B2MG_MOUSE
ID B2MG_MOUSE Reviewed; 119 AA.
AC P01887; Q91XJ8;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 222.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2m;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A).
RX PubMed=6354707; DOI=10.1002/j.1460-2075.1983.tb01546.x;
RA Daniel F., Morello D., le Bail O., Chambon P., Cayre Y., Kourilsky P.;
RT "Structure and expression of the mouse beta 2-microglobulin gene isolated
RT from somatic and non-expressing teratocarcinoma cells.";
RL EMBO J. 2:1061-1065(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE (ALLELE A).
RC STRAIN=BALB/cJ;
RX PubMed=6180834; DOI=10.1016/0092-8674(82)90182-9;
RA Parnes J.R., Seidman J.G.;
RT "Structure of wild-type and mutant mouse beta 2-microglobulin genes.";
RL Cell 29:661-669(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES W2; W3; W4 AND W5).
RC TISSUE=Liver;
RX PubMed=8482575; DOI=10.1007/bf00190898;
RA Hermel E., Robinson P.J., She J.-X., Lindahl K.F.;
RT "Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus
RT implies positive selection.";
RL Immunogenetics 38:106-116(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Lung, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 21-119 (ALLELES A AND B).
RC STRAIN=BALB/cJ, and C57BL/6J;
RX PubMed=6165997; DOI=10.1073/pnas.78.1.554;
RA Gates F.T. III, Coligan J.E., Kindt T.J.;
RT "Complete amino acid sequence of murine beta 2-microglobulin: structural
RT evidence for strain-related polymorphism.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:554-558(1981).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 31-57 AND 86-119 (ALLELE A).
RX PubMed=6166005; DOI=10.1073/pnas.78.4.2253;
RA Parnes J.R., Velan B., Felsenfeld A., Ramanathan L., Ferrini U.,
RA Appella E., Seidman J.G.;
RT "Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA
RT clones corresponding to rare mRNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:2253-2257(1981).
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3 (ALLELE A).
RX PubMed=3510743; DOI=10.1016/0092-8674(86)90760-9;
RA Kimura A., Israel A., le Bail O., Kourilsky P.;
RT "Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and
RT their role in the regulation of class I gene expression.";
RL Cell 44:261-272(1986).
RN [11]
RP PROTEIN SEQUENCE OF 21-60 (ALLELE A).
RX PubMed=59595; DOI=10.1016/0006-291x(76)91063-9;
RA Appella E., Tanigaki N., Natori T., Pressman D.;
RT "Partial amino acid sequence of mouse beta2-microglobulin.";
RL Biochem. Biophys. Res. Commun. 70:425-430(1976).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX PubMed=1323877; DOI=10.1126/science.1323877;
RA Fremont D.H., Matsumura M., Stura E.A., Peterson P.A., Wilson I.A.;
RT "Crystal structures of two viral peptides in complex with murine MHC class
RT I H-2Kb.";
RL Science 257:919-927(1992).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX PubMed=7506996; DOI=10.1016/0092-8674(94)90171-6;
RA Young A.C.M., Zhang W., Sacchettini J.C., Nathenson S.G.;
RT "The three-dimensional structure of H-2Db at 2.4-A resolution: implications
RT for antigen-determinant selection.";
RL Cell 76:39-50(1994).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX PubMed=9192660; DOI=10.1073/pnas.94.13.6880;
RA Balendiran G.K., Solheim J.C., Young A.C., Hansen T.H., Nathenson S.G.,
RA Sacchettini J.C.;
RT "The three-dimensional structure of an H-2Ld-peptide complex explains the
RT unique interaction of Ld with beta-2 microglobulin and peptide.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:6880-6885(1997).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX PubMed=9729040; DOI=10.1016/s1074-7613(00)80602-0;
RA Achour A., Persson K., Harris R.A., Sundbaeck J., Sentman C.L.,
RA Lindqvist Y., Schneider G., Kaerre K.;
RT "The crystal structure of H-2Dd MHC class I complexed with the HIV-1-
RT derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK
RT cell recognition.";
RL Immunity 9:199-208(1998).
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules. Forms a heterotrimer with MR1 and a metabolite
CC antigen. {ECO:0000250|UniProtKB:P61769}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- POLYMORPHISM: The following alleles of B2M are known: A, B, W2, W3, W4
CC and W5 (C). The sequence shown is that of allele B. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; X01838; CAA25970.1; -; mRNA.
DR EMBL; M12485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84363; AAA39667.1; -; Genomic_DNA.
DR EMBL; M84364; AAA39668.1; -; Genomic_DNA.
DR EMBL; M84365; AAA39669.1; -; Genomic_DNA.
DR EMBL; M84366; AAA39670.1; -; Genomic_DNA.
DR EMBL; M84367; AAA39671.1; -; Genomic_DNA.
DR EMBL; AK019389; BAB31695.1; -; mRNA.
DR EMBL; AK028378; BAC25917.1; -; mRNA.
DR EMBL; AK166067; BAE38551.1; -; mRNA.
DR EMBL; AL845457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL28084.1; -; Genomic_DNA.
DR EMBL; BC085164; AAH85164.1; -; mRNA.
DR EMBL; M10389; AAA39536.1; -; mRNA.
DR EMBL; M10416; AAA39537.1; -; mRNA.
DR CCDS; CCDS16654.1; -.
DR PIR; A90822; MGMSB2.
DR RefSeq; NP_033865.2; NM_009735.3.
DR PDB; 1BII; X-ray; 2.40 A; B=1-119.
DR PDB; 1BQH; X-ray; 2.80 A; B/E=21-119.
DR PDB; 1BZ9; X-ray; 2.80 A; B=21-119.
DR PDB; 1CD1; X-ray; 2.67 A; B/D=21-119.
DR PDB; 1DDH; X-ray; 3.10 A; B=22-119.
DR PDB; 1FFN; X-ray; 2.70 A; B/E=21-119.
DR PDB; 1FFO; X-ray; 2.65 A; B/E=21-119.
DR PDB; 1FFP; X-ray; 2.60 A; B/E=21-119.
DR PDB; 1FG2; X-ray; 2.75 A; B/E/H/K=21-119.
DR PDB; 1FO0; X-ray; 2.50 A; L=21-119.
DR PDB; 1FZJ; X-ray; 1.90 A; B=21-119.
DR PDB; 1FZK; X-ray; 1.70 A; B=21-119.
DR PDB; 1FZM; X-ray; 1.80 A; B=21-119.
DR PDB; 1FZO; X-ray; 1.80 A; B=21-119.
DR PDB; 1G6R; X-ray; 2.80 A; L/M=21-119.
DR PDB; 1G7P; X-ray; 1.50 A; B=21-119.
DR PDB; 1G7Q; X-ray; 1.60 A; B=21-119.
DR PDB; 1HOC; X-ray; 2.40 A; B=21-119.
DR PDB; 1INQ; X-ray; 2.20 A; B=21-119.
DR PDB; 1JPF; X-ray; 2.18 A; B=21-119.
DR PDB; 1JPG; X-ray; 2.20 A; B=21-119.
DR PDB; 1JUF; X-ray; 2.00 A; B=21-119.
DR PDB; 1K8D; X-ray; 2.30 A; B=21-119.
DR PDB; 1KBG; X-ray; 2.20 A; L=21-119.
DR PDB; 1KJ2; X-ray; 2.71 A; L/M=21-119.
DR PDB; 1KJ3; X-ray; 2.30 A; L/M=21-119.
DR PDB; 1KPU; X-ray; 1.50 A; B=21-119.
DR PDB; 1KPV; X-ray; 1.71 A; B=21-119.
DR PDB; 1LD9; X-ray; 2.40 A; B/E=21-119.
DR PDB; 1LDP; X-ray; 3.10 A; L=21-119.
DR PDB; 1LEG; X-ray; 1.75 A; B=21-119.
DR PDB; 1LEK; X-ray; 2.15 A; B=21-119.
DR PDB; 1LK2; X-ray; 1.35 A; B=21-119.
DR PDB; 1MHC; X-ray; 2.10 A; B/E=21-119.
DR PDB; 1MWA; X-ray; 2.40 A; L/M=21-119.
DR PDB; 1N3N; X-ray; 3.00 A; B/D/F/H=21-119.
DR PDB; 1N59; X-ray; 2.95 A; B/D=21-119.
DR PDB; 1N5A; X-ray; 2.85 A; B/E/H/K=21-119.
DR PDB; 1NAM; X-ray; 2.70 A; L=21-119.
DR PDB; 1NAN; X-ray; 2.30 A; I/P=21-119.
DR PDB; 1NEZ; X-ray; 2.10 A; B=21-119.
DR PDB; 1OSZ; X-ray; 2.10 A; B=21-119.
DR PDB; 1P1Z; X-ray; 3.26 A; B=21-119.
DR PDB; 1P4L; X-ray; 2.90 A; B=21-119.
DR PDB; 1PQZ; X-ray; 2.10 A; B=21-119.
DR PDB; 1QO3; X-ray; 2.30 A; B=21-119.
DR PDB; 1RJY; X-ray; 1.90 A; B/E=21-119.
DR PDB; 1RJZ; X-ray; 2.60 A; B/E=21-119.
DR PDB; 1RK0; X-ray; 2.61 A; B=21-119.
DR PDB; 1RK1; X-ray; 2.10 A; B=21-119.
DR PDB; 1S7Q; X-ray; 1.99 A; B=21-119.
DR PDB; 1S7R; X-ray; 2.95 A; B/E=21-119.
DR PDB; 1S7S; X-ray; 1.99 A; B=21-119.
DR PDB; 1S7T; X-ray; 2.30 A; B/E=21-119.
DR PDB; 1S7U; X-ray; 2.20 A; B/E/H/K=21-119.
DR PDB; 1S7V; X-ray; 2.20 A; B/E=21-119.
DR PDB; 1S7W; X-ray; 2.40 A; B/E/H/K=21-119.
DR PDB; 1S7X; X-ray; 2.41 A; B/E/H/K=21-119.
DR PDB; 1T0M; X-ray; 2.00 A; B/E=21-119.
DR PDB; 1T0N; X-ray; 1.80 A; B/E=21-119.
DR PDB; 1U58; X-ray; 1.90 A; B=21-119.
DR PDB; 1VAC; X-ray; 2.50 A; B=21-119.
DR PDB; 1VAD; X-ray; 2.50 A; B=21-119.
DR PDB; 1WBX; X-ray; 1.90 A; B=21-119.
DR PDB; 1WBY; X-ray; 2.30 A; B=21-119.
DR PDB; 1WBZ; X-ray; 2.00 A; B/D=21-119.
DR PDB; 1YN6; X-ray; 2.20 A; B=21-119.
DR PDB; 1YN7; X-ray; 2.20 A; B=21-119.
DR PDB; 1Z5L; X-ray; 2.20 A; B/D=21-119.
DR PDB; 1ZHB; X-ray; 2.70 A; B/E/H/K=21-119.
DR PDB; 1ZHN; X-ray; 2.80 A; B=21-119.
DR PDB; 1ZT1; X-ray; 2.50 A; B=21-119.
DR PDB; 1ZT7; X-ray; 3.00 A; B/D=21-119.
DR PDB; 2AKR; X-ray; 1.90 A; B/D=21-119.
DR PDB; 2CKB; X-ray; 3.00 A; L/M=21-119.
DR PDB; 2CLV; X-ray; 1.90 A; B/P=21-119.
DR PDB; 2CLZ; X-ray; 1.90 A; B/P=21-119.
DR PDB; 2FIK; X-ray; 1.80 A; B=21-119.
DR PDB; 2FO4; X-ray; 2.70 A; B=21-119.
DR PDB; 2FWO; X-ray; 2.60 A; B=21-119.
DR PDB; 2GAZ; X-ray; 2.61 A; B=21-119.
DR PDB; 2MHA; X-ray; 2.50 A; B/D=21-119.
DR PDB; 2OL3; X-ray; 2.90 A; L=21-119.
DR PDB; 2Q7Y; X-ray; 1.95 A; B/D=21-119.
DR PDB; 2QRI; X-ray; 2.00 A; A/B=21-119.
DR PDB; 2QRS; X-ray; 2.00 A; A/B=21-119.
DR PDB; 2QRT; X-ray; 1.80 A; A/B=21-119.
DR PDB; 2VAA; X-ray; 2.30 A; B=21-119.
DR PDB; 2VAB; X-ray; 2.50 A; B=21-119.
DR PDB; 2VE6; X-ray; 2.65 A; B/E/H/K=22-119.
DR PDB; 2ZOK; X-ray; 2.10 A; B/D/F/H=21-119.
DR PDB; 2ZOL; X-ray; 2.70 A; B/D=21-119.
DR PDB; 2ZSV; X-ray; 1.80 A; B/D=21-119.
DR PDB; 2ZSW; X-ray; 2.80 A; B/D/F/H=21-119.
DR PDB; 3ARB; X-ray; 2.70 A; B=21-119.
DR PDB; 3ARD; X-ray; 3.01 A; B=21-119.
DR PDB; 3ARE; X-ray; 2.80 A; B=21-119.
DR PDB; 3ARF; X-ray; 2.90 A; B=21-119.
DR PDB; 3ARG; X-ray; 3.00 A; B=21-119.
DR PDB; 3AU1; X-ray; 2.50 A; B=21-119.
DR PDB; 3BUY; X-ray; 2.60 A; B=21-119.
DR PDB; 3C8K; X-ray; 2.90 A; B=21-119.
DR PDB; 3CC5; X-ray; 1.91 A; B/E=21-119.
DR PDB; 3CCH; X-ray; 2.60 A; B/E/H/K=21-119.
DR PDB; 3CH1; X-ray; 2.30 A; B/E/H/K=21-119.
DR PDB; 3CPL; X-ray; 2.50 A; B/D=21-119.
DR PDB; 3CVH; X-ray; 2.90 A; B/N=21-119.
DR PDB; 3DMM; X-ray; 2.60 A; B=21-119.
DR PDB; 3E6F; X-ray; 2.41 A; B=22-119.
DR PDB; 3E6H; X-ray; 2.10 A; B=21-119.
DR PDB; 3ECB; X-ray; 1.70 A; B=21-119.
DR PDB; 3FOL; X-ray; 2.50 A; B=21-119.
DR PDB; 3FOM; X-ray; 2.10 A; B=21-119.
DR PDB; 3FON; X-ray; 2.03 A; B/D=21-119.
DR PDB; 3FTG; X-ray; 2.60 A; B=21-119.
DR PDB; 3G08; X-ray; 1.60 A; B=21-119.
DR PDB; 3GML; X-ray; 1.70 A; B=21-119.
DR PDB; 3GMM; X-ray; 1.80 A; B=21-119.
DR PDB; 3GMN; X-ray; 1.70 A; B=21-119.
DR PDB; 3GMO; X-ray; 1.60 A; B=21-119.
DR PDB; 3GMP; X-ray; 1.70 A; B=21-119.
DR PDB; 3GMQ; X-ray; 1.80 A; B=21-119.
DR PDB; 3GMR; X-ray; 1.90 A; B=21-119.
DR PDB; 3HE6; X-ray; 2.90 A; B=21-119.
DR PDB; 3HE7; X-ray; 2.80 A; B=21-119.
DR PDB; 3ILP; X-ray; 1.85 A; B=21-119.
DR PDB; 3ILQ; X-ray; 2.05 A; D=21-119.
DR PDB; 3L3H; X-ray; 2.70 A; B=21-119.
DR PDB; 3MA7; X-ray; 2.29 A; B/D=21-119.
DR PDB; 3NWM; X-ray; 2.70 A; A=21-119.
DR PDB; 3O8X; X-ray; 2.74 A; B=21-119.
DR PDB; 3O9W; X-ray; 2.80 A; B=21-119.
DR PDB; 3P4M; X-ray; 2.50 A; B/E=21-119.
DR PDB; 3P4N; X-ray; 2.50 A; B/E=21-119.
DR PDB; 3P4O; X-ray; 2.30 A; B/E=21-119.
DR PDB; 3P9L; X-ray; 2.00 A; B/E=21-119.
DR PDB; 3P9M; X-ray; 2.00 A; B/E=21-119.
DR PDB; 3PAB; X-ray; 2.20 A; B/E=21-119.
DR PDB; 3PQY; X-ray; 3.19 A; B/G/L/Q=21-119.
DR PDB; 3PWU; X-ray; 1.90 A; B=21-119.
DR PDB; 3QI9; X-ray; 2.30 A; B=21-119.
DR PDB; 3QUK; X-ray; 2.41 A; B/E=21-119.
DR PDB; 3QUL; X-ray; 2.00 A; B/E/H/K=21-119.
DR PDB; 3QUX; X-ray; 2.91 A; B=21-119.
DR PDB; 3QUY; X-ray; 2.25 A; B=21-119.
DR PDB; 3QUZ; X-ray; 2.30 A; B=21-119.
DR PDB; 3RGV; X-ray; 2.90 A; D=21-119.
DR PDB; 3ROL; X-ray; 2.60 A; B/D=21-119.
DR PDB; 3ROO; X-ray; 2.00 A; B/D=21-119.
DR PDB; 3RTQ; X-ray; 2.80 A; B=21-119.
DR PDB; 3RUG; X-ray; 2.20 A; B/D=21-119.
DR PDB; 3RZC; X-ray; 2.80 A; B=21-119.
DR PDB; 3SCM; X-ray; 2.50 A; B=21-119.
DR PDB; 3SDA; X-ray; 2.80 A; B=21-119.
DR PDB; 3SDC; X-ray; 3.10 A; B=21-119.
DR PDB; 3SDD; X-ray; 3.00 A; B=21-119.
DR PDB; 3T1F; X-ray; 1.70 A; B=21-119.
DR PDB; 3TA3; X-ray; 2.70 A; B=21-119.
DR PDB; 3TBS; X-ray; 2.49 A; B/E=21-119.
DR PDB; 3TBT; X-ray; 2.30 A; B/E/H/K=21-119.
