ID   B2MG_MESAU              Reviewed;          54 AA.
AC   P30442;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Fragment;
GN   Name=B2M;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=2339063; DOI=10.1093/nar/18.9.2789;
RA   Duguid J.R., Dinauer M.C.;
RT   "Library subtraction of in vitro cDNA libraries to identify differentially
RT   expressed genes in scrapie infection.";
RL   Nucleic Acids Res. 18:2789-2792(1990).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; X17002; CAA34865.1; -; mRNA.
DR   PIR; S15757; S15757.
DR   AlphaFoldDB; P30442; -.
DR   SMR; P30442; -.
DR   STRING; 10036.XP_005068588.1; -.
DR   eggNOG; ENOG502S8GM; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Immunoglobulin domain; MHC I; Reference proteome; Secreted.
FT   CHAIN           <1..54
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000080733"
FT   DOMAIN          3..41
FT                   /note="Ig-like C1-type"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   54 AA;  6448 MW;  F4C76635297A725C CRC64;
     MDKVELSDLS FNKDWSFYLL AHREFVPTAT DKYACRVSHI TLKEPKVVTW ERDM