ID   B2MG_LEOFU              Reviewed;         119 AA.
AC   Q9TSX4;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=B2M;
OS   Leontocebus fuscicollis (Brown-mantled tamarin) (Saguinus fuscicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Leontocebus.
OX   NCBI_TaxID=9487;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10380996;
RX   DOI=10.1002/(sici)1098-2345(1999)48:3<225::aid-ajp4>3.0.co;2-4;
RA   Canavez F.C., Moreira M.A.M., Simon F., Parham P., Seuanez H.N.;
RT   "Phylogenetic relationships of the Callitrichinae (Platyrrhini, primates)
RT   based on beta2-microglobulin DNA sequences.";
RL   Am. J. Primatol. 48:225-236(1999).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; AF084633; AAF21793.1; -; Genomic_DNA.
DR   EMBL; AF084631; AAF21793.1; JOINED; Genomic_DNA.
DR   EMBL; AF084632; AAF21793.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q9TSX4; -.
DR   SMR; Q9TSX4; -.
DR   PRIDE; Q9TSX4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05770; IgC_beta2m; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..119
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018793"
FT   DOMAIN          25..114
FT                   /note="Ig-like C1-type"
FT   DISULFID        45..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   119 AA;  13835 MW;  5CEC4E7D46200FCA CRC64;
     MARFVVVALL VLLSVSDLEA IQHPPKIQVY SRYPADNGKP NFLNCYVSGF HPSDIEVDLL
     KNGKKIEKVE HSDLSFSKDW SFYLLYYTEF TPNEKDEYAC RVSHVTFLTP KTVKWDRNM