DR PDB; 3TBV; X-ray; 2.10 A; B/D/F/H=21-119.
DR PDB; 3TBW; X-ray; 2.15 A; B/D/F/H=21-119.
DR PDB; 3TBY; X-ray; 2.50 A; B/E/H/K=21-119.
DR PDB; 3TN0; X-ray; 3.20 A; B=21-119.
DR PDB; 3TO4; X-ray; 3.10 A; B=21-119.
DR PDB; 3TVM; X-ray; 2.80 A; B/F=21-119.
DR PDB; 3UBX; X-ray; 3.10 A; B/E=21-119.
DR PDB; 3VJ6; X-ray; 1.90 A; B=21-119.
DR PDB; 3WS3; X-ray; 2.34 A; B/D=21-119.
DR PDB; 3WS6; X-ray; 1.98 A; C/D=21-119.
DR PDB; 4APQ; X-ray; 3.00 A; B=21-119.
DR PDB; 4EI5; X-ray; 3.10 A; B/F=21-119.
DR PDB; 4ELM; X-ray; 3.48 A; B/D=21-119.
DR PDB; 4HS3; X-ray; 2.10 A; B=21-119.
DR PDB; 4HUU; X-ray; 2.00 A; B/E=21-119.
DR PDB; 4HUV; X-ray; 2.50 A; B/E=21-119.
DR PDB; 4HUW; X-ray; 3.16 A; B/D/F/H=21-119.
DR PDB; 4HUX; X-ray; 2.20 A; B=21-119.
DR PDB; 4HV8; X-ray; 2.00 A; B/D=21-119.
DR PDB; 4IHO; X-ray; 2.80 A; B/E=21-119.
DR PDB; 4IRJ; X-ray; 3.00 A; B=21-119.
DR PDB; 4IRS; X-ray; 2.80 A; B=21-119.
DR PDB; 4L8B; X-ray; 2.20 A; B=21-119.
DR PDB; 4L8C; X-ray; 2.80 A; B/D/F/H=21-119.
DR PDB; 4L8D; X-ray; 1.90 A; B/D=21-119.
DR PDB; 4MNG; X-ray; 3.01 A; B/D=21-119.
DR PDB; 4MQ7; X-ray; 2.60 A; B=21-119.
DR PDB; 4MX7; X-ray; 2.24 A; B=21-119.
DR PDB; 4NSK; X-ray; 2.60 A; B=21-119.
DR PDB; 4PG2; X-ray; 2.80 A; C=21-119.
DR PDB; 4PG9; X-ray; 2.40 A; B=21-119.
DR PDB; 4PGB; X-ray; 2.80 A; B/E=21-119.
DR PDB; 4PGC; X-ray; 2.30 A; B/E=21-119.
DR PDB; 4PGD; X-ray; 2.70 A; B=21-119.
DR PDB; 4PGE; X-ray; 2.00 A; B=21-119.
DR PDB; 4PV8; X-ray; 2.31 A; B/D=21-119.
DR PDB; 4PV9; X-ray; 2.00 A; B/D=21-119.
DR PDB; 4Y16; X-ray; 2.60 A; B=21-119.
DR PDB; 4Y2D; X-ray; 3.05 A; B/F=21-119.
DR PDB; 4Y4F; X-ray; 3.19 A; B/F=21-119.
DR PDB; 4Y4H; X-ray; 3.10 A; B/F=21-119.
DR PDB; 4Y4K; X-ray; 2.90 A; B=21-119.
DR PDB; 4ZAK; X-ray; 2.82 A; B=21-119.
DR PDB; 4ZUS; X-ray; 2.60 A; B=21-119.
DR PDB; 4ZUT; X-ray; 2.60 A; B=21-119.
DR PDB; 4ZUU; X-ray; 2.20 A; B=21-119.
DR PDB; 4ZUV; X-ray; 2.30 A; B/E=21-119.
DR PDB; 4ZUW; X-ray; 2.60 A; B=21-119.
DR PDB; 5E8N; X-ray; 2.25 A; B/E/H/K=21-119.
DR PDB; 5E8O; X-ray; 1.98 A; B/E=21-119.
DR PDB; 5E8P; X-ray; 2.00 A; B/E=21-119.
DR PDB; 5EFI; X-ray; 1.80 A; B=21-119.
DR PDB; 5FKP; X-ray; 1.80 A; B=21-119.
DR PDB; 5IVX; X-ray; 2.10 A; B=21-119.
DR PDB; 5J6G; X-ray; 3.30 A; B/D=21-119.
DR PDB; 5J6H; X-ray; 2.30 A; B=21-119.
DR PDB; 5JWD; X-ray; 2.50 A; B=21-119.
DR PDB; 5JWE; X-ray; 2.40 A; B/D/F/H=21-119.
DR PDB; 5KD4; X-ray; 3.05 A; B/D=21-119.
DR PDB; 5KD7; X-ray; 2.35 A; B/D/G/J=21-119.
DR PDB; 5M00; X-ray; 1.95 A; B=21-119.
DR PDB; 5M02; X-ray; 1.75 A; B=21-119.
DR PDB; 5MZM; X-ray; 2.40 A; B/E=21-119.
DR PDB; 5OQF; X-ray; 2.27 A; A/B=21-119.
DR PDB; 5OQG; X-ray; 1.90 A; A/B=21-119.
DR PDB; 5OQH; X-ray; 2.05 A; A/B=21-109.
DR PDB; 5OQI; X-ray; 2.40 A; A/B=21-119.
DR PDB; 5SWS; X-ray; 2.86 A; B=21-119.
DR PDB; 5SWZ; X-ray; 2.65 A; B/G/L/Q=21-119.
DR PDB; 5T7G; X-ray; 1.96 A; B/D=21-119.
DR PDB; 5TIL; X-ray; 2.83 A; B/E=21-119.
DR PDB; 5TJE; X-ray; 3.20 A; B/D=21-119.
DR PDB; 5TW2; X-ray; 1.75 A; B=21-119.
DR PDB; 5TW5; X-ray; 1.85 A; B=21-117.
DR PDB; 5VCJ; X-ray; 3.16 A; B=21-119.
DR PDB; 5VCL; X-ray; 2.05 A; B=21-119.
DR PDB; 5WES; X-ray; 2.71 A; B=21-119.
DR PDB; 5WET; X-ray; 2.64 A; B=21-119.
DR PDB; 5WEU; X-ray; 1.58 A; B=21-119.
DR PDB; 5WLG; X-ray; 2.10 A; B/G=21-119.
DR PDB; 5WLI; X-ray; 2.20 A; B/E/H/K=21-119.
DR PDB; 6A97; X-ray; 2.15 A; B/D=21-119.
DR PDB; 6BMH; X-ray; 2.30 A; B/D/F/H=21-119.
DR PDB; 6BMK; X-ray; 2.43 A; B/D=21-119.
DR PDB; 6BNK; X-ray; 3.20 A; B/F=21-119.
DR PDB; 6BNL; X-ray; 2.60 A; B/F=21-119.
DR PDB; 6C5M; X-ray; 2.45 A; B=21-119.
DR PDB; 6C69; X-ray; 1.94 A; B=21-119.
DR PDB; 6C6A; X-ray; 2.45 A; B=21-119.
DR PDB; 6C6C; X-ray; 2.08 A; B=21-119.
DR PDB; 6C6E; X-ray; 2.18 A; B=21-119.
DR PDB; 6C6F; X-ray; 1.67 A; B=21-119.
DR PDB; 6C6H; X-ray; 2.00 A; B=21-119.
DR PDB; 6C6J; X-ray; 1.79 A; B=22-119.
DR PDB; 6CW6; X-ray; 2.85 A; B=21-119.
DR PDB; 6CW9; X-ray; 2.00 A; B=22-118.
DR PDB; 6CWB; X-ray; 2.85 A; B=21-119.
DR PDB; 6CWE; X-ray; 2.20 A; B=21-119.
DR PDB; 6CX5; X-ray; 2.40 A; B=21-119.
DR PDB; 6CX7; X-ray; 2.60 A; B=21-119.
DR PDB; 6CX9; X-ray; 2.36 A; B=21-119.
DR PDB; 6CXA; X-ray; 2.65 A; B=21-119.
DR PDB; 6CXE; X-ray; 2.05 A; B=21-119.
DR PDB; 6CXF; X-ray; 2.50 A; B=21-118.
DR PDB; 6CYW; X-ray; 1.95 A; B=21-119.
DR PDB; 6E1I; X-ray; 1.99 A; A=24-119.
DR PDB; 6G9Q; X-ray; 1.89 A; B=1-119.
DR PDB; 6G9R; X-ray; 2.70 A; B/D/F/H=21-119.
DR PDB; 6GB5; X-ray; 2.30 A; B/D=21-119.
DR PDB; 6GB6; X-ray; 1.78 A; B/E=21-119.
DR PDB; 6GB7; X-ray; 2.15 A; B/D/F/H=21-119.
DR PDB; 6H6D; X-ray; 2.40 A; B/E=21-119.
DR PDB; 6H6H; X-ray; 2.40 A; B/E=21-119.
DR PDB; 6I8C; X-ray; 1.92 A; A=21-119.
DR PDB; 6JQ2; X-ray; 2.40 A; B=21-119.
DR PDB; 6JQ3; X-ray; 2.50 A; B=21-119.
DR PDB; 6L9M; X-ray; 2.60 A; B/E/H/K=21-119.
DR PDB; 6L9N; X-ray; 2.60 A; B/E/H/K=21-119.
DR PDB; 6MIV; Other; 2.05 A; B=21-119.
DR PDB; 6MIY; X-ray; 2.75 A; B/F=21-119.
DR PDB; 6MJ4; X-ray; 2.00 A; B=21-119.
DR PDB; 6MJ6; X-ray; 2.45 A; B=21-119.
DR PDB; 6MJA; X-ray; 2.35 A; B=21-119.
DR PDB; 6MJI; X-ray; 2.30 A; B=21-119.
DR PDB; 6MJJ; X-ray; 1.93 A; B=21-119.
DR PDB; 6MJQ; X-ray; 3.00 A; B/F=21-119.
DR PDB; 6MP0; X-ray; 2.00 A; A=21-119.
DR PDB; 6MP1; X-ray; 2.21 A; A=21-119.
DR PDB; 6MSS; X-ray; 3.00 A; D=21-119.
DR PDB; 6OJP; X-ray; 2.17 A; B=21-119.
DR PDB; 6OMG; X-ray; 2.10 A; B=21-119.
DR PDB; 6OOR; X-ray; 2.45 A; B=21-119.
DR PDB; 6XNG; X-ray; 2.79 A; B=21-119.
DR PDB; 7JI2; X-ray; 1.95 A; B/E=21-119.
DR PDB; 7JWJ; X-ray; 3.25 A; B=1-119.
DR PDB; 7LFI; X-ray; 1.70 A; B/E=21-119.
DR PDB; 7LFJ; X-ray; 1.70 A; B/E=21-119.
DR PDB; 7LFK; X-ray; 1.60 A; B/E=21-119.
DR PDB; 7LFL; X-ray; 1.60 A; B=21-119.
DR PDB; 7LFM; X-ray; 1.60 A; B/E=21-119.
DR PDB; 7M72; X-ray; 2.40 A; B=21-119.
DR PDB; 7P0A; X-ray; 2.43 A; B/E=21-119.
DR PDB; 7P0T; X-ray; 2.60 A; B/E=21-119.
DR PDBsum; 1BII; -.
DR PDBsum; 1BQH; -.
DR PDBsum; 1BZ9; -.
DR PDBsum; 1CD1; -.
DR PDBsum; 1DDH; -.
DR PDBsum; 1FFN; -.
DR PDBsum; 1FFO; -.
DR PDBsum; 1FFP; -.
DR PDBsum; 1FG2; -.
DR PDBsum; 1FO0; -.
DR PDBsum; 1FZJ; -.
DR PDBsum; 1FZK; -.
DR PDBsum; 1FZM; -.
DR PDBsum; 1FZO; -.
DR PDBsum; 1G6R; -.
