ID   B2_BBV                  Reviewed;         106 AA.
AC   P68830; P29100; Q89618; Q96632;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   07-OCT-2020, entry version 37.
DE   RecName: Full=Protein B2;
GN   Name=B2;
OS   Black beetle virus (BBV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae; Alphanodavirus.
OX   NCBI_TaxID=12285;
OH   NCBI_TaxID=295550; Heteronychus arator (African black beetle).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6495657; DOI=10.1016/0042-6822(84)90342-8;
RA   Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.;
RT   "Sequence of the black beetle virus subgenomic RNA and its location in the
RT   viral genome.";
RL   Virology 139:199-203(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3839022; DOI=10.1016/0022-2836(85)90337-7;
RA   Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.;
RT   "Structure of the black beetle virus genome and its functional
RT   implications.";
RL   J. Mol. Biol. 182:183-189(1985).
CC   -!- FUNCTION: Binds double-strand RNA (dsRNA) with high affinity.
CC       Suppresses the host RNA silencing-based antiviral response (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels early in the viral
CC       replication cycle.
CC   -!- DOMAIN: The dsRNA-binding region is required for suppression of RNA
CC       silencing. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Encoded on a subgenomic RNA (RNA3) synthesized during
CC       replication and which is co-terminal with RNA1.
CC   -!- SIMILARITY: Belongs to the nodaviridae B2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M33065; AAA42746.1; -; Genomic_RNA.
DR   EMBL; X02396; CAA26240.1; -; Genomic_RNA.
DR   PIR; B23243; QQBBB2.
DR   RefSeq; YP_227598.1; NC_001411.2.
DR   SMR; P68830; -.
DR   GeneID; 956651; -.
DR   KEGG; vg:956651; -.
DR   Proteomes; UP000203003; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR024377; RNA-bd_B2.
DR   InterPro; IPR037209; RNA-bd_B2_sf.
DR   Pfam; PF11473; B2; 1.
DR   SUPFAM; SSF140506; SSF140506; 1.
PE   2: Evidence at transcript level;
KW   RNA-binding; Suppressor of RNA silencing.
FT   CHAIN           1..106
FT                   /note="Protein B2"
FT                   /id="PRO_0000222453"
FT   REGION          1..73
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        14
FT                   /note="R -> P (in Ref. 1; AAA42746)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   106 AA;  11646 MW;  FA79D28C4AB99CA9 CRC64;
     MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL TVSRMVTSLL
     EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD PPPAKL