B2MG_PIG
ID B2MG_PIG Reviewed; 118 AA.
AC Q07717; Q8WN08;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Beta-2-microglobulin;
DE AltName: Full=Lactollin;
DE Flags: Precursor;
GN Name=B2M;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8406623; DOI=10.1007/bf00184532;
RA Milland J., Loveland B.E., McKenzie I.F.C.;
RT "Isolation of a clone for pig beta 2-microglobulin cDNA.";
RL Immunogenetics 38:464-464(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RA Keene C.D., Ni H.-T., Low W.C.;
RT "Sus scrofa beta-2-microglobulin (B2M) gene.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; L13854; AAA16252.1; -; mRNA.
DR EMBL; F14868; CAA23304.1; -; mRNA.
DR EMBL; AF452448; AAL48289.1; -; Genomic_DNA.
DR PIR; I46609; I46609.
DR RefSeq; NP_999143.1; NM_213978.1.
DR RefSeq; XP_013848513.1; XM_013993059.1.
DR RefSeq; XP_013848514.1; XM_013993060.1.
DR PDB; 3QQ3; X-ray; 2.59 A; B/E=21-118.
DR PDB; 3QQ4; X-ray; 2.10 A; B=21-118.
DR PDB; 5H94; X-ray; 1.48 A; B/E=21-118.
DR PDB; 5NPZ; X-ray; 1.43 A; B=21-118.
DR PDB; 5NQ0; X-ray; 1.10 A; B=21-118.
DR PDB; 5NQ2; X-ray; 1.54 A; B=21-118.
DR PDB; 5YLX; X-ray; 2.20 A; B=21-118.
DR PDB; 6A6H; X-ray; 2.31 A; B=21-118.
DR PDB; 6KWK; X-ray; 2.50 A; B=21-118.
DR PDB; 6KWL; X-ray; 1.80 A; B=21-118.
DR PDB; 6KWN; X-ray; 2.40 A; B=21-118.
DR PDB; 6KWO; X-ray; 1.80 A; B=22-118.
DR PDB; 6LF8; X-ray; 2.50 A; B=22-118.
DR PDB; 6LF9; X-ray; 2.50 A; B/E/H/K=22-118.
DR PDB; 7EM9; X-ray; 1.90 A; B=21-118.
DR PDB; 7EMA; X-ray; 1.80 A; B=21-118.
DR PDB; 7EMB; X-ray; 1.97 A; B=21-118.
DR PDB; 7EMC; X-ray; 1.90 A; B/E/H=21-118.
DR PDB; 7EMD; X-ray; 1.70 A; B=21-118.
DR PDBsum; 3QQ3; -.
DR PDBsum; 3QQ4; -.
DR PDBsum; 5H94; -.
DR PDBsum; 5NPZ; -.
DR PDBsum; 5NQ0; -.
DR PDBsum; 5NQ2; -.
DR PDBsum; 5YLX; -.
DR PDBsum; 6A6H; -.
DR PDBsum; 6KWK; -.
DR PDBsum; 6KWL; -.
DR PDBsum; 6KWN; -.
DR PDBsum; 6KWO; -.
DR PDBsum; 6LF8; -.
DR PDBsum; 6LF9; -.
DR PDBsum; 7EM9; -.
DR PDBsum; 7EMA; -.
DR PDBsum; 7EMB; -.
DR PDBsum; 7EMC; -.
DR PDBsum; 7EMD; -.
DR AlphaFoldDB; Q07717; -.
DR SMR; Q07717; -.
DR STRING; 9823.ENSSSCP00000005044; -.
DR PaxDb; Q07717; -.
DR PeptideAtlas; Q07717; -.
DR PRIDE; Q07717; -.
DR Ensembl; ENSSSCT00000047804; ENSSSCP00000033396; ENSSSCG00000004687.
DR Ensembl; ENSSSCT00000061969; ENSSSCP00000052369; ENSSSCG00000004687.
DR Ensembl; ENSSSCT00000084189; ENSSSCP00000063329; ENSSSCG00000004687.
DR Ensembl; ENSSSCT00005043116; ENSSSCP00005026422; ENSSSCG00005027136.
DR Ensembl; ENSSSCT00005043138; ENSSSCP00005026440; ENSSSCG00005027136.
DR Ensembl; ENSSSCT00005043141; ENSSSCP00005026443; ENSSSCG00005027136.
DR Ensembl; ENSSSCT00015109665; ENSSSCP00015046677; ENSSSCG00015080622.
DR Ensembl; ENSSSCT00050104689; ENSSSCP00050045963; ENSSSCG00050076230.
DR Ensembl; ENSSSCT00065072733; ENSSSCP00065031692; ENSSSCG00065053119.
DR GeneID; 397033; -.
DR KEGG; ssc:397033; -.
DR CTD; 567; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR GeneTree; ENSGT00690000102227; -.
DR HOGENOM; CLU_163066_0_0_1; -.
DR InParanoid; Q07717; -.
DR OMA; ICHASGF; -.
DR OrthoDB; 1556447at2759; -.
DR TreeFam; TF334167; -.
DR Reactome; R-SSC-1236974; ER-Phagosome pathway.
DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway.
DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-SSC-2172127; DAP12 interactions.
DR Reactome; R-SSC-2424491; DAP12 signaling.
DR Reactome; R-SSC-6798695; Neutrophil degranulation.
DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR Proteomes; UP000008227; Chromosome 1.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000004687; Expressed in blood and 42 other tissues.
DR ExpressionAtlas; Q07717; baseline and differential.
DR Genevisible; Q07717; SS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Immunity; Immunoglobulin domain; MHC I;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..118
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000018787"
FT DOMAIN 25..112
FT /note="Ig-like C1-type"
FT DISULFID 45..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 70
FT /note="Q -> S (in Ref. 2; CAA23304)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="V -> A (in Ref. 3; AAL48289)"
FT /evidence="ECO:0000305"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:5NQ0"
FT STRAND 41..53
FT /evidence="ECO:0007829|PDB:5NQ0"
FT STRAND 56..61
FT /evidence="ECO:0007829|PDB:5NQ0"
FT STRAND 81..89
FT /evidence="ECO:0007829|PDB:5NQ0"
FT STRAND 97..102
FT /evidence="ECO:0007829|PDB:5NQ0"
FT STRAND 110..113
FT /evidence="ECO:0007829|PDB:5NQ0"
SQ SEQUENCE 118 AA; 13362 MW; 81FE20183B22D449 CRC64;
MAPLVALVLL GLLSLSGLDA VARPPKVQVY SRHPAENGKP NYLNCYVSGF HPPQIEIDLL
KNGEKMNAEQ SDLSFSKDWS FYLLVHTEFT PNAVDQYSCR VKHVTLDKPK IVKWDRDH