DR PDBsum; 1G7P; -.
DR PDBsum; 1G7Q; -.
DR PDBsum; 1HOC; -.
DR PDBsum; 1INQ; -.
DR PDBsum; 1JPF; -.
DR PDBsum; 1JPG; -.
DR PDBsum; 1JUF; -.
DR PDBsum; 1K8D; -.
DR PDBsum; 1KBG; -.
DR PDBsum; 1KJ2; -.
DR PDBsum; 1KJ3; -.
DR PDBsum; 1KPU; -.
DR PDBsum; 1KPV; -.
DR PDBsum; 1LD9; -.
DR PDBsum; 1LDP; -.
DR PDBsum; 1LEG; -.
DR PDBsum; 1LEK; -.
DR PDBsum; 1LK2; -.
DR PDBsum; 1MHC; -.
DR PDBsum; 1MWA; -.
DR PDBsum; 1N3N; -.
DR PDBsum; 1N59; -.
DR PDBsum; 1N5A; -.
DR PDBsum; 1NAM; -.
DR PDBsum; 1NAN; -.
DR PDBsum; 1NEZ; -.
DR PDBsum; 1OSZ; -.
DR PDBsum; 1P1Z; -.
DR PDBsum; 1P4L; -.
DR PDBsum; 1PQZ; -.
DR PDBsum; 1QO3; -.
DR PDBsum; 1RJY; -.
DR PDBsum; 1RJZ; -.
DR PDBsum; 1RK0; -.
DR PDBsum; 1RK1; -.
DR PDBsum; 1S7Q; -.
DR PDBsum; 1S7R; -.
DR PDBsum; 1S7S; -.
DR PDBsum; 1S7T; -.
DR PDBsum; 1S7U; -.
DR PDBsum; 1S7V; -.
DR PDBsum; 1S7W; -.
DR PDBsum; 1S7X; -.
DR PDBsum; 1T0M; -.
DR PDBsum; 1T0N; -.
DR PDBsum; 1U58; -.
DR PDBsum; 1VAC; -.
DR PDBsum; 1VAD; -.
DR PDBsum; 1WBX; -.
DR PDBsum; 1WBY; -.
DR PDBsum; 1WBZ; -.
DR PDBsum; 1YN6; -.
DR PDBsum; 1YN7; -.
DR PDBsum; 1Z5L; -.
DR PDBsum; 1ZHB; -.
DR PDBsum; 1ZHN; -.
DR PDBsum; 1ZT1; -.
DR PDBsum; 1ZT7; -.
DR PDBsum; 2AKR; -.
DR PDBsum; 2CKB; -.
DR PDBsum; 2CLV; -.
DR PDBsum; 2CLZ; -.
DR PDBsum; 2FIK; -.
DR PDBsum; 2FO4; -.
DR PDBsum; 2FWO; -.
DR PDBsum; 2GAZ; -.
DR PDBsum; 2MHA; -.
DR PDBsum; 2OL3; -.
DR PDBsum; 2Q7Y; -.
DR PDBsum; 2QRI; -.
DR PDBsum; 2QRS; -.
DR PDBsum; 2QRT; -.
DR PDBsum; 2VAA; -.
DR PDBsum; 2VAB; -.
DR PDBsum; 2VE6; -.
DR PDBsum; 2ZOK; -.
DR PDBsum; 2ZOL; -.
DR PDBsum; 2ZSV; -.
DR PDBsum; 2ZSW; -.
DR PDBsum; 3ARB; -.
DR PDBsum; 3ARD; -.
DR PDBsum; 3ARE; -.
DR PDBsum; 3ARF; -.
DR PDBsum; 3ARG; -.
DR PDBsum; 3AU1; -.
DR PDBsum; 3BUY; -.
DR PDBsum; 3C8K; -.
DR PDBsum; 3CC5; -.
DR PDBsum; 3CCH; -.
DR PDBsum; 3CH1; -.
DR PDBsum; 3CPL; -.
DR PDBsum; 3CVH; -.
DR PDBsum; 3DMM; -.
DR PDBsum; 3E6F; -.
DR PDBsum; 3E6H; -.
DR PDBsum; 3ECB; -.
DR PDBsum; 3FOL; -.
DR PDBsum; 3FOM; -.
DR PDBsum; 3FON; -.
DR PDBsum; 3FTG; -.
DR PDBsum; 3G08; -.
DR PDBsum; 3GML; -.
DR PDBsum; 3GMM; -.
DR PDBsum; 3GMN; -.
DR PDBsum; 3GMO; -.
DR PDBsum; 3GMP; -.
DR PDBsum; 3GMQ; -.
DR PDBsum; 3GMR; -.
DR PDBsum; 3HE6; -.
DR PDBsum; 3HE7; -.
DR PDBsum; 3ILP; -.
DR PDBsum; 3ILQ; -.
DR PDBsum; 3L3H; -.
DR PDBsum; 3MA7; -.
DR PDBsum; 3NWM; -.
DR PDBsum; 3O8X; -.
DR PDBsum; 3O9W; -.
DR PDBsum; 3P4M; -.
DR PDBsum; 3P4N; -.
DR PDBsum; 3P4O; -.
DR PDBsum; 3P9L; -.
DR PDBsum; 3P9M; -.
DR PDBsum; 3PAB; -.
DR PDBsum; 3PQY; -.
DR PDBsum; 3PWU; -.
DR PDBsum; 3QI9; -.
DR PDBsum; 3QUK; -.
DR PDBsum; 3QUL; -.
DR PDBsum; 3QUX; -.
DR PDBsum; 3QUY; -.
DR PDBsum; 3QUZ; -.
DR PDBsum; 3RGV; -.
DR PDBsum; 3ROL; -.
DR PDBsum; 3ROO; -.
DR PDBsum; 3RTQ; -.
DR PDBsum; 3RUG; -.
DR PDBsum; 3RZC; -.
DR PDBsum; 3SCM; -.
DR PDBsum; 3SDA; -.
DR PDBsum; 3SDC; -.
DR PDBsum; 3SDD; -.
DR PDBsum; 3T1F; -.
DR PDBsum; 3TA3; -.
DR PDBsum; 3TBS; -.
DR PDBsum; 3TBT; -.
DR PDBsum; 3TBV; -.
DR PDBsum; 3TBW; -.
DR PDBsum; 3TBY; -.
DR PDBsum; 3TN0; -.
DR PDBsum; 3TO4; -.
DR PDBsum; 3TVM; -.
DR PDBsum; 3UBX; -.
DR PDBsum; 3VJ6; -.
DR PDBsum; 3WS3; -.
DR PDBsum; 3WS6; -.
DR PDBsum; 4APQ; -.
DR PDBsum; 4EI5; -.
DR PDBsum; 4ELM; -.
DR PDBsum; 4HS3; -.
DR PDBsum; 4HUU; -.
DR PDBsum; 4HUV; -.
DR PDBsum; 4HUW; -.
DR PDBsum; 4HUX; -.
DR PDBsum; 4HV8; -.
DR PDBsum; 4IHO; -.
DR PDBsum; 4IRJ; -.
DR PDBsum; 4IRS; -.
DR PDBsum; 4L8B; -.
DR PDBsum; 4L8C; -.
DR PDBsum; 4L8D; -.
DR PDBsum; 4MNG; -.
DR PDBsum; 4MQ7; -.
DR PDBsum; 4MX7; -.
DR PDBsum; 4NSK; -.
DR PDBsum; 4PG2; -.
DR PDBsum; 4PG9; -.
DR PDBsum; 4PGB; -.
DR PDBsum; 4PGC; -.
DR PDBsum; 4PGD; -.
DR PDBsum; 4PGE; -.
DR PDBsum; 4PV8; -.
DR PDBsum; 4PV9; -.
DR PDBsum; 4Y16; -.
DR PDBsum; 4Y2D; -.
DR PDBsum; 4Y4F; -.
DR PDBsum; 4Y4H; -.
DR PDBsum; 4Y4K; -.
DR PDBsum; 4ZAK; -.
DR PDBsum; 4ZUS; -.
DR PDBsum; 4ZUT; -.
DR PDBsum; 4ZUU; -.
DR PDBsum; 4ZUV; -.
DR PDBsum; 4ZUW; -.
DR PDBsum; 5E8N; -.
DR PDBsum; 5E8O; -.
DR PDBsum; 5E8P; -.
DR PDBsum; 5EFI; -.
DR PDBsum; 5FKP; -.
DR PDBsum; 5IVX; -.
DR PDBsum; 5J6G; -.
DR PDBsum; 5J6H; -.
DR PDBsum; 5JWD; -.
DR PDBsum; 5JWE; -.
DR PDBsum; 5KD4; -.
DR PDBsum; 5KD7; -.
DR PDBsum; 5M00; -.
DR PDBsum; 5M02; -.
DR PDBsum; 5MZM; -.
DR PDBsum; 5OQF; -.
DR PDBsum; 5OQG; -.
DR PDBsum; 5OQH; -.
DR PDBsum; 5OQI; -.
DR PDBsum; 5SWS; -.
DR PDBsum; 5SWZ; -.
DR PDBsum; 5T7G; -.
DR PDBsum; 5TIL; -.
DR PDBsum; 5TJE; -.
DR PDBsum; 5TW2; -.
DR PDBsum; 5TW5; -.
DR PDBsum; 5VCJ; -.
DR PDBsum; 5VCL; -.
DR PDBsum; 5WES; -.
DR PDBsum; 5WET; -.
DR PDBsum; 5WEU; -.
DR PDBsum; 5WLG; -.
DR PDBsum; 5WLI; -.
DR PDBsum; 6A97; -.
DR PDBsum; 6BMH; -.
DR PDBsum; 6BMK; -.
DR PDBsum; 6BNK; -.
DR PDBsum; 6BNL; -.
DR PDBsum; 6C5M; -.
DR PDBsum; 6C69; -.
DR PDBsum; 6C6A; -.
DR PDBsum; 6C6C; -.
DR PDBsum; 6C6E; -.
DR PDBsum; 6C6F; -.
DR PDBsum; 6C6H; -.
DR PDBsum; 6C6J; -.
DR PDBsum; 6CW6; -.
DR PDBsum; 6CW9; -.
DR PDBsum; 6CWB; -.
DR PDBsum; 6CWE; -.
DR PDBsum; 6CX5; -.
DR PDBsum; 6CX7; -.
DR PDBsum; 6CX9; -.
DR PDBsum; 6CXA; -.
DR PDBsum; 6CXE; -.
DR PDBsum; 6CXF; -.
DR PDBsum; 6CYW; -.
DR PDBsum; 6E1I; -.
DR PDBsum; 6G9Q; -.
DR PDBsum; 6G9R; -.
DR PDBsum; 6GB5; -.
DR PDBsum; 6GB6; -.
DR PDBsum; 6GB7; -.
DR PDBsum; 6H6D; -.
DR PDBsum; 6H6H; -.
DR PDBsum; 6I8C; -.
DR PDBsum; 6JQ2; -.
DR PDBsum; 6JQ3; -.
DR PDBsum; 6L9M; -.
DR PDBsum; 6L9N; -.
DR PDBsum; 6MIV; -.
DR PDBsum; 6MIY; -.
DR PDBsum; 6MJ4; -.
DR PDBsum; 6MJ6; -.
DR PDBsum; 6MJA; -.
DR PDBsum; 6MJI; -.
DR PDBsum; 6MJJ; -.
DR PDBsum; 6MJQ; -.
DR PDBsum; 6MP0; -.
DR PDBsum; 6MP1; -.
DR PDBsum; 6MSS; -.
DR PDBsum; 6OJP; -.
DR PDBsum; 6OMG; -.
DR PDBsum; 6OOR; -.
DR PDBsum; 6XNG; -.
DR PDBsum; 7JI2; -.
DR PDBsum; 7JWJ; -.
DR PDBsum; 7LFI; -.
DR PDBsum; 7LFJ; -.
DR PDBsum; 7LFK; -.
DR PDBsum; 7LFL; -.
DR PDBsum; 7LFM; -.
DR PDBsum; 7M72; -.
DR PDBsum; 7P0A; -.
DR PDBsum; 7P0T; -.
DR AlphaFoldDB; P01887; -.
DR SMR; P01887; -.
DR BioGRID; 198291; 14.
DR DIP; DIP-6111N; -.
DR IntAct; P01887; 4.
DR MINT; P01887; -.
DR STRING; 10090.ENSMUSP00000099534; -.
DR iPTMnet; P01887; -.
DR PhosphoSitePlus; P01887; -.
DR SWISS-2DPAGE; P01887; -.
DR CPTAC; non-CPTAC-3965; -.
DR EPD; P01887; -.
DR jPOST; P01887; -.
DR PaxDb; P01887; -.
DR PeptideAtlas; P01887; -.
DR PRIDE; P01887; -.
DR ProteomicsDB; 277167; -.
DR Antibodypedia; 1913; 2469 antibodies from 48 providers.
DR DNASU; 12010; -.
DR Ensembl; ENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802.
DR GeneID; 12010; -.
DR KEGG; mmu:12010; -.
DR UCSC; uc008maf.1; mouse.
DR CTD; 567; -.
DR MGI; MGI:88127; B2m.
DR VEuPathDB; HostDB:ENSMUSG00000060802; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR GeneTree; ENSGT00690000102227; -.
DR HOGENOM; CLU_163066_0_0_1; -.
DR InParanoid; P01887; -.
DR OMA; FHPPKID; -.
DR OrthoDB; 1556447at2759; -.
DR PhylomeDB; P01887; -.
DR TreeFam; TF334167; -.
DR Reactome; R-MMU-1236974; ER-Phagosome pathway.
DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-2172127; DAP12 interactions.
DR Reactome; R-MMU-2424491; DAP12 signaling.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR BioGRID-ORCS; 12010; 18 hits in 83 CRISPR screens.
DR ChiTaRS; B2m; mouse.
DR EvolutionaryTrace; P01887; -.
DR PRO; PR:P01887; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P01887; protein.
DR Bgee; ENSMUSG00000060802; Expressed in seminal vesicle and 262 other tissues.
DR Genevisible; P01887; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:1990712; C:HFE-transferrin receptor complex; ISO:MGI.
DR GO; GO:0042824; C:MHC class I peptide loading complex; ISO:MGI.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:1990000; P:amyloid fibril formation; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; ISO:MGI.
DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; ISO:MGI.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IMP:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0006968; P:cellular defense response; TAS:MGI.
DR GO; GO:0071281; P:cellular response to iron ion; ISO:MGI.
DR GO; GO:0071283; P:cellular response to iron(III) ion; IMP:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
DR GO; GO:0071316; P:cellular response to nicotine; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0055072; P:iron ion homeostasis; IMP:MGI.
DR GO; GO:0006826; P:iron ion transport; IMP:MGI.
DR GO; GO:0007611; P:learning or memory; IMP:ARUK-UCL.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
DR GO; GO:2000978; P:negative regulation of forebrain neuron differentiation; IMP:ARUK-UCL.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IMP:ARUK-UCL.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IGI:MGI.
DR GO; GO:1900121; P:negative regulation of receptor binding; ISO:MGI.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:2000774; P:positive regulation of cellular senescence; ISO:MGI.
DR GO; GO:1904434; P:positive regulation of ferrous iron binding; ISO:MGI.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
DR GO; GO:1900122; P:positive regulation of receptor binding; ISO:MGI.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISO:MGI.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; ISO:MGI.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI.
DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; ISO:MGI.
DR GO; GO:0051289; P:protein homotetramerization; ISO:MGI.
DR GO; GO:0042026; P:protein refolding; IDA:MGI.
DR GO; GO:0045646; P:regulation of erythrocyte differentiation; IMP:MGI.
DR GO; GO:0034756; P:regulation of iron ion transport; ISO:MGI.
DR GO; GO:0003254; P:regulation of membrane depolarization; ISO:MGI.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IMP:MGI.
DR GO; GO:0007608; P:sensory perception of smell; IMP:ARUK-UCL.
DR GO; GO:0033077; P:T cell differentiation in thymus; IGI:MGI.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; IMP:MGI.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond; Immunity;
KW Immunoglobulin domain; MHC I; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:59595,
FT ECO:0000269|PubMed:6165997"
FT CHAIN 21..119
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000018784"
FT DOMAIN 25..114
FT /note="Ig-like C1-type"
FT DISULFID 45..100
FT VARIANT 8
FT /note="V -> I (in allele W3)"
FT /evidence="ECO:0000269|PubMed:8482575"
FT VARIANT 54
FT /note="H -> Q (in allele W4)"
FT /evidence="ECO:0000269|PubMed:8482575"
FT VARIANT 64
FT /note="K -> E (in allele W3)"
FT /evidence="ECO:0000269|PubMed:8482575"
FT VARIANT 101
FT /note="R -> T (in allele W2)"
FT /evidence="ECO:0000269|PubMed:8482575"
FT VARIANT 105
FT /note="A -> D (in allele A)"
FT /evidence="ECO:0000269|PubMed:3510743,
FT ECO:0000269|PubMed:59595, ECO:0000269|PubMed:6165997,
FT ECO:0000269|PubMed:6166005, ECO:0000269|PubMed:6180834,
FT ECO:0000269|PubMed:6354707"
FT VARIANT 105
FT /note="A -> V (in allele W2, W4 and W5)"
FT /evidence="ECO:0000269|PubMed:8482575"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:1BII"
FT STRAND 41..53
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 56..61
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:5JWD"
FT STRAND 70..76
FT /evidence="ECO:0007829|PDB:1LK2"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:2MHA"
FT STRAND 82..90
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 94..96
FT /evidence="ECO:0007829|PDB:1S7V"
FT STRAND 98..103
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:1LK2"
FT STRAND 111..114
FT /evidence="ECO:0007829|PDB:1LK2"
SQ SEQUENCE 119 AA; 13779 MW; 94F649EBCF1D7A4E CRC64;
MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF HPPHIEIQML
KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC RVKHASMAEP KTVYWDRDM
