ID   B2MG_PONPY              Reviewed;         119 AA.
AC   P16213; Q5R832;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=B2M;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1690682; DOI=10.1111/j.1600-065x.1990.tb00040.x;
RA   Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT   "Comparison of class I MHC alleles in humans and apes.";
RL   Immunol. Rev. 113:147-185(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules. Forms a heterotrimer with MR1 and a metabolite
CC       antigen. {ECO:0000250|UniProtKB:P61769}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; M30682; AAA88837.1; -; mRNA.
DR   EMBL; CR859923; CAH92078.1; -; mRNA.
DR   PIR; I61868; I61868.
DR   AlphaFoldDB; P16213; -.
DR   BMRB; P16213; -.
DR   SMR; P16213; -.
DR   PRIDE; P16213; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05770; IgC_beta2m; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..119
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018789"
FT   DOMAIN          25..113
FT                   /note="Ig-like C1-type"
FT   DISULFID        45..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   CONFLICT        31
FT                   /note="S -> T (in Ref. 1; AAA88837)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64..65
FT                   /note="ER -> VK (in Ref. 1; AAA88837)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        112
FT                   /note="I -> T (in Ref. 1; AAA88837)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   119 AA;  13715 MW;  AFD2DBEF07DCEF27 CRC64;
     MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL
     KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM