B2MG_ORNAN
ID B2MG_ORNAN Reviewed; 118 AA.
AC Q864T7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2M;
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12590975; DOI=10.1016/s0145-305x(02)00095-2;
RA Miska K.B., Hellman L., Miller R.D.;
RT "Characterization of beta(2)-microglobulin coding sequence from three non-
RT placental mammals: the duckbill platypus, the short-beaked echidna, and the
RT grey short-tailed opossum.";
RL Dev. Comp. Immunol. 27:247-256(2003).
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; AY125948; AAM98337.1; -; mRNA.
DR RefSeq; NP_001121090.1; NM_001127618.2.
DR RefSeq; XP_007659874.1; XM_007661684.1.
DR AlphaFoldDB; Q864T7; -.
DR SMR; Q864T7; -.
DR STRING; 9258.ENSOANP00000002450; -.
DR Ensembl; ENSOANT00000002451; ENSOANP00000002450; ENSOANG00000001539.
DR GeneID; 791104; -.
DR KEGG; oaa:791104; -.
DR CTD; 567; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR InParanoid; Q864T7; -.
DR OMA; FHPPKID; -.
DR OrthoDB; 1556447at2759; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000001539; Expressed in ovary and 7 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..118
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000041827"
FT DOMAIN 26..113
FT /note="Ig-like C1-type"
FT DISULFID 46..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 118 AA; 13329 MW; 777A34280C74F2DE CRC64;
MGSRWGIAVL GLFCFVSCLE AITSSPKIQV YSRHPAQIGE SNNLNCYVSS FHPPQISIRL
LKNGQEMPGV EMSDLSFSND WTFHRLVHTV FTPSNQDTFE CEVVHEGVKK TVKWEPDN
