RS18_CANLF
ID RS18_CANLF Reviewed; 152 AA.
AC Q5TJE9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=40S ribosomal protein S18;
GN Name=RPS18;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15607421; DOI=10.1016/j.ygeno.2004.09.009;
RA Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A.,
RA Ollier W.E.R., Binns M.M.;
RT "Genomic sequence of the class II region of the canine MHC: comparison with
RT the MHC of other mammalian species.";
RL Genomics 85:48-59(2005).
CC -!- FUNCTION: Located at the top of the head of the 40S subunit, it
CC contacts several helices of the 18S rRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS13 family.
CC {ECO:0000305}.
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DR EMBL; AJ630366; CAI11439.1; -; Genomic_DNA.
DR RefSeq; NP_001041547.1; NM_001048082.1.
DR PDB; 4V5Z; EM; 8.70 A; m=1-152.
DR PDBsum; 4V5Z; -.
DR AlphaFoldDB; Q5TJE9; -.
DR SMR; Q5TJE9; -.
DR STRING; 9612.ENSCAFP00000001357; -.
DR PaxDb; Q5TJE9; -.
DR PRIDE; Q5TJE9; -.
DR Ensembl; ENSCAFT00030024505; ENSCAFP00030021390; ENSCAFG00030013216.
DR Ensembl; ENSCAFT00030024575; ENSCAFP00030021460; ENSCAFG00030013216.
DR Ensembl; ENSCAFT00040038692; ENSCAFP00040033750; ENSCAFG00040020851.
DR Ensembl; ENSCAFT00040038732; ENSCAFP00040033785; ENSCAFG00040020851.
DR Ensembl; ENSCAFT00845036787; ENSCAFP00845028802; ENSCAFG00845020845.
DR Ensembl; ENSCAFT00845036893; ENSCAFP00845028884; ENSCAFG00845020845.
DR GeneID; 403685; -.
DR KEGG; cfa:403685; -.
DR CTD; 6222; -.
DR VEuPathDB; HostDB:ENSCAFG00845020845; -.
DR eggNOG; KOG3311; Eukaryota.
DR GeneTree; ENSGT00390000012691; -.
DR HOGENOM; CLU_103849_0_1_1; -.
DR InParanoid; Q5TJE9; -.
DR OMA; IRAYRGI; -.
DR OrthoDB; 1343043at2759; -.
DR TreeFam; TF317649; -.
DR Reactome; R-CFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CFA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-CFA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-CFA-72649; Translation initiation complex formation.
DR Reactome; R-CFA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CFA-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-CFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-CFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-CFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR EvolutionaryTrace; Q5TJE9; -.
DR Proteomes; UP000002254; Chromosome 12.
DR Bgee; ENSCAFG00000000950; Expressed in ovary and 48 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:AgBase.
DR GO; GO:0015935; C:small ribosomal subunit; ISS:AgBase.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 4.10.910.10; -; 1.
DR HAMAP; MF_01315; Ribosomal_S13_S18; 1.
DR InterPro; IPR027437; 30s_Rbsml_prot_S13_C.
DR InterPro; IPR001892; Ribosomal_S13.
DR InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR InterPro; IPR018269; Ribosomal_S13_CS.
DR Pfam; PF00416; Ribosomal_S13; 1.
DR PIRSF; PIRSF002134; Ribosomal_S13; 1.
DR SUPFAM; SSF46946; SSF46946; 1.
DR PROSITE; PS00646; RIBOSOMAL_S13_1; 1.
DR PROSITE; PS50159; RIBOSOMAL_S13_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CHAIN 2..152
FT /note="40S ribosomal protein S18"
FT /id="PRO_0000132211"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT MOD_RES 94
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT MOD_RES 106
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 91
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 94
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 106
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
SQ SEQUENCE 152 AA; 17719 MW; 4DAF0662C3F37F22 CRC64;
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK
