ID   B2MG_LABIN              Reviewed;         116 AA.
AC   P55076;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=b2m;
OS   Labeobarbus intermedius (Lake tana barbels) (Barbus intermedius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Torinae; Labeobarbus.
OX   NCBI_TaxID=40831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8824153; DOI=10.1007/bf02602803;
RA   Dixon B., Nagelkerke L.A., Sibbing F.A., Egberts E., Stet R.J.;
RT   "Evolution of MHC class II beta chain-encoding genes in the Lake Tana
RT   barbel species flock (Barbus intermedius complex).";
RL   Immunogenetics 44:419-431(1996).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; Z54151; CAA90865.1; -; mRNA.
DR   AlphaFoldDB; P55076; -.
DR   SMR; P55076; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..116
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018806"
FT   DOMAIN          24..111
FT                   /note="Ig-like C1-type"
FT   DISULFID        44..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   116 AA;  13224 MW;  3BD96DD681B524C0 CRC64;
     MRAIITFALF CVLYITVQAK TSSPKVQVYS HFPGEYGKEN TLICHVSGFH PPDITIELLR
     NGEILPNTQQ TDLAFEKGRQ FHLTKSVSFT PERGLDYACK VRHMSNTNAY SWEPNM