B2MG_RABIT
ID B2MG_RABIT Reviewed; 99 AA.
AC P01885;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Beta-2-microglobulin;
GN Name=B2M;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=87220; DOI=10.1021/bi00578a021;
RA Gates F.T. III, Coligan J.E., Kindt T.J.;
RT "Complete amino acid sequence of rabbit beta 2-microglobulin.";
RL Biochemistry 18:2267-2272(1979).
RN [2]
RP PROTEIN SEQUENCE OF 1-35.
RX PubMed=46618; DOI=10.1126/science.46618;
RA Cunningham B.A., Berggard I.;
RT "Partial amino acid sequence of rabbit beta2-microglobulin.";
RL Science 187:1079-1080(1975).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 1-30.
RX PubMed=3264885; DOI=10.1016/0161-5890(88)90134-4;
RA Wang C.R., Chen G.H., Newkirk M., Capra J.D., Mandy W.J.;
RT "Biochemical properties of a novel rabbit thymocyte specific class I-like
RT antigen.";
RL Mol. Immunol. 25:945-952(1988).
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR PIR; A02180; MGRBB2.
DR AlphaFoldDB; P01885; -.
DR SMR; P01885; -.
DR STRING; 9986.ENSOCUP00000014707; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR InParanoid; P01885; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd05770; IgC_beta2m; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Immunity; Immunoglobulin domain;
KW MHC I; Reference proteome; Secreted.
FT CHAIN 1..99
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000080737"
FT DOMAIN 5..92
FT /note="Ig-like C1-type"
FT DISULFID 25..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 20
FT /note="P -> D (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 33..34
FT /note="PQ -> SD (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 99 AA; 11654 MW; 61CF9A6C1ABBA0AC CRC64;
VQRAPNVQVY SRHPAENGKP NFLNCYVSGF HPPQIDIELL KNGVKIENVE QSDLSFNKDW
SFYLLVHTEF TPNNKNEYSC RVKHVTLKEP MTVKWDRDY
