RS18_BACSU
ID RS18_BACSU Reviewed; 79 AA.
AC P21475;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=30S ribosomal protein S18;
DE AltName: Full=BS21;
GN Name=rpsR; OrderedLocusNames=BSU40890;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA Ogasawara N., Nakai S., Yoshikawa H.;
RT "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT chromosome containing the replication origin.";
RL DNA Res. 1:1-14(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP PROTEIN SEQUENCE OF 2-24.
RX PubMed=6806564; DOI=10.1007/bf00330792;
RA Higo K., Otaka E., Osawa S.;
RT "Purification and characterization of 30S ribosomal proteins from Bacillus
RT subtilis: correlation to Escherichia coli 30S proteins.";
RL Mol. Gen. Genet. 185:239-244(1982).
RN [4]
RP INDUCTION.
RC STRAIN=168;
RX PubMed=14762004; DOI=10.1128/jb.186.4.1097-1105.2004;
RA Lindner C., Nijland R., van Hartskamp M., Bron S., Hamoen L.W.,
RA Kuipers O.P.;
RT "Differential expression of two paralogous genes of Bacillus subtilis
RT encoding single-stranded DNA binding protein.";
RL J. Bacteriol. 186:1097-1105(2004).
RN [5] {ECO:0007744|PDB:6HA1, ECO:0007744|PDB:6HA8}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 1-79 WITH AND WITHOUT
RP VIRGINIAMYCIN M, AND SUBUNIT.
RX PubMed=30126986; DOI=10.1073/pnas.1808535115;
RA Crowe-McAuliffe C., Graf M., Huter P., Takada H., Abdelshahid M.,
RA Novacek J., Murina V., Atkinson G.C., Hauryliuk V., Wilson D.N.;
RT "Structural basis for antibiotic resistance mediated by the Bacillus
RT subtilis ABCF ATPase VmlR.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:8978-8983(2018).
CC -!- FUNCTION: Binds as a heterodimer with protein S6 to the central domain
CC of the 16S rRNA, where it helps stabilize the platform of the 30S
CC subunit. {ECO:0000250}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit (PubMed:30126986). Forms a
CC tight heterodimer with protein S6 (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:30126986}.
CC -!- INDUCTION: Strongly expressed during exponential growth, decreases 2-4-
CC fold in stationary phase, part of the rpsF-ssbA-rpsR operon
CC (PubMed:14762004). The operon is induced by DNA damage by mitomycin C
CC (PubMed:14762004). {ECO:0000269|PubMed:14762004}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS18 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA05219.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D26185; BAA05219.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB16126.2; -; Genomic_DNA.
DR PIR; S66013; S66013.
DR RefSeq; NP_391969.2; NC_000964.3.
DR RefSeq; WP_003219224.1; NZ_JNCM01000034.1.
DR PDB; 3J9W; EM; 3.90 A; AR=1-79.
DR PDB; 5NJT; EM; 3.80 A; R=9-79.
DR PDB; 6HA1; EM; 3.10 A; r=1-79.
DR PDB; 6HA8; EM; 3.50 A; r=1-79.
DR PDB; 6HTQ; EM; 4.50 A; r=14-77.
DR PDB; 7O5B; EM; 3.33 A; R=1-79.
DR PDB; 7QV1; EM; 3.50 A; r=1-79.
DR PDB; 7QV2; EM; 3.50 A; r=1-79.
DR PDB; 7QV3; EM; 5.14 A; r=1-79.
DR PDBsum; 3J9W; -.
DR PDBsum; 5NJT; -.
DR PDBsum; 6HA1; -.
DR PDBsum; 6HA8; -.
DR PDBsum; 6HTQ; -.
DR PDBsum; 7O5B; -.
DR PDBsum; 7QV1; -.
DR PDBsum; 7QV2; -.
DR PDBsum; 7QV3; -.
DR AlphaFoldDB; P21475; -.
DR SMR; P21475; -.
DR STRING; 224308.BSU40890; -.
DR jPOST; P21475; -.
DR PaxDb; P21475; -.
DR PRIDE; P21475; -.
DR EnsemblBacteria; CAB16126; CAB16126; BSU_40890.
DR GeneID; 64305875; -.
DR GeneID; 937906; -.
DR KEGG; bsu:BSU40890; -.
DR PATRIC; fig|224308.179.peg.4430; -.
DR eggNOG; COG0238; Bacteria.
DR InParanoid; P21475; -.
DR OMA; QKKYCRF; -.
DR PhylomeDB; P21475; -.
DR BioCyc; BSUB:BSU40890-MON; -.
DR PRO; PR:P21475; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 4.10.640.10; -; 1.
DR HAMAP; MF_00270; Ribosomal_S18; 1.
DR InterPro; IPR001648; Ribosomal_S18.
DR InterPro; IPR018275; Ribosomal_S18_CS.
DR InterPro; IPR036870; Ribosomal_S18_sf.
DR PANTHER; PTHR13479; PTHR13479; 1.
DR Pfam; PF01084; Ribosomal_S18; 1.
DR PRINTS; PR00974; RIBOSOMALS18.
DR SUPFAM; SSF46911; SSF46911; 1.
DR TIGRFAMs; TIGR00165; S18; 1.
DR PROSITE; PS00057; RIBOSOMAL_S18; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:6806564"
FT CHAIN 2..79
FT /note="30S ribosomal protein S18"
FT /id="PRO_0000111117"
SQ SEQUENCE 79 AA; 8970 MW; 3DBF536109C61094 CRC64;
MAGGRRGGRA KRRKVCYFTS NGITHIDYKD VDLLKKFVSE RGKILPRRVT GTNAKYQRKL
TAAIKRARQM ALLPYVSGE
