B2MG_PANTR
ID B2MG_PANTR Reviewed; 119 AA.
AC P61770; P01884; Q9UDF4;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2M;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1690682; DOI=10.1111/j.1600-065x.1990.tb00040.x;
RA Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT "Comparison of class I MHC alleles in humans and apes.";
RL Immunol. Rev. 113:147-185(1990).
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules. Forms a heterotrimer with MR1 and a metabolite
CC antigen. {ECO:0000250|UniProtKB:P61769}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; M30683; AAA87972.1; -; mRNA.
DR PIR; I36963; I36963.
DR RefSeq; NP_001009066.1; NM_001009066.2.
DR AlphaFoldDB; P61770; -.
DR BMRB; P61770; -.
DR SMR; P61770; -.
DR STRING; 9598.ENSPTRP00000011997; -.
DR PaxDb; P61770; -.
DR GeneID; 450170; -.
DR KEGG; ptr:450170; -.
DR CTD; 567; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR HOGENOM; CLU_163066_0_0_1; -.
DR InParanoid; P61770; -.
DR OrthoDB; 1556447at2759; -.
DR TreeFam; TF334167; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..119
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000018785"
FT DOMAIN 25..113
FT /note="Ig-like C1-type"
FT DISULFID 45..100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 119 AA; 13715 MW; AFD2DBEF07DCEF27 CRC64;
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL
KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM
