta2m; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..118
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000041821"
FT   DOMAIN          25..111
FT                   /note="Ig-like C1-type"
FT   DISULFID        45..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   118 AA;  13486 MW;  75AF34B0FC204F67 CRC64;
     MARVVALVLL GLLSLTGLEA VQRIPKVQVY SRHPAENGKP NFLNCYVSGF HPPEIEIDLL
     KNGEKMKVDR SDLSFSKDWS FYLLVHTDFT PNGVDEYSCR VQHSTLKEPL IVKWDRDL