ID   B2MG_ORENI              Reviewed;          37 AA.
AC   Q03423;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Fragment;
GN   Name=b2m;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8462991; DOI=10.1007/bf00216387;
RA   Dixon B., Stet R.J., van Erp S.H., Pohajdak B.;
RT   "Characterization of beta 2-microglobulin transcripts from two teleost
RT   species.";
RL   Immunogenetics 38:27-34(1993).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; L05537; AAA49436.1; -; mRNA.
DR   PIR; I51085; I51085.
DR   AlphaFoldDB; Q03423; -.
DR   SMR; Q03423; -.
DR   STRING; 8128.ENSONIP00000017819; -.
DR   eggNOG; ENOG502S8GM; Eukaryota.
DR   InParanoid; Q03423; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Immunoglobulin domain; MHC I; Reference proteome; Secreted.
FT   CHAIN           <1..>37
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000080739"
FT   DOMAIN          11..>37
FT                   /note="Ig-like C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
FT   NON_TER         37
SQ   SEQUENCE   37 AA;  4307 MW;  AABC5F01ED35736D CRC64;
     QVYWRHPGEY GKEDVLICHV SNFHPPDITI TLLKNGE