B2MG_FELCA
ID B2MG_FELCA Reviewed; 118 AA.
AC Q5MGS7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2M;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Coleman J.K., Yamamoto J.K.;
RT "Feline immunodeficiency virus specific tetramer construction and
RT analysis.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; AY829266; AAV88621.1; -; mRNA.
DR RefSeq; NP_001009876.1; NM_001009876.1.
DR PDB; 5XMF; X-ray; 2.10 A; B=21-118.
DR PDB; 5XMM; X-ray; 2.90 A; B=21-118.
DR PDBsum; 5XMF; -.
DR PDBsum; 5XMM; -.
DR AlphaFoldDB; Q5MGS7; -.
DR SMR; Q5MGS7; -.
DR STRING; 9685.ENSFCAP00000011347; -.
DR GeneID; 494145; -.
DR KEGG; fca:494145; -.
DR CTD; 567; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR InParanoid; Q5MGS7; -.
DR OrthoDB; 1556447at2759; -.
DR TreeFam; TF334167; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Immunity; Immunoglobulin domain; MHC I;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..118
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000041823"
FT DOMAIN 25..113
FT /note="Ig-like C1-type"
FT DISULFID 45..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:5XMF"
FT STRAND 41..53
FT /evidence="ECO:0007829|PDB:5XMF"
FT STRAND 56..61
FT /evidence="ECO:0007829|PDB:5XMF"
FT STRAND 81..89
FT /evidence="ECO:0007829|PDB:5XMF"
FT STRAND 97..102
FT /evidence="ECO:0007829|PDB:5XMF"
FT STRAND 110..113
FT /evidence="ECO:0007829|PDB:5XMF"
SQ SEQUENCE 118 AA; 13698 MW; 1C8E2AA6055EAA44 CRC64;
MARFVVLVLL GLLYLSHLDA VQHSPKVQVY SRHPAENGKP NFLNCYVSGF HPPQIDITLM
KNGKKMEAEQ TDLSFNRDWT FYLLVHTEFT PTVEDEYSCQ VNHTTLSEPK VVKWDRDM